Impact of pneumococcal conjugate vaccination on otitis media: A systematic review

Sylvia Taylor, Paola Marchisio, Anne Vergison, Julie Harriague, William P. Hausdorff, Mark Haggard

Research output: Contribution to journalArticlepeer-review


Acute otitis media (AOM) is a leading cause of visits to physicians and of antibiotic prescriptions for young children. We systematically reviewed studies on all-cause AOM episodes and physician visits in which impact was attributed to pneumococcal conjugate vaccines, either as efficacy or effectiveness. Of 18 relevant publications found, most used the 7-valent pneumococcal conjugate vaccine (7vCRM). The efficacy of 7vCRM against all-cause AOM episodes or visits was 0-9 in randomized trials and 17-23 in nonrandomized trials. In observational database studies, physician visits for AOM were already declining in the 3-5 years before 7vCRM introduction (mean change,-15; range, +14 to-24) and continued to decline afterward (mean,-19; range, +7 to-48). This vaccine provides some protection against OM, but other factors have also contributed to the recent decline in OM incidence. Future effectiveness studies should thus use better-controlled methods to estimate the true impact of vaccination on AOM.

Original languageEnglish
Pages (from-to)1765-1773
Number of pages9
JournalClinical Infectious Diseases
Issue number12
Publication statusPublished - Jun 15 2012

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

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