Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction

A post-hoc analysis of a multicenter randomized controlled trial

Michael Osthoff, Vanja Piezzi, Theresia Klima, Andreas Christ, Ivana Marana, Sabine Hartwiger, Tobias Breidthardt, Giancarlo Marenzi, Marten Trendelenburg, Christian Mueller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MBL deficiency with radiocontrast-induced renal dysfunction in a large prospective cohort. Methods. 246 patients with advanced non-dialysis-dependent renal dysfunction who underwent radiographic contrast procedures were included in the study. Baseline serum MBL levels were analyzed according to the occurrence of a creatinine-based (increase of 0.5mg/dL or 25% within 48hours) or cystatin C-based (increase of 10% within 24hours) CIN. Results: The incidence of creatinine-based and cystatin C-based CIN was 6.5% and 24%, respectively. MBL levels were not associated with the occurrence of creatinine-based CIN. However, patients that experienced a cystatin C increase of 10% showed significantly higher MBL levels than patients with a rise of

Original languageEnglish
Article number99
JournalBMC Nephrology
Volume13
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Mannose-Binding Lectin
Cystatin C
Randomized Controlled Trials
Kidney
Creatinine
Reperfusion Injury
Ischemia
Mannose-Binding Protein Deficiency
Incidence
Serum

Keywords

  • Acute kidney injury
  • Complement
  • Contrast-induced nephropathy
  • Ischemia/reperfusion injury
  • Mannose-binding lectin

ASJC Scopus subject areas

  • Nephrology

Cite this

Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction : A post-hoc analysis of a multicenter randomized controlled trial. / Osthoff, Michael; Piezzi, Vanja; Klima, Theresia; Christ, Andreas; Marana, Ivana; Hartwiger, Sabine; Breidthardt, Tobias; Marenzi, Giancarlo; Trendelenburg, Marten; Mueller, Christian.

In: BMC Nephrology, Vol. 13, No. 1, 99, 2012.

Research output: Contribution to journalArticle

Osthoff, Michael ; Piezzi, Vanja ; Klima, Theresia ; Christ, Andreas ; Marana, Ivana ; Hartwiger, Sabine ; Breidthardt, Tobias ; Marenzi, Giancarlo ; Trendelenburg, Marten ; Mueller, Christian. / Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction : A post-hoc analysis of a multicenter randomized controlled trial. In: BMC Nephrology. 2012 ; Vol. 13, No. 1.
@article{9ce649c8c6ef46fdbd8ec9a6496f1b93,
title = "Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: A post-hoc analysis of a multicenter randomized controlled trial",
abstract = "Background: Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MBL deficiency with radiocontrast-induced renal dysfunction in a large prospective cohort. Methods. 246 patients with advanced non-dialysis-dependent renal dysfunction who underwent radiographic contrast procedures were included in the study. Baseline serum MBL levels were analyzed according to the occurrence of a creatinine-based (increase of 0.5mg/dL or 25{\%} within 48hours) or cystatin C-based (increase of 10{\%} within 24hours) CIN. Results: The incidence of creatinine-based and cystatin C-based CIN was 6.5{\%} and 24{\%}, respectively. MBL levels were not associated with the occurrence of creatinine-based CIN. However, patients that experienced a cystatin C increase of 10{\%} showed significantly higher MBL levels than patients with a rise of",
keywords = "Acute kidney injury, Complement, Contrast-induced nephropathy, Ischemia/reperfusion injury, Mannose-binding lectin",
author = "Michael Osthoff and Vanja Piezzi and Theresia Klima and Andreas Christ and Ivana Marana and Sabine Hartwiger and Tobias Breidthardt and Giancarlo Marenzi and Marten Trendelenburg and Christian Mueller",
year = "2012",
doi = "10.1186/1471-2369-13-99",
language = "English",
volume = "13",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BMC",
number = "1",

}

TY - JOUR

T1 - Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction

T2 - A post-hoc analysis of a multicenter randomized controlled trial

AU - Osthoff, Michael

AU - Piezzi, Vanja

AU - Klima, Theresia

AU - Christ, Andreas

AU - Marana, Ivana

AU - Hartwiger, Sabine

AU - Breidthardt, Tobias

AU - Marenzi, Giancarlo

AU - Trendelenburg, Marten

AU - Mueller, Christian

PY - 2012

Y1 - 2012

N2 - Background: Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MBL deficiency with radiocontrast-induced renal dysfunction in a large prospective cohort. Methods. 246 patients with advanced non-dialysis-dependent renal dysfunction who underwent radiographic contrast procedures were included in the study. Baseline serum MBL levels were analyzed according to the occurrence of a creatinine-based (increase of 0.5mg/dL or 25% within 48hours) or cystatin C-based (increase of 10% within 24hours) CIN. Results: The incidence of creatinine-based and cystatin C-based CIN was 6.5% and 24%, respectively. MBL levels were not associated with the occurrence of creatinine-based CIN. However, patients that experienced a cystatin C increase of 10% showed significantly higher MBL levels than patients with a rise of

AB - Background: Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MBL deficiency with radiocontrast-induced renal dysfunction in a large prospective cohort. Methods. 246 patients with advanced non-dialysis-dependent renal dysfunction who underwent radiographic contrast procedures were included in the study. Baseline serum MBL levels were analyzed according to the occurrence of a creatinine-based (increase of 0.5mg/dL or 25% within 48hours) or cystatin C-based (increase of 10% within 24hours) CIN. Results: The incidence of creatinine-based and cystatin C-based CIN was 6.5% and 24%, respectively. MBL levels were not associated with the occurrence of creatinine-based CIN. However, patients that experienced a cystatin C increase of 10% showed significantly higher MBL levels than patients with a rise of

KW - Acute kidney injury

KW - Complement

KW - Contrast-induced nephropathy

KW - Ischemia/reperfusion injury

KW - Mannose-binding lectin

UR - http://www.scopus.com/inward/record.url?scp=84865589535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865589535&partnerID=8YFLogxK

U2 - 10.1186/1471-2369-13-99

DO - 10.1186/1471-2369-13-99

M3 - Article

VL - 13

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 99

ER -