Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

Daniele Porru; Fabio Leva; Alberto Parmigiani; Davide Barletta; Dimitrios Choussos; Barbara Gardella; Maria Diletta Daccò; Rossella Elena Nappi; Massimo Allegri; Carmine Tinelli; Carlo Maria Bianchi; Arsenio Spinillo; Bruno Rovereto

doi:10.1007/s00192-011-1546-5

Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

Daniele Porru, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos, Barbara Gardella, Maria Diletta Daccò, Rossella Elena Nappi, Massimo Allegri, Carmine Tinelli, Carlo Maria Bianchi, Arsenio Spinillo, Bruno Rovereto

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL ^®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p

Original language	English
Pages (from-to)	1193-1199
Number of pages	7
Journal	International Urogynecology Journal and Pelvic Floor Dysfunction
Volume	23
Issue number	9
DOIs	https://doi.org/10.1007/s00192-011-1546-5
Publication status	Published - Sep 2012

Keywords

Bladder pain syndrome
Chondroitin
Hyaluronic acid
Interstitial cystitis

ASJC Scopus subject areas

Urology
Obstetrics and Gynaecology

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10.1007/s00192-011-1546-5

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Porru, D., Leva, F., Parmigiani, A., Barletta, D., Choussos, D., Gardella, B., Daccò, M. D., Nappi, R. E., Allegri, M., Tinelli, C., Bianchi, C. M., Spinillo, A., & Rovereto, B. (2012). Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. International Urogynecology Journal and Pelvic Floor Dysfunction, 23(9), 1193-1199. https://doi.org/10.1007/s00192-011-1546-5

Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. / Porru, Daniele; Leva, Fabio; Parmigiani, Alberto; Barletta, Davide; Choussos, Dimitrios; Gardella, Barbara; Daccò, Maria Diletta; Nappi, Rossella Elena; Allegri, Massimo; Tinelli, Carmine ; Bianchi, Carlo Maria ; Spinillo, Arsenio; Rovereto, Bruno.

In: International Urogynecology Journal and Pelvic Floor Dysfunction, Vol. 23, No. 9, 09.2012, p. 1193-1199.

Research output: Contribution to journal › Article › peer-review

Porru, D, Leva, F, Parmigiani, A, Barletta, D, Choussos, D, Gardella, B, Daccò, MD, Nappi, RE, Allegri, M, Tinelli, C , Bianchi, CM , Spinillo, A & Rovereto, B 2012, 'Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis', International Urogynecology Journal and Pelvic Floor Dysfunction, vol. 23, no. 9, pp. 1193-1199. https://doi.org/10.1007/s00192-011-1546-5

Porru, Daniele ; Leva, Fabio ; Parmigiani, Alberto ; Barletta, Davide ; Choussos, Dimitrios ; Gardella, Barbara ; Daccò, Maria Diletta ; Nappi, Rossella Elena ; Allegri, Massimo ; Tinelli, Carmine ; Bianchi, Carlo Maria ; Spinillo, Arsenio ; Rovereto, Bruno. / Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. In: International Urogynecology Journal and Pelvic Floor Dysfunction. 2012 ; Vol. 23, No. 9. pp. 1193-1199.

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abstract = "Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL {\textregistered}, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 (p=0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p=0.0001). The average urine volume increased from 129.7 to 162 ml (p",

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AU - Choussos, Dimitrios

AU - Gardella, Barbara

AU - Daccò, Maria Diletta

AU - Nappi, Rossella Elena

AU - Allegri, Massimo

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Impact of Intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

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Keywords

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