Impatto della chemioterapia locoregionale preoperatoria con fluorodesossiuridina (FUDR) sulla chirurgia resettiva epatica.

Translated title of the contribution: Impact of preoperative locoregional chemotherapy with fluorodeoxyuridine on the outcome of liver resection

Marcella Arru, Luca Aldrighetti, Monica Ronzoni, Enzo Angeli, Roberto Caterini, Gianfranco Ferla

Research output: Contribution to journalArticle

Abstract

The aim of the study was to evaluate the effects of preoperative intra-arterial hepatic chemotherapy (IAHC) on the outcome of liver resections for hepatic metastases from colorectal cancer. Twelve patients (IAHC group) treated by IAHC with fluorodeoxyuridine (FUdR) and subsequent liver resection and 40 patients who underwent liver resection without preliminary IAHC (non-IAHC group) were analysed comparatively in terms of age, gender, concomitant diseases, previous abdominal surgery, type of hepatic resection, use of portal clamping, and associated surgical procedures. For the purposes of the study, length of operation, intraoperative blood losses, perioperative transfusions, length of hospitalisation, complications and mortality were also recorded. The two groups were comparable (p = n.s.) for those variables affecting the perioperative course. As regards the end points of the study, no significant differences were recorded in length of operation, intraoperative blood losses, perioperative transfusions [except for more postoperative plasma transfusions in the IAHC group (16.7% vs 5.0%, p = 0.009)] and postoperative complications (9.1% vs 17.5%, p = 0.415). Postoperative mortality consisted in one patient in the IAHC group. Postoperative hospitalization was significantly longer in the non-IAHC group (median: 8 vs 10, range: 6-13 vs 5-33 days; p = 0.004). IAHC does not negatively affect the outcome of subsequent liver resection.

Original languageItalian
Pages (from-to)811-818
Number of pages8
JournalChirurgia Italiana
Volume54
Issue number6
Publication statusPublished - Nov 2002

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Floxuridine
Drug Therapy
Liver
Hospitalization
Mortality

ASJC Scopus subject areas

  • Surgery

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Impatto della chemioterapia locoregionale preoperatoria con fluorodesossiuridina (FUDR) sulla chirurgia resettiva epatica. / Arru, Marcella; Aldrighetti, Luca; Ronzoni, Monica; Angeli, Enzo; Caterini, Roberto; Ferla, Gianfranco.

In: Chirurgia Italiana, Vol. 54, No. 6, 11.2002, p. 811-818.

Research output: Contribution to journalArticle

Arru, Marcella ; Aldrighetti, Luca ; Ronzoni, Monica ; Angeli, Enzo ; Caterini, Roberto ; Ferla, Gianfranco. / Impatto della chemioterapia locoregionale preoperatoria con fluorodesossiuridina (FUDR) sulla chirurgia resettiva epatica. In: Chirurgia Italiana. 2002 ; Vol. 54, No. 6. pp. 811-818.
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