Impact of platelet phenotype on myocardial infarction

Zufar Gabbasov, Jan Sabo, Daniel Petrovic, Nieves Martell-Claros, Angela Zagatina, Igor Mrdovic, Rachele Ciccocioppo, Giuseppina Cristina Cangemi, Jan Klimas, Peter Kruzliak

Research output: Contribution to journalArticle

Abstract

In acute myocardial infarction patients the injured vascular wall triggers thrombus formation in the damage site. Fibrin fibers and blood cellular elements are the major components of thrombus formed in acute occlusion of coronary arteries. It has been established that the initial thrombus is primarily composed of activated platelets rapidly stabilized by fibrin fibers. This review highlights the role of platelet membrane phenotype in pathophysiology of myocardial infarction. Here, we regard platelet phenotype as quantitative and qualitative parameters of the plasma membrane outer surface, which are crucial for platelet participation in blood coagulation, development of local inflammation and tissue repair.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalBiomarkers
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

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Keywords

  • Acute coronary syndrome
  • Cardiovascular risk
  • Myocardial infarction
  • Platelet phenotype
  • Platelets

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Gabbasov, Z., Sabo, J., Petrovic, D., Martell-Claros, N., Zagatina, A., Mrdovic, I., Ciccocioppo, R., Cangemi, G. C., Klimas, J., & Kruzliak, P. (2015). Impact of platelet phenotype on myocardial infarction. Biomarkers, 20(1), 17-25. https://doi.org/10.3109/1354750X.2014.993707