Impact of Lymph Node Dissection on Cancer Specific Survival in Patients With Upper Tract Urothelial Carcinoma Treated With Radical Nephroureterectomy

Marco Roscigno, Shahrokh F. Shariat, Vitaly Margulis, Pierre Karakiewicz, Mesut Remzi, Eiji Kikuchi, Cord Langner, Yair Lotan, Alon Weizer, Karim Bensalah, Jay D. Raman, Christian Bolenz, Charles C. Guo, Christopher G. Wood, Richard Zigeuner, Jeffrey Wheat, Wareef Kabbani, Theresa M. Koppie, Casey K. Ng, Nazareno SuardiRoberto Bertini, Mario I. Fernández, Shuji Mikami, Masaru Isida, Maurice Stephan Michel, Francesco Montorsi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We examined the impact of lymphadenectomy on the clinical outcomes of patients with upper tract urothelial cancer treated with radical nephroureterectomy. Materials and Methods: Data were collected on 1,130 consecutive patients with pT1-4 upper tract urothelial cancer treated with radical nephroureterectomy at 13 centers worldwide. Patients were grouped according to nodal status (pN0 vs pNx vs pN+). The choice to perform lymphadenectomy was determined by the treating surgeon. All pathology slides were reevaluated by dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured the association of nodal status (pN0 vs pNx vs pN+) with cancer specific survival. Results: Overall 412 patients (36.5%) had pN0 disease, 578 had pNx disease (51.1%) and 140 had pN+ disease (12.4%). The 5-year cancer specific survival estimate was lower in patients with pN+ compared to those with pNx disease (35% vs 69%, p

Original languageEnglish
Pages (from-to)2482-2489
Number of pages8
JournalJournal of Urology
Volume181
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • carcinoma
  • lymph node excision
  • prognosis
  • survival
  • transitional cell
  • urologic neoplasms

ASJC Scopus subject areas

  • Urology

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