Abstract
Background Liver transplantation (OLT) can entail a high risk of blood loss requiring transfusions, which increase morbidity and mortality. In recent years many efforts have been spent to improve the surgical and anesthetic management to decrease transfusion rates during OLT. Preoperative predictors for transfusion in OLT, remain uncertain. Methods We retrospectively reviewed the 219 OLT performed from 2005 to 2011 focusing on blood product (BP) transfusions. Statistical analysis sought the impact of transfusions on OLT outcomes to identify possible independent predictors of higher BP requirements. Results The 1- and 3-year survival rates were 86.6% and 76.45% for patients and 81.0% and 71.8% for grafts respectively. The mean intra- and perioperative red blood cell (RBC) transfusion rates were 12.3 ± 11.7 U and 15.5 ± 13.0 U respectively. A statistical analysis demonstrated a significant influence of BP transfusion on post-OLT complications and survivals. Multivariate logistic regression analysis showed the Model for End-Stage Liver Disease (MELD) score to be the only independent predictor of perioperative RBC transfusions. Conclusions Our results confirmed the link between intra- and perioperative transfusions and outcome of OLT patients. MELD score resulted the only independent variable associated with increased perioperative RBC transfusions.
| Original language | English |
|---|---|
| Pages (from-to) | 2684-2688 |
| Number of pages | 5 |
| Journal | Transplantation Proceedings |
| Volume | 45 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Sep 2013 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Impact of model for end-stage liver disease score on transfusion rates in liver transplantation. / Varotti, G.; Santori, G.; Andorno, E.; Morelli, N.; Ertreo, M.; Strada, P.; Porcile, E.; Casaccia, M.; Centanaro, M.; Valente, U.
In: Transplantation Proceedings, Vol. 45, No. 7, 09.2013, p. 2684-2688.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of model for end-stage liver disease score on transfusion rates in liver transplantation
AU - Varotti, G.
AU - Santori, G.
AU - Andorno, E.
AU - Morelli, N.
AU - Ertreo, M.
AU - Strada, P.
AU - Porcile, E.
AU - Casaccia, M.
AU - Centanaro, M.
AU - Valente, U.
PY - 2013/9
Y1 - 2013/9
N2 - Background Liver transplantation (OLT) can entail a high risk of blood loss requiring transfusions, which increase morbidity and mortality. In recent years many efforts have been spent to improve the surgical and anesthetic management to decrease transfusion rates during OLT. Preoperative predictors for transfusion in OLT, remain uncertain. Methods We retrospectively reviewed the 219 OLT performed from 2005 to 2011 focusing on blood product (BP) transfusions. Statistical analysis sought the impact of transfusions on OLT outcomes to identify possible independent predictors of higher BP requirements. Results The 1- and 3-year survival rates were 86.6% and 76.45% for patients and 81.0% and 71.8% for grafts respectively. The mean intra- and perioperative red blood cell (RBC) transfusion rates were 12.3 ± 11.7 U and 15.5 ± 13.0 U respectively. A statistical analysis demonstrated a significant influence of BP transfusion on post-OLT complications and survivals. Multivariate logistic regression analysis showed the Model for End-Stage Liver Disease (MELD) score to be the only independent predictor of perioperative RBC transfusions. Conclusions Our results confirmed the link between intra- and perioperative transfusions and outcome of OLT patients. MELD score resulted the only independent variable associated with increased perioperative RBC transfusions.
AB - Background Liver transplantation (OLT) can entail a high risk of blood loss requiring transfusions, which increase morbidity and mortality. In recent years many efforts have been spent to improve the surgical and anesthetic management to decrease transfusion rates during OLT. Preoperative predictors for transfusion in OLT, remain uncertain. Methods We retrospectively reviewed the 219 OLT performed from 2005 to 2011 focusing on blood product (BP) transfusions. Statistical analysis sought the impact of transfusions on OLT outcomes to identify possible independent predictors of higher BP requirements. Results The 1- and 3-year survival rates were 86.6% and 76.45% for patients and 81.0% and 71.8% for grafts respectively. The mean intra- and perioperative red blood cell (RBC) transfusion rates were 12.3 ± 11.7 U and 15.5 ± 13.0 U respectively. A statistical analysis demonstrated a significant influence of BP transfusion on post-OLT complications and survivals. Multivariate logistic regression analysis showed the Model for End-Stage Liver Disease (MELD) score to be the only independent predictor of perioperative RBC transfusions. Conclusions Our results confirmed the link between intra- and perioperative transfusions and outcome of OLT patients. MELD score resulted the only independent variable associated with increased perioperative RBC transfusions.
UR - http://www.scopus.com/inward/record.url?scp=84884364361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884364361&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2013.07.006
DO - 10.1016/j.transproceed.2013.07.006
M3 - Article
C2 - 24034024
AN - SCOPUS:84884364361
VL - 45
SP - 2684
EP - 2688
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 7
ER -