Impact of mesorectal status on local recurrence and survival in patients with rectal cancer

F. Bozzetti, L. Bertario

Research output: Contribution to journalArticle

Abstract

The main aim of this paper is to evaluate, by reviewing the most pertinent literature, both the prognostic impact of the mesorectum status in patients with cancer of the rectum and the rationale for mesorectal excision. Recent literature has been considered with special reference to the outcomes of the mesorectal surgical treatment on the relapse rate and survival. The infiltration of the mesorectum adversely affects the prognosis of the patient after a curative operation, whereas it is doubtful whether its excision per se is able to improve the prognosis. Therefore, involvement of the mesorectum may be considered to be an important indicator of already advanced and aggressive malignancy more than the true cause for the relapse. In fact, lately, some authors have pointed out that the extent of the mesorectal excision should be tailored to the specific case in order to achieve adequate and safe surgical margins and have enough prognostic information. Indiscriminate total mesorectal excision in all rectal tumours is not supported by data showing a prognostic improvement. Consequently, surgical management should be carefully planned considering the potential risks and the complications affecting this procedure.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalTechniques in Coloproctology
Volume4
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Rectal Neoplasms
Recurrence
Survival
Survival Rate
Neoplasms
Therapeutics
Margins of Excision

Keywords

  • Lateral margin
  • Mesorectal spread Circumferential margins
  • Mesorectum
  • Rectal cancer
  • Total mesorectal excision

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Impact of mesorectal status on local recurrence and survival in patients with rectal cancer. / Bozzetti, F.; Bertario, L.

In: Techniques in Coloproctology, Vol. 4, No. 1, 2000, p. 49-53.

Research output: Contribution to journalArticle

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