Impact of influenza syndrome and flu vaccine on survival of cancer patients during immunotherapy in the INVIDIa study

Melissa Bersanelli, Sebastiano Buti, Giuseppe Luigi Banna, Ugo De Giorgi, Alessio Cortellini, Sara Elena Rebuzzi, Marcello Tiseo, Giuseppe Fornarini, Francesca Mazzoni, Stefano Panni, Michele De Tursi, Pietro Di Marino, Sabrina Rossetti, Ernesto Rossi, Silverio Tomao, Emmanuele De Luca, Mariella Sorarù, Claudia Mucciarini, Francesco Atzori, Leonardo La TorreMaria Giuseppa Vitale, Valentino Martelli, Pierangela Sepe, Veronica Mollica, Vanja Vaccaro, Giovanni Schinzari, Corrado Ficorella, Francesco Massari, Antonio Maestri, Roberto Sabbatini, Teodoro Sava, Massimo Di Maio, Elena Verzoni, Giuseppe Procopio, Diana Giannarelli

Research output: Contribution to journalArticle

Abstract

Aim: INVIDIa was a retrospective, multicenter study, exploring the clinical efficacy of influenza vaccine in 300 cancer patients undergoing immunotherapy. Overall survival (OS) was immature at the initial report. Methods: We reported the final OS analysis from the original study population and within subgroups. Results: Both at the univariate and multivariate analysis, the occurrence of influenza syndrome (IS) was significantly related to better OS in the overall population (OR: 0.53 [95% CI: 0.32-0.88]; p = 0.01). In the lung cancer subgroup, receiving flu vaccine and/or developing IS was related to better OS (p = 0.04). Within elderly patients, the flu vaccine was the main variable for the relative OS advantage (p = 0.05). Conclusion: Receiving the flu vaccine and/or developing IS was related to better OS within the INVIDIa population.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalImmunotherapy
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • flu vaccine
  • immune checkpoint inhibitors
  • immunotherapy
  • influenza syndrome
  • influenza vaccination
  • overall survival

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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  • Cite this

    Bersanelli, M., Buti, S., Banna, G. L., Giorgi, U. D., Cortellini, A., Rebuzzi, S. E., Tiseo, M., Fornarini, G., Mazzoni, F., Panni, S., Tursi, M. D., Marino, P. D., Rossetti, S., Rossi, E., Tomao, S., Luca, E. D., Sorarù, M., Mucciarini, C., Atzori, F., ... Giannarelli, D. (2020). Impact of influenza syndrome and flu vaccine on survival of cancer patients during immunotherapy in the INVIDIa study. Immunotherapy, 12(2), 151-159. https://doi.org/10.2217/imt-2019-0180