Impact of permanent pacemaker on mortality after transcatheter aortic valve implantation: The PRAGMATIC (Pooled Rotterdam-Milan-Toulouse in Collaboration) Pacemaker substudy

Gennaro Giustino, Robert M A Van Der Boon, Javier Molina Martin De Nicolas, Nicolas Dumonteil, Alaide Chieffo, Peter P T De Jaegere, Didier Tchetche, Bertrand Marcheix, Damien Millischer, Romain Cassagneau, Didier Carrié, Nicolas M. Van Mieghem, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: We sought to evaluate the impact of permanent pacemaker (PPM) implantation on two-year mortality and one-year left ventricular ejection fraction recovery (δLVEFR=one-year LVEF-baseline LVEF) after transcatheter aortic valve implantation (TAVI). Methods and results: We pooled patient-level data from four European institutions with significant TAVI volume. Outcomes were compared between patients without PPM (no-PPM), patients with PPM prior to TAVI (old-PPM) and patients with PPM implanted after TAVI (new-PPM). Out of 1,062 patients included in the pooled data set, 783 (73.7%) were in the no-PPM group, 164 (15.4%) in the new-PPM group and 115 (10.8%) in the old-PPM group. All-cause and cardiovascular mortality at two years were similar for patients with no-PPM and new-PPM (adjusted HR 1.11, 95% CI: 0.74-1.67; p=0.62; and adjusted HR 1.16, 95% CI: 0.68-1.98; p=0.59). Conversely, old-PPM was associated with increased risk of both all-cause and cardiovascular mortality vs. no-PPM. By multivariable analysis new-PPM did not affect LVEFR, while oldPPM did. We observed a multiplicative interaction, between new-PPM and post-procedural aortic regurgitation =1+ on two-year mortality and one-year LVEFR, with increased risk of death and impaired LVEFR in patients with new-PPM and post-procedural aortic regurgitation (PPAR) ≥1+ (both pinteraction<0.0001). Conclusions: In patients undergoing TAVI, the presence of a PPM at baseline yielded a negative effect on long-term prognosis while new-PPM did not. The combination of new-PPM with PPAR adversely impacts on survival and LV function recovery.

Original languageEnglish
Pages (from-to)1185-1193
Number of pages9
JournalEuroIntervention
Volume12
Issue number9
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • Left ventricular ejection fraction
  • Mortality
  • Pacemaker
  • TAVI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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