Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: Results from an inter-cohort analysis

Massimo Puoti, Alessandro Cozzi-Lepri, Claudio Arici, Nina Friis Moller, Jens D. Lundgren, Bruno Ledergerber, Martin Rickenbach, Ignacio Suarez-Lozano, Myriam Garrido, Francois Dabis, Maria Winnock, Laura Milazzo, Anne Gervais, Francois Raffi, John Gill, Juergen Rockstroh, Nazifa Qurishi, Cristina Mussini, Antonella Castagna, Andrea De LucaAntonella D Arminio Monforte

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The impact of lamivudine (3TC) as part of combination antiretroviral therapy (cART) on the risk of liver-related death (LRD) in HIV/hepatitis B virus (HBV)-coinfected patients has not been extensively studied. Methods: We performed an analysis involving HIV/HBV-coinfected patients in 13 cohorts who initiated cART. The end-point was LRD - that is, death with concomitant decompensated liver disease (DLD) or hepatocellular carcinoma - as the main cause. Incidence rates of LRD after initiation of cART were expressed as number of events per 100 person-years of follow-up (PYFU). A Poisson regression model adjusted for cohort, gender, mode of HIV transmission, CD4 + T-cell count at cART initiation, liver disease pre-cART, duration of 3TC before cART, and hepatitis C virus was used to assess the association between use of 3TC and risk of LRD. Results: We analysed 2,041 patients. Follow-up after starting cART was 7.648 PYFU (5,569 spent on 3TC-containing regimens) with a median per person of 48 months (range: 2-91). Of the total, 217 subjects died; 57 deaths were liver-related resulting in a rate of 7.5 per 1,000 PYFU [95% confidence intervals (CI): 5.6-9.7]. The relative risk of LRD per extra year of 3TC use was 0.73 (95% CI: 0.59-0.90, P=0.004). Conclusion: The use of 3TC was associated with a reduced risk of LRD over 4 years of follow-up. This study supports the current view that the use of 3TC as part of cART should be considered in patients who are tested positive for HBsAg.

Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalAntiviral Therapy
Volume11
Issue number5
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: Results from an inter-cohort analysis'. Together they form a unique fingerprint.

Cite this