Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury

Nino Stocchetti, A. Protti, M. Lattuada, S. Magnoni, L. Longhi, L. Ghisoni, M. Egidi, E. R. Zanier

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Postischaemic pyrexia exacerbates neuronal damage. Hyperthermia related cerebral changes have still not been well investigated in humans. Objective: To study how pyrexia affects neurochemistry and cerebral oxygenation after acute brain injury. Methods: 18 acutely brain injured patients were studied at the onset and resolution of febrile episodes (brain temperature ≥38.7°C). Intracranial pressure (ICP), brain tissue oxygen tension (PbrO2)/ and brain tissue temperature (Tbr) were recorded continuously; jugular venous blood was sampled intermittently. Microdialysis probes were inserted in the cerebral cortex and in subcutaneous tissue. Glucose, lactate, pyruvate, and glutamate were measured hourly. The lactate to pyruvate ratio was calculated. Results: Mean (SD) Tbr rose from 38 (0.5) to 39.3 (0.3) °C. Arteriojugular oxygen content difference (AJDO2) fell from 4.2 (0.7) to 3.8 (0.5) vol% (pbrO2 rose from 32 (21) to 37 (22) mm Hg (p

Original languageEnglish
Pages (from-to)1135-1139
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume76
Issue number8
DOIs
Publication statusPublished - Aug 2005

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Neurochemistry
Brain Injuries
Fever
Brain
Pyruvic Acid
Lactic Acid
Oxygen
Temperature
Subcutaneous Tissue
Microdialysis
Intracranial Pressure
Cerebral Cortex
Glutamic Acid
Neck
Glucose

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury. / Stocchetti, Nino; Protti, A.; Lattuada, M.; Magnoni, S.; Longhi, L.; Ghisoni, L.; Egidi, M.; Zanier, E. R.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 76, No. 8, 08.2005, p. 1135-1139.

Research output: Contribution to journalArticle

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AU - Ghisoni, L.

AU - Egidi, M.

AU - Zanier, E. R.

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