Abstract
Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p
| Original language | English |
|---|---|
| Pages (from-to) | 1193-1199 |
| Number of pages | 7 |
| Journal | International Urogynecology Journal and Pelvic Floor Dysfunction |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2012 |
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Keywords
- Bladder pain syndrome
- Chondroitin
- Hyaluronic acid
- Interstitial cystitis
ASJC Scopus subject areas
- Urology
- Obstetrics and Gynaecology
Cite this
Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. / Porru, Daniele; Leva, Fabio; Parmigiani, Alberto; Barletta, Davide; Choussos, Dimitrios; Gardella, Barbara; Daccò, Maria Diletta; Nappi, Rossella Elena; Allegri, Massimo; Tinelli, Carmine; Bianchi, Carlo Maria; Spinillo, Arsenio; Rovereto, Bruno.
In: International Urogynecology Journal and Pelvic Floor Dysfunction, Vol. 23, No. 9, 09.2012, p. 1193-1199.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis
AU - Porru, Daniele
AU - Leva, Fabio
AU - Parmigiani, Alberto
AU - Barletta, Davide
AU - Choussos, Dimitrios
AU - Gardella, Barbara
AU - Daccò, Maria Diletta
AU - Nappi, Rossella Elena
AU - Allegri, Massimo
AU - Tinelli, Carmine
AU - Bianchi, Carlo Maria
AU - Spinillo, Arsenio
AU - Rovereto, Bruno
PY - 2012/9
Y1 - 2012/9
N2 - Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p
AB - Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p
KW - Bladder pain syndrome
KW - Chondroitin
KW - Hyaluronic acid
KW - Interstitial cystitis
UR - http://www.scopus.com/inward/record.url?scp=84868378950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868378950&partnerID=8YFLogxK
U2 - 10.1007/s00192-011-1546-5
DO - 10.1007/s00192-011-1546-5
M3 - Article
C2 - 21904840
AN - SCOPUS:84868378950
VL - 23
SP - 1193
EP - 1199
JO - International Urogynecology Journal and Pelvic Floor Dysfunction
JF - International Urogynecology Journal and Pelvic Floor Dysfunction
SN - 0937-3462
IS - 9
ER -