Abstract
Objective To determine the association between peri-operative blood transfusion (PBT) and oncological outcomes in a large multi-institutional cohort of patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). Patients and Methods We conducted a retrospective analysis of 2895 patients treated with RC for UCB. Univariable and multivariable Cox regression models were used to analyse the effect of PBT administration on disease recurrence, cancer-specific mortality, and any-cause mortality. Results Patients' median (interquartile range [IQR]) age was 67 (60, 73) years and the median (IQR) follow-up was 36.1 (15, 84) months. Patients who received PBT were more likely to have advanced disease (P <0.001), high grade tumours (P = 0.047) and nodal metastasis (P = 0.004). PBT was associated with a higher risk of disease recurrence (P = 0.003), cancer-specific mortality (P = 0.017), and any-cause mortality (P = 0.010) in univariable, but not multivariable, analyses (P > 0.05). In multivariable analyses, pathological tumour stage, pathological nodal stage, soft tissue surgical margin, lymphovascular invasion and administration of adjuvant chemotherapy were independent predictors of disease recurrence, cancer-specific mortality and any-cause mortality (all P values
| Original language | English |
|---|---|
| Pages (from-to) | 393-398 |
| Number of pages | 6 |
| Journal | BJU International |
| Volume | 113 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2014 |
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Keywords
- bladder carcinoma
- blood transfusion
- outcomes
- prognosis
- radical cystectomy
- urothelial carcinoma
ASJC Scopus subject areas
- Urology
Cite this
Impact of peri-operative blood transfusion on the outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder. / Kluth, Luis A.; Xylinas, Evanguelos; Rieken, Malte; El Ghouayel, Maya; Sun, Maxine; Karakiewicz, Pierre I.; Lotan, Yair; Chun, Felix K H; Boorjian, Stephen A.; Lee, Richard K.; Briganti, Alberto; Rouprêt, Morgan; Fisch, Margit; Scherr, Douglas S.; Shariat, Shahrokh F.
In: BJU International, Vol. 113, No. 3, 03.2014, p. 393-398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of peri-operative blood transfusion on the outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder
AU - Kluth, Luis A.
AU - Xylinas, Evanguelos
AU - Rieken, Malte
AU - El Ghouayel, Maya
AU - Sun, Maxine
AU - Karakiewicz, Pierre I.
AU - Lotan, Yair
AU - Chun, Felix K H
AU - Boorjian, Stephen A.
AU - Lee, Richard K.
AU - Briganti, Alberto
AU - Rouprêt, Morgan
AU - Fisch, Margit
AU - Scherr, Douglas S.
AU - Shariat, Shahrokh F.
PY - 2014/3
Y1 - 2014/3
N2 - Objective To determine the association between peri-operative blood transfusion (PBT) and oncological outcomes in a large multi-institutional cohort of patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). Patients and Methods We conducted a retrospective analysis of 2895 patients treated with RC for UCB. Univariable and multivariable Cox regression models were used to analyse the effect of PBT administration on disease recurrence, cancer-specific mortality, and any-cause mortality. Results Patients' median (interquartile range [IQR]) age was 67 (60, 73) years and the median (IQR) follow-up was 36.1 (15, 84) months. Patients who received PBT were more likely to have advanced disease (P <0.001), high grade tumours (P = 0.047) and nodal metastasis (P = 0.004). PBT was associated with a higher risk of disease recurrence (P = 0.003), cancer-specific mortality (P = 0.017), and any-cause mortality (P = 0.010) in univariable, but not multivariable, analyses (P > 0.05). In multivariable analyses, pathological tumour stage, pathological nodal stage, soft tissue surgical margin, lymphovascular invasion and administration of adjuvant chemotherapy were independent predictors of disease recurrence, cancer-specific mortality and any-cause mortality (all P values
AB - Objective To determine the association between peri-operative blood transfusion (PBT) and oncological outcomes in a large multi-institutional cohort of patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). Patients and Methods We conducted a retrospective analysis of 2895 patients treated with RC for UCB. Univariable and multivariable Cox regression models were used to analyse the effect of PBT administration on disease recurrence, cancer-specific mortality, and any-cause mortality. Results Patients' median (interquartile range [IQR]) age was 67 (60, 73) years and the median (IQR) follow-up was 36.1 (15, 84) months. Patients who received PBT were more likely to have advanced disease (P <0.001), high grade tumours (P = 0.047) and nodal metastasis (P = 0.004). PBT was associated with a higher risk of disease recurrence (P = 0.003), cancer-specific mortality (P = 0.017), and any-cause mortality (P = 0.010) in univariable, but not multivariable, analyses (P > 0.05). In multivariable analyses, pathological tumour stage, pathological nodal stage, soft tissue surgical margin, lymphovascular invasion and administration of adjuvant chemotherapy were independent predictors of disease recurrence, cancer-specific mortality and any-cause mortality (all P values
KW - bladder carcinoma
KW - blood transfusion
KW - outcomes
KW - prognosis
KW - radical cystectomy
KW - urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84896703145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896703145&partnerID=8YFLogxK
U2 - 10.1111/bju.12439
DO - 10.1111/bju.12439
M3 - Article
C2 - 24053618
AN - SCOPUS:84896703145
VL - 113
SP - 393
EP - 398
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 3
ER -