Impact of Phyllantus niruri and Lactobacillus amylovorus SGL 14 in a mouse model of dietary hyperoxaluria

L. Manna, E. Rizzi, E. Bafile, C. Macchi, M. Ruscica, R. Salini, E. Rossi, C. Panebianco, V. Pazienza, F. Federici

Research output: Contribution to journalArticlepeer-review


Hyperoxaluria is a pathological condition which affects long-term health of kidneys. The present study evaluates the impact of the combination of Lactobacillus amylovorus SGL 14 and the plant extract Phyllantus niruri (namely Phyllantin 14™) on dietary hyperoxaluria. Safety and efficacy of Phyllantin 14 have been evaluated in vivo. Mice C57BL6 fed a high-oxalate diet were compared to mice fed the same diet administered with Phyllantin 14 by gavage for 6 weeks. Control mice were fed a standard diet without oxalate. No adverse effects were associated to Phyllantin 14 supplementation, supporting its safety. Mice fed a high-oxalate diet developed significant hyperoxaluria and those administered with Phyllantin 14 showed a reduced level of urinary oxalate and a lower oxalate-to-creatinine ratio. Soluble and insoluble caecal oxalate were significantly lower in treated group, a finding in agreement with the colonisation study, i.e. mice were colonised with SGL 14 after 3 weeks. Microbiota analysis demonstrated that both oxalate diet and Phyllantin 14 can differently modulate the microbiota. In conclusion, our findings suggest that Phyllantin 14 supplementation represents a potential supportive approach for reducing urinary oxalate and/or for enhancing the efficacy of existing treatments.

Original languageEnglish
Pages (from-to)547-559
Number of pages13
JournalBeneficial microbes
Issue number6
Publication statusPublished - Oct 12 2020


  • Lactobacillus amylovorus
  • oxalate
  • Phillantus niruri
  • probiotics
  • urinary lithiasis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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