Impact of ischemia/reperfusion on transplanted livers procured from elderly cadaveric donors

Gregorio Santori, E. Andorno, N. Morelli, A. Gianelli Castiglione, M. Casaccia, L. Saltalamacchia, F. Panaro, D. Cottalasso, U. Valente

Research output: Contribution to journalArticle

Abstract

The increasing number of clinical indications for liver transplantation has forced physicians to use livers procured from elderly cadaveric donors to expand the graft pool However, the degree of ischemia/reperfusion damage in elderly livers remains poorly investigated. In this study, the outcomes of livers procured from a group (I) of young donors (n = 12; 38 ± 12 years; range: 21-58) were compared with a group (II) from elderly donors (n = 7; 68 ± 7 years; range: 62-84) for changes in reduced glutathione, the main hepatic free radical scavenger. Reduced and oxidized glutathione were assayed by high performance liquid chromatography in liver biopsies performed just before cold ischemia and during early reperfusion. A significant decrease in reduced glutathione was observed at the time of reperfusion in both groups I (P = .0195) and II (P = .002). Before cold ischemia and during early reperfusion, no differences between young versus elderly donors were noted in the oxidized/reduced glutathione ratio, in conventional graft function markers or in liver-related hemostatic parameters. Comparable glutathione contents were measured at the time of early reperfusion in livers obtained from young and elderly cadaveric donors, suggesting that livers procured from elderly donors might be adequately protected against ischemia/reperfusion damage.

Original languageEnglish
Pages (from-to)2909-2913
Number of pages5
JournalTransplantation Proceedings
Volume36
Issue number10
DOIs
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Santori, G., Andorno, E., Morelli, N., Gianelli Castiglione, A., Casaccia, M., Saltalamacchia, L., Panaro, F., Cottalasso, D., & Valente, U. (2004). Impact of ischemia/reperfusion on transplanted livers procured from elderly cadaveric donors. Transplantation Proceedings, 36(10), 2909-2913. https://doi.org/10.1016/j.transproceed.2004.10.069