Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients

Results from the GUARD-C Cohort

Graham Foster, Carmine Coppola, Moutaz Derbala, P. Ferenci, Alessandra Orlandini, K. Rajender Reddy, Ludovico Tallarico, Mitchell L. Shiffman, Silke Ahlers, Georgios Bakalos, Tarek Hassanein, Jovan Basho, Gentian Shabanaj, Arjan Harxhi, Nabil Debzi, Nawel Afredj, Nawal Guessab, Nadir Mahindad, Hassene Mahiou, Magda Aissaoui & 284 others Jihad Al Qameesh, Zuhal Al Ghandoor, Collins Assene, Boris Bastens, Christian Brixko, Mike Cool, Chantal De Galocsy, J. Delwaide, Christophe George, Pierre Laukens, Veronique Lefebvre, Jean Pierre Mulkay, Frederik Nevens, Benoit Servais, H. Van Vlierberghe, Y. Horsmans, Jean Henrion, Dirk Sprengers, P. Michielsen, Stefan Bourgeois, L. Lasser, P. Langlet, Geert Robaeys, Jean Paul Martinet, Philippe Warzee, Paul Hoste, Hendrik Reynaert, Irène Juriens, Jochen Decaestecker, Filip Van Der Meersch, Filip Janssens, Sead Ahmetagic, Antonija Verhaz, Milenko Bevanda, Lejla Calkic, Nevzeta Ibrahimpasic, Rusmir Mesihovic, Carlos Eduardo Mello, Fernando Jose Ruiz, Elson Martins Junior, Maria Lucia Ferraz, Giovanni Silva, Claudio Mendes, Andre Lyra, Mariliza Henrique Silva, Geisa Gomide, Julio Cesar Fernandes, Patricia Pereira, Maria Cassia Correa, Rosangela Teixeira, Ayman Yousry, Abdelfatah Hanno, Mamdouh Gabr, Ashraf Omar, G. Esmat, Stilianos Karatapanis, Vassiliki Nikolopoulou, Grigoris Giannoulis, Spilios Manolakopoulos, Ioannis Elefsiniotis, Christos Drakoulis, Dimitrios Dimitroulopoulos, Stilianos Kanatakis, Ioannis Ketikoglou, Konstantinos Mimidis, Nikolaos Evgenidis, Euaggelos Akriviades, Irini Vafiadi-Zoubouli, Epameinondas Tsianos, M. Mela, Eleni Orfanou, Georgios Mousoulis, Ioannis Karagiannis, Emmanuel Manesis, Marta Varga, Elemér Nemesánszky, Katalin Fried, János Schuller, Ferenc Szalay, Gabriella Lengyel, Istvan Tornai, Tivadar Bányai, Miklos Lesch, Istvan Nagy, Judit Gervain, Anna Tusnadi, Ferenc Schneider, László Szentgyörgyi, Bela Hunyady, Aron Vincze, Gyula Tolvaj, Istvan Varkonyi, Erzsébet Makkai, Judit Enyedi, Istvan Racz, Péter Hausinger, Zsuzsanna Váczi, Árpád Patai, Zsófia Ozsvár, Lilla Lakner, Pál Ribiczey, Ajay Bhalla, Sanjay Somani, Rosang Luaia, Padaki Rao, Mathew Philip, Parimal Lawate, Aabha Nagral, Ajit Sood, Samir Parikh, Shahin Merat, Mohsen Nassiri-Toosi, Seyed Moayed Alavian, M. Zali, Nasser Ebrahimi Daryani, D. Drenaggi, Adolfo F. Attili, Franco Bandiera, Paolo Bassi, G. Bellati, Stefano Bellantani, M. R. Brunetto, Savino Bruno, Francesco Castelli, Roberto Castellacci, A. Cattelan, Massimo Colombo, Antonio Craxi, Salvatore D'angelo, Silvia Colombo, Luigi Demelia, Giovanni Di Perri, Antonio Di Giacomo, Carlo Ferrari, D. Francisci, Katia Casinelli, Roberto Ganga, Chiara Costa, Alessandra Mangia, Francesco Paolo Russo, Filippo Matarazzo, Giuseppe Mazzella, Maurizio Mazzeo, Massimo Memoli, Marzia Montalbano, G. Montalto, Alessandro Pieri, Nicola Passariello, A. Picciotto, Antonello Pietrangelo, Mario Pirisi, T. Quirino, G. Raimondo, Gianludovico Rapaccini, G. Rizzardini, Mario Rizzetto, M. Russello, G. Sabusco, Teresa Santantonio, Giorgio Soardo, Alessandri Amedea, G. Verucchi, Francesco Vinelli, Anna Linda Zignego, Massimo Zuin, Antonio Ascione, Maria Vinci, Maria Graziella Pigozzi, Paolo Tundo, Giorgio Saracco, Pietro Amoroso, M. Andreoni, C. Colletta, Elke Erne, Angelo Salomone Megna, A. Biglino, P. G. Chiriacò, Giuseppe Foti, Giancarlo Spinzi, Emilio D'amico, Seung Woon Paik, Sang Hoon Ahn, Yun Nah Lee, Yoonjun Kim, Jinmo Yang, Sang Young Han, Rosh Varghese, Abeer Al Gharabally, Haifa Askar, Ala Sharara, Cesar Yaghi, Antoine Abou Rached, Zaher Houmani, Fouad Zaarour, Ahmad Dohaibi, Ljubomir Ivanovski, Nenad Joksimovic, Zaigham Abbas, Sadik Memon, Aftab Mohsin, Siddiq Masood, Zahid Hashmi, Waldemar Halota, Zbigniew Deron, Wlodzimierz Mazur, R. Flisiak, Artur Lipczynski, Joanna Musialik, Anna Piekarska, Krystyna Augustyniak, Barbara Baka-Cwierz, Krzysztof Simon, Andrzej Gietka, Hanna Berak, Jerzy Sieklucki, Danuta Radowska, Bronislawa Szlauer, Tomasz Piekos, Iwona Olszok, Maciej Jablkowski, Grazyna Orszulak, Iwona Warakomska, Maria João Aleixo, Cristina Valente, Guilherme Macedo, Rui Sarmento-Castro, Fausto Roxo, Telo Faria, K. Mansinho, Jorge Velez, José Presa Ramos, Horácio Guerreiro, Sara Alberto, Carlos Monteverde, F. Serejo, Paula Peixe, José Malhado, Manuela Curescu, A. Streinu-Cercel, Florin Caruntu, Hara Livia, Liliana Preotescu, Victoria Arama, Ioan Ancuta, Liana Gheorghe, Carol Stanciu, A. Trifan, Monica Acalovschi, Vasile Andreica, Oliviu Pascu, Monica Lencu, Ioan Sporea, Dan Olteanu, Florentina Ionita-Radu, Carmen Fierbinteanu-Braticevici, Adriana Motoc, Rodica Silaghi, Marioara Musat, Felicia Coman, Marioara Stan, Cristina Cijevschi, Egidia Miftode, Dragan Delic, Rada Jesic, Darko Nozic, Petar Svorcan, Milotka Fabri, Ljiljana Konstantinovic, Mijomir Pelemis, Goran Jankovic, Zoran Todorovic, Aleksandar Nagorni, Viera Kupcova, