Impact of passive smoke and/or atopy on adenoid immunoglobulin production in children

Sara Carlotta Tagliacarne, Chiara Valsecchi, Anna Maria Castellazzi, Amelia Licari, Catherine Klersy, Lorenza Montagna, Riccardo Castagnoli, Marco Benazzo, Giorgio Ciprandi, Gian Luigi Marseglia

Research output: Contribution to journalArticlepeer-review

Abstract

The adenoids are exposed to a wide number and variety of microbes, environmental pollutants, and food antigens. Atopy and passive smoke may significantly affect immune responses, mainly in children. The aim of the present study was to investigate whether passive exposure to tobacco smoke and/or atopy could affect immunoglobulin production by adenoidal lymphocytes in a cohort of children presenting with adenoid hypertrophy. A total of 277 children (151 males and 126 females; median age 5.5 years), with adenoidal hypertrophy requiring adenoidectomy and or adeno-tonsillectomy, were consecutively enrolled in the study. Adenoid mononuclear cells were in vitro stimulated with LPS or CpG. When considering both the presence of smoke exposure and atopy, we observed that the CpG-induced decrease in IgA and IgM production was significantly associated with this combination of risk factors. In the T-independent immunoglobulin production assay we found a positive association between the two risk factors and IgA and IgM production. In particular, the presence of both risk factors, showed a significant increase in IgA and IgM production after stimulation.In conclusion, this is the first study that investigated the in vitro adenoidal B cell response after different stimuli in children, also evaluating possible exposure to passive smoke and/or an atopic condition.

Original languageEnglish
Pages (from-to)70-77
Number of pages8
JournalImmunology Letters
Volume165
Issue number2
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Adenoidectomy
  • Adenoids
  • Atopy
  • Immunoglobulins
  • Mucosal immunity
  • Passive smoke

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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