Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

Daniele Porru, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos, Barbara Gardella, Maria Diletta Daccò, Rossella Elena Nappi, Massimo Allegri, Carmine Tinelli, Carlo Maria Bianchi, Arsenio Spinillo, Bruno Rovereto

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p

Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalInternational Urogynecology Journal and Pelvic Floor Dysfunction
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Bladder pain syndrome
  • Chondroitin
  • Hyaluronic acid
  • Interstitial cystitis

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology

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