Impact of neoadjuvant therapy followed by laparoscopic radical gastrectomy with D2 lymph node dissection in Western population: A multi-institutional propensity score-matched study

Umberto Bracale, Francesco Corcione, Giusto Pignata, Jacopo Andreuccetti, Pasquale Dolce, Luigi Boni, Elisa Cassinotti, Stefano Olmi, Matteo Uccelli, Monica Gualtierotti, Giovanni Ferrari, Paolo De Martini, Miloš Bjelović, Dragan Gunjić, Diego Cuccurullo, Antonio Sciuto, Felice Pirozzi, Roberto Peltrini

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: In the setting of a minimally invasive approach, we aimed to compare short and long-term postoperative outcomes of patients treated with neoadjuvant therapy (NAT) + surgery or upfront surgery in Western population. Methods: All consecutive patients from six Italian and one Serbian center with locally advanced gastric cancer who had undergone laparoscopic gastrectomy with D2 lymph node dissection were selected between 2005 and 2019. After propensity score-matching, postoperative morbidity and oncologic outcomes were investigated. Results: After matching, 97 patients were allocated in each cohort with a mean age of 69.4 and 70.5 years. The two groups showed no difference in operative details except for a higher conversion rate in the NAT group (p = 0.038). The overall postoperative complications rate significantly differed between NAT + surgery (38.1%) and US (21.6%) group (p = 0.019). NAT was found to be related to a higher risk of postoperative morbidity in patients older than 60 years old (p = 0.013) but not in patients younger (p = 0.620). Conversely, no difference in overall survival (p = 0.41) and disease-free-survival (p = 0.34) was found between groups. Conclusions: NAT appears to be related to a higher postoperative complication rate and equivalent oncological outcomes when compared with surgery alone. However, poor short-term outcomes are more evident in patients over 60 years old receiving NAT.

Original languageEnglish
JournalJournal of Surgical Oncology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • gastric cancer
  • laparoscopic gastrectomy
  • neoadjuvant therapy
  • oncological outcomes
  • postoparative complications

ASJC Scopus subject areas

  • Surgery
  • Oncology

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