Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database

Giorgio Sesti, Francesco Andreozzi, Riccardo C. Bonadonna, Giancarlo De Mattia, Frida Leonetti, Livio Luzi, Maria Adelaide Marini, Andrea Natali, Roberto Vettor, Enzo Bonora

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects. Research design and methods: This study included 930 non-diabetic Italian Caucasians from the GISIR database in which subjects underwent a hyperinsulinaemic-euglycaemic clamp performed with a standard technique. Low insulin sensitivity was defined as being in the lower quartile of glucose metabolized during the last hour of the clamp (M). Subjects were stratified in the following groups: normal fasting glucose (NFG) (1997 IFG110 (110-125 mg/ dL), and ADA2003 IFG (100-125 mg/dL). Results: The sensitivity of identifying subjects with low insulin sensitivity increased adopting the ADA2003 criterion. After Bonferroni correction for multiple comparisons, both IFG100 and ADA1997 IFG110 showed significantly higher body mass index (BMI), waist, systolic blood pressure (SBP) and diastolic blood pressure (DBP), triglyceride, fasting plasma insulin (FPI) and fasting plasma glucose (FPG), and lower insulin sensitivity as compared with NFG. As compared with IFG100, ADA1997 IFG110 showed significantly higher BMI, waist, SBP, FPI, FPG, and lower insulin sensitivity. ADA2003 IFG group showed significantly higher BMI, waist, SBP and DBP, triglyceride, cholesterol, FPI, and FPG, but lower HDL levels and insulin sensitivity compared with NFG subjects. Conclusions: Although neither the ADA2003 nor the ADA1997 definition of IFG appears to be particularly efficacious for the identification of subjects' low insulin sensitivity, lowering the criterion to the ADA2003 glucose threshold increased the sensitivity without affecting the specificity. ADA2003 IFG showed a worse cardiovascular risk profile compared with NFG.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Insulin Resistance
Fasting
Databases
Insulin
Glucose
Blood Pressure
Blood pressure
Plasmas
Body Mass Index
Clamping devices
Triglycerides
Glucose Clamp Technique
Research Design
Cholesterol

Keywords

  • Cardiovascular risk factors
  • Impaired fasting glucose
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database. / Sesti, Giorgio; Andreozzi, Francesco; Bonadonna, Riccardo C.; De Mattia, Giancarlo; Leonetti, Frida; Luzi, Livio; Marini, Maria Adelaide; Natali, Andrea; Vettor, Roberto; Bonora, Enzo.

In: Diabetes/Metabolism Research and Reviews, Vol. 24, No. 2, 02.2008, p. 130-136.

Research output: Contribution to journalArticle

Sesti, G, Andreozzi, F, Bonadonna, RC, De Mattia, G, Leonetti, F, Luzi, L, Marini, MA, Natali, A, Vettor, R & Bonora, E 2008, 'Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database', Diabetes/Metabolism Research and Reviews, vol. 24, no. 2, pp. 130-136. https://doi.org/10.1002/dmrr.775
Sesti, Giorgio ; Andreozzi, Francesco ; Bonadonna, Riccardo C. ; De Mattia, Giancarlo ; Leonetti, Frida ; Luzi, Livio ; Marini, Maria Adelaide ; Natali, Andrea ; Vettor, Roberto ; Bonora, Enzo. / Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database. In: Diabetes/Metabolism Research and Reviews. 2008 ; Vol. 24, No. 2. pp. 130-136.
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AU - De Mattia, Giancarlo

AU - Leonetti, Frida

AU - Luzi, Livio

AU - Marini, Maria Adelaide

AU - Natali, Andrea

AU - Vettor, Roberto

AU - Bonora, Enzo

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