Abstract
Objectives: To report the results of neoadjuvant chemotherapy (NACT) and the impact of interval debulking surgery (IDS) on clinical outcomes of patients considered unresectable at primary surgery. Methods: Retrospective analysis was carried out on 73 consecutive stage IIIc ovarian cancer patients treated with platinum-based NACT followed by IDS. Their clinical outcomes were compared with those of 111 consecutive stage IIIc ovarian cancer patients treated with primary cytoreduction followed by platinum-based adjuvant chemotherapy. Results: Patients who underwent successful IDS had a more favorable prognosis than those who did not in terms of time to progression (TTP) (p = 0.00001), and overall survival (OS) (p = 0.0001). On the other hand, in the group of patients that underwent successful IDS, no differences in survival outcomes were observed between patients with no residual disease and patients with macroscopic residual disease
Original language | English |
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Pages (from-to) | 316-322 |
Number of pages | 7 |
Journal | Oncology |
Volume | 65 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Advanced stage
- Interval debulking surgery
- Neoadjuvant chemotherapy
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology