Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy

Marco Roscigno; Shahrokh F. Shariat; Vitaly Margulis; Pierre Karakiewicz; Mesut Remzi; Eiji Kikuchi; Cord Langner; Yair Lotan; Alon Weizer; Karim Bensalah; Jay D. Raman; Christian Bolenz; Charles C. Guo; Christopher G. Wood; Richard Zigeuner; Jeffrey Wheat; Wareef Kabbani; Theresa M. Koppie; Casey K. Ng; Nazareno Suardi; Roberto Bertini; Mario I. Fernández; Shuji Mikami; Masaru Isida; Maurice Stephan Michel; Francesco Montorsi

doi:10.1016/j.juro.2009.02.021

Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy

Marco Roscigno, Shahrokh F. Shariat, Vitaly Margulis, Pierre Karakiewicz, Mesut Remzi, Eiji Kikuchi, Cord Langner, Yair Lotan, Alon Weizer, Karim Bensalah, Jay D. Raman, Christian Bolenz, Charles C. Guo, Christopher G. Wood, Richard Zigeuner, Jeffrey Wheat, Wareef Kabbani, Theresa M. Koppie, Casey K. Ng, Nazareno SuardiRoberto Bertini, Mario I. Fernández, Shuji Mikami, Masaru Isida, Maurice Stephan Michel, Francesco Montorsi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: We examined the impact of lymphadenectomy on the clinical outcomes of patients with upper tract urothelial cancer treated with radical nephroureterectomy. Materials and Methods: Data were collected on 1,130 consecutive patients with pT1-4 upper tract urothelial cancer treated with radical nephroureterectomy at 13 centers worldwide. Patients were grouped according to nodal status (pN0 vs pNx vs pN+). The choice to perform lymphadenectomy was determined by the treating surgeon. All pathology slides were reevaluated by dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured the association of nodal status (pN0 vs pNx vs pN+) with cancer specific survival. Results: Overall 412 patients (36.5%) had pN0 disease, 578 had pNx disease (51.1%) and 140 had pN+ disease (12.4%). The 5-year cancer specific survival estimate was lower in patients with pN+ compared to those with pNx disease (35% vs 69%, p

Original language	English
Pages (from-to)	2482-2489
Number of pages	8
Journal	Journal of Urology
Volume	181
Issue number	6
DOIs	https://doi.org/10.1016/j.juro.2009.02.021
Publication status	Published - Jun 2009

Keywords

carcinoma
lymph node excision
prognosis
survival
transitional cell
urologic neoplasms

ASJC Scopus subject areas

Urology

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Roscigno, M., Shariat, S. F., Margulis, V., Karakiewicz, P., Remzi, M., Kikuchi, E., Langner, C., Lotan, Y., Weizer, A., Bensalah, K., Raman, J. D., Bolenz, C., Guo, C. C., Wood, C. G., Zigeuner, R., Wheat, J., Kabbani, W., Koppie, T. M., Ng, C. K., ... Montorsi, F. (2009). Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy. Journal of Urology, 181(6), 2482-2489. https://doi.org/10.1016/j.juro.2009.02.021

Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy. / Roscigno, Marco; Shariat, Shahrokh F.; Margulis, Vitaly; Karakiewicz, Pierre; Remzi, Mesut; Kikuchi, Eiji; Langner, Cord; Lotan, Yair; Weizer, Alon; Bensalah, Karim; Raman, Jay D.; Bolenz, Christian; Guo, Charles C.; Wood, Christopher G.; Zigeuner, Richard; Wheat, Jeffrey; Kabbani, Wareef; Koppie, Theresa M.; Ng, Casey K.; Suardi, Nazareno ; Bertini, Roberto; Fernández, Mario I.; Mikami, Shuji; Isida, Masaru; Michel, Maurice Stephan; Montorsi, Francesco.

In: Journal of Urology, Vol. 181, No. 6, 06.2009, p. 2482-2489.

