Impact of pneumococcal conjugate vaccination on otitis media: A systematic review

Sylvia Taylor, Paola Marchisio, Anne Vergison, Julie Harriague, William P. Hausdorff, Mark Haggard

Research output: Contribution to journalArticle

Abstract

Acute otitis media (AOM) is a leading cause of visits to physicians and of antibiotic prescriptions for young children. We systematically reviewed studies on all-cause AOM episodes and physician visits in which impact was attributed to pneumococcal conjugate vaccines, either as efficacy or effectiveness. Of 18 relevant publications found, most used the 7-valent pneumococcal conjugate vaccine (7vCRM). The efficacy of 7vCRM against all-cause AOM episodes or visits was 0-9 in randomized trials and 17-23 in nonrandomized trials. In observational database studies, physician visits for AOM were already declining in the 3-5 years before 7vCRM introduction (mean change,-15; range, +14 to-24) and continued to decline afterward (mean,-19; range, +7 to-48). This vaccine provides some protection against OM, but other factors have also contributed to the recent decline in OM incidence. Future effectiveness studies should thus use better-controlled methods to estimate the true impact of vaccination on AOM.

Original languageEnglish
Pages (from-to)1765-1773
Number of pages9
JournalClinical Infectious Diseases
Volume54
Issue number12
DOIs
Publication statusPublished - Jun 15 2012

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Otitis Media
Vaccination
Conjugate Vaccines
Pneumococcal Vaccines
Physicians
Observational Studies
Prescriptions
Publications
Vaccines
Databases
Anti-Bacterial Agents
Incidence

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Impact of pneumococcal conjugate vaccination on otitis media : A systematic review. / Taylor, Sylvia; Marchisio, Paola; Vergison, Anne; Harriague, Julie; Hausdorff, William P.; Haggard, Mark.

In: Clinical Infectious Diseases, Vol. 54, No. 12, 15.06.2012, p. 1765-1773.

Research output: Contribution to journalArticle

Taylor, S, Marchisio, P, Vergison, A, Harriague, J, Hausdorff, WP & Haggard, M 2012, 'Impact of pneumococcal conjugate vaccination on otitis media: A systematic review', Clinical Infectious Diseases, vol. 54, no. 12, pp. 1765-1773. https://doi.org/10.1093/cid/cis292
Taylor, Sylvia ; Marchisio, Paola ; Vergison, Anne ; Harriague, Julie ; Hausdorff, William P. ; Haggard, Mark. / Impact of pneumococcal conjugate vaccination on otitis media : A systematic review. In: Clinical Infectious Diseases. 2012 ; Vol. 54, No. 12. pp. 1765-1773.
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