Impact of obesity and hyperglycemia on placental mitochondria

C Mandò, GM Anelli, C Novielli, P Panina-Bordignon, M Massari, MI Mazzocco, Irene Cetin

Research output: Contribution to journalArticle

Abstract

A lipotoxic placental environment is recognized in maternal obesity, with increased inflammation and oxidative stress. These changes might alter mitochondrial function, with excessive production of reactive oxygen species, in a vicious cycle leading to placental dysfunction and impaired pregnancy outcomes. Here, we hypothesize that maternal pregestational body mass index (BMI) and glycemic levels can alter placental mitochondria. We measured mitochondrial DNA (mtDNA, real-time PCR) and morphology (electron microscopy) in placentas of forty-seven singleton pregnancies at elective cesarean section. Thirty-seven women were normoglycemic: twenty-one normal-weight women, NW, and sixteen obese women, OB/GDM(-). Ten obese women had gestational diabetes mellitus, OB/GDM(+). OB/GDM(-) presented higher mtDNA levels versus NW, suggesting increased mitochondrial biogenesis in the normoglycemic obese group. These mitochondria showed similar morphology to NW. On the contrary, in OB/GDM(+), mtDNA was not significantly increased versus NW. Nevertheless, mitochondria showed morphological abnormalities, indicating impaired functionality. The metabolic response of the placenta to impairment in obese pregnancies can possibly vary depending on several parameters, resulting in opposite strains acting when insulin resistance of GDM occurs in the obese environment, characterized by inflammation and oxidative stress. Therefore, mitochondrial alterations represent a feature of obese pregnancies with changes in placental energetics that possibly can affect pregnancy outcomes. © 2018 Chiara Mandò et al.
Original languageEnglish
Article number2378189
JournalOxidative Medicine and Cellular Longevity
Volume2018
DOIs
Publication statusPublished - 2018

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Mitochondria
Mitochondrial DNA
Hyperglycemia
Obesity
Oxidative stress
Pregnancy Outcome
Pregnancy
Placenta
Oxidative Stress
Mothers
Inflammation
Gestational Diabetes
Organelle Biogenesis
Medical problems
Cesarean Section
Electron microscopy
Insulin Resistance
Real-Time Polymerase Chain Reaction
Reactive Oxygen Species
Electron Microscopy

Cite this

Mandò, C., Anelli, GM., Novielli, C., Panina-Bordignon, P., Massari, M., Mazzocco, MI., & Cetin, I. (2018). Impact of obesity and hyperglycemia on placental mitochondria. Oxidative Medicine and Cellular Longevity, 2018, [2378189]. https://doi.org/10.1155/2018/2378189

Impact of obesity and hyperglycemia on placental mitochondria. / Mandò, C; Anelli, GM; Novielli, C; Panina-Bordignon, P; Massari, M; Mazzocco, MI; Cetin, Irene.

In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 2378189, 2018.

Research output: Contribution to journalArticle

Mandò, C, Anelli, GM, Novielli, C, Panina-Bordignon, P, Massari, M, Mazzocco, MI & Cetin, I 2018, 'Impact of obesity and hyperglycemia on placental mitochondria', Oxidative Medicine and Cellular Longevity, vol. 2018, 2378189. https://doi.org/10.1155/2018/2378189
Mandò C, Anelli GM, Novielli C, Panina-Bordignon P, Massari M, Mazzocco MI et al. Impact of obesity and hyperglycemia on placental mitochondria. Oxidative Medicine and Cellular Longevity. 2018;2018. 2378189. https://doi.org/10.1155/2018/2378189
Mandò, C ; Anelli, GM ; Novielli, C ; Panina-Bordignon, P ; Massari, M ; Mazzocco, MI ; Cetin, Irene. / Impact of obesity and hyperglycemia on placental mitochondria. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018.
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