Research output: Contribution to journal › Article › peer-review

Roscigno, M, Shariat, SF, Margulis, V, Karakiewicz, P, Remzi, M, Kikuchi, E, Langner, C, Lotan, Y, Weizer, A, Bensalah, K, Raman, JD, Bolenz, C, Guo, CC, Wood, CG, Zigeuner, R, Wheat, J, Kabbani, W, Koppie, TM, Ng, CK, Suardi, N , Bertini, R, Fernández, MI, Mikami, S, Isida, M, Michel, MS & Montorsi, F 2009, 'Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy', Journal of Urology, vol. 181, no. 6, pp. 2482-2489. https://doi.org/10.1016/j.juro.2009.02.021

Roscigno, Marco ; Shariat, Shahrokh F. ; Margulis, Vitaly ; Karakiewicz, Pierre ; Remzi, Mesut ; Kikuchi, Eiji ; Langner, Cord ; Lotan, Yair ; Weizer, Alon ; Bensalah, Karim ; Raman, Jay D. ; Bolenz, Christian ; Guo, Charles C. ; Wood, Christopher G. ; Zigeuner, Richard ; Wheat, Jeffrey ; Kabbani, Wareef ; Koppie, Theresa M. ; Ng, Casey K. ; Suardi, Nazareno ; Bertini, Roberto ; Fernández, Mario I. ; Mikami, Shuji ; Isida, Masaru ; Michel, Maurice Stephan ; Montorsi, Francesco. / Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy. In: Journal of Urology. 2009 ; Vol. 181, No. 6. pp. 2482-2489.

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abstract = "Purpose: We examined the impact of lymphadenectomy on the clinical outcomes of patients with upper tract urothelial cancer treated with radical nephroureterectomy. Materials and Methods: Data were collected on 1,130 consecutive patients with pT1-4 upper tract urothelial cancer treated with radical nephroureterectomy at 13 centers worldwide. Patients were grouped according to nodal status (pN0 vs pNx vs pN+). The choice to perform lymphadenectomy was determined by the treating surgeon. All pathology slides were reevaluated by dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured the association of nodal status (pN0 vs pNx vs pN+) with cancer specific survival. Results: Overall 412 patients (36.5%) had pN0 disease, 578 had pNx disease (51.1%) and 140 had pN+ disease (12.4%). The 5-year cancer specific survival estimate was lower in patients with pN+ compared to those with pNx disease (35% vs 69%, p ",

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AU - Roscigno, Marco

AU - Shariat, Shahrokh F.

AU - Margulis, Vitaly

AU - Karakiewicz, Pierre

AU - Remzi, Mesut

AU - Kikuchi, Eiji

AU - Langner, Cord

AU - Lotan, Yair

AU - Weizer, Alon

AU - Bensalah, Karim

AU - Raman, Jay D.

AU - Bolenz, Christian

AU - Guo, Charles C.

AU - Wood, Christopher G.

AU - Zigeuner, Richard

AU - Wheat, Jeffrey

AU - Kabbani, Wareef

AU - Koppie, Theresa M.

AU - Ng, Casey K.

AU - Suardi, Nazareno

AU - Bertini, Roberto

AU - Fernández, Mario I.

AU - Mikami, Shuji

AU - Isida, Masaru

AU - Michel, Maurice Stephan

AU - Montorsi, Francesco

PY - 2009/6

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N2 - Purpose: We examined the impact of lymphadenectomy on the clinical outcomes of patients with upper tract urothelial cancer treated with radical nephroureterectomy. Materials and Methods: Data were collected on 1,130 consecutive patients with pT1-4 upper tract urothelial cancer treated with radical nephroureterectomy at 13 centers worldwide. Patients were grouped according to nodal status (pN0 vs pNx vs pN+). The choice to perform lymphadenectomy was determined by the treating surgeon. All pathology slides were reevaluated by dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured the association of nodal status (pN0 vs pNx vs pN+) with cancer specific survival. Results: Overall 412 patients (36.5%) had pN0 disease, 578 had pNx disease (51.1%) and 140 had pN+ disease (12.4%). The 5-year cancer specific survival estimate was lower in patients with pN+ compared to those with pNx disease (35% vs 69%, p

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