Impact of Obesity on Perioperative Outcomes at Robotic-assisted and Open Radical Prostatectomy: Results From the National Inpatient Sample

S Knipper, E Mazzone, FA Mistretta, C Palumbo, Z Tian, A Briganti, F Saad, D Tilki, M Graefen, PI Karakiewicz

Research output: Contribution to journalArticle

Abstract

Objective: To test the effect of obesity (body mass index ≥30 kg/m2) on perioperative outcomes and total hospital charges at robot-assisted vs open radical prostatectomy (RARP vs ORP). Methods: Within the National Inpatient Sample database (2008-2015), we identified obese vs nonobese RARP and ORP patients. Estimated annual percent changes, multivariable logistic regression and linear regression models were used. All models were adjusted for clustering and weighted. Results: Of all, 53,626 (60%) underwent RARP vs 35,757 (40%) underwent ORP. At RARP, 8.6% were obese vs 6.9% at ORP. RARP rate increased significantly over time (12.5%-81.5%). Obesity rate increased significantly over time at both, RARP (5.1%-10.5%) and ORP (5.4%-10.7%). In multivariable logistic regression models, obesity predicted 5 of 11 unfavourable perioperative complications at RARP (odds ratio: 1.6-1.8) and 9 of 11 at ORP (odds ratio: 1.3-2.8). In linear regression models, obesity significantly added to total hospital charges at RARP (740$) and ORP (312$). Conclusion: Obesity may predispose to higher rates of adverse outcomes at RP. Its effect varies according to surgical approach. © 2019 Elsevier Inc.
Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalUrology
Volume133
DOIs
Publication statusPublished - 2019

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    Knipper, S., Mazzone, E., Mistretta, FA., Palumbo, C., Tian, Z., Briganti, A., Saad, F., Tilki, D., Graefen, M., & Karakiewicz, PI. (2019). Impact of Obesity on Perioperative Outcomes at Robotic-assisted and Open Radical Prostatectomy: Results From the National Inpatient Sample. Urology, 133, 135-144. https://doi.org/10.1016/j.urology.2019.05.053