Impact of Mediterranean diet on metabolic syndrome, cancer and longevity

Nicola D. Di Daniele, Annalisa Noce, Maria Francesca Vidiri, Eleonora Moriconi, Giulia Marrone, Margherita Annicchiarico-Petruzzelli, Gabriele D'Urso, Manfredi Tesauro, Valentina Rovella, Antonino D. De Lorenzo

Research output: Contribution to journalReview article

Abstract

Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome, preventing adiposopathy or "sick fat" formation. The Mediterranean Diet exerts protective effects in elderly subjects with and without baseline of chronic diseases. Recent studies have demonstrated a relationship between cancer and obesity. In the US, diet represents amount 30-35% of death causes related to cancer. Currently, the cancer is the second cause of death after cardiovascular diseases worldwide. Furthermore, populations living in the Mediterranean area have a decreased incidence of cancer compared with populations living in Northern Europe or the US, likely due to healthier dietary habits. The bioactive food components have a potential preventive action on cancer. The aims of this review are to evaluate the impact of Mediterranean Diet on onset, progression and regression of metabolic syndrome, cancer and on longevity.

Original languageEnglish
Pages (from-to)8947-8979
Number of pages33
JournalOncotarget
Volume8
Issue number5
Publication statusPublished - Jan 1 2017

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Keywords

  • Antioxidant
  • Cancer
  • Mediterranean diet
  • Obesity
  • Public health

ASJC Scopus subject areas

  • Oncology

Cite this

Di Daniele, N. D., Noce, A., Vidiri, M. F., Moriconi, E., Marrone, G., Annicchiarico-Petruzzelli, M., D'Urso, G., Tesauro, M., Rovella, V., & De Lorenzo, A. D. (2017). Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget, 8(5), 8947-8979.