Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

Daniele Porru, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos, Barbara Gardella, Maria Diletta Daccò, Rossella Elena Nappi, Massimo Allegri, Carmine Tinelli, Carlo Maria Bianchi, Arsenio Spinillo, Bruno Rovereto

Research output: Contribution to journalArticle

Abstract

Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p

Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalInternational Urogynecology Journal and Pelvic Floor Dysfunction
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 2012

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Interstitial Cystitis
Chondroitin Sulfates
Hyaluronic Acid
Intravesical Administration
Urinary Bladder
Pain
Glycosaminoglycans
Sodium Chloride
Regeneration
Sodium
Urine

Keywords

  • Bladder pain syndrome
  • Chondroitin
  • Hyaluronic acid
  • Interstitial cystitis

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology

Cite this

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title = "Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis",
abstract = "Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6{\%} and CS 2.0{\%} in 0.9{\%} saline solution (IALURIL {\circledR}, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p",
keywords = "Bladder pain syndrome, Chondroitin, Hyaluronic acid, Interstitial cystitis",
author = "Daniele Porru and Fabio Leva and Alberto Parmigiani and Davide Barletta and Dimitrios Choussos and Barbara Gardella and Dacc{\`o}, {Maria Diletta} and Nappi, {Rossella Elena} and Massimo Allegri and Carmine Tinelli and Bianchi, {Carlo Maria} and Arsenio Spinillo and Bruno Rovereto",
year = "2012",
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AU - Porru, Daniele

AU - Leva, Fabio

AU - Parmigiani, Alberto

AU - Barletta, Davide

AU - Choussos, Dimitrios

AU - Gardella, Barbara

AU - Daccò, Maria Diletta

AU - Nappi, Rossella Elena

AU - Allegri, Massimo

AU - Tinelli, Carmine

AU - Bianchi, Carlo Maria

AU - Spinillo, Arsenio

AU - Rovereto, Bruno

PY - 2012/9

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N2 - Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p

AB - Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p

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