Abstract
Purpose: We examined the impact of lymphadenectomy on the clinical outcomes of patients with upper tract urothelial cancer treated with radical nephroureterectomy. Materials and Methods: Data were collected on 1,130 consecutive patients with pT1-4 upper tract urothelial cancer treated with radical nephroureterectomy at 13 centers worldwide. Patients were grouped according to nodal status (pN0 vs pNx vs pN+). The choice to perform lymphadenectomy was determined by the treating surgeon. All pathology slides were reevaluated by dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured the association of nodal status (pN0 vs pNx vs pN+) with cancer specific survival. Results: Overall 412 patients (36.5%) had pN0 disease, 578 had pNx disease (51.1%) and 140 had pN+ disease (12.4%). The 5-year cancer specific survival estimate was lower in patients with pN+ compared to those with pNx disease (35% vs 69%, p
Original language | English |
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Pages (from-to) | 2482-2489 |
Number of pages | 8 |
Journal | Journal of Urology |
Volume | 181 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2009 |
Keywords
- carcinoma
- lymph node excision
- prognosis
- survival
- transitional cell
- urologic neoplasms
ASJC Scopus subject areas
- Urology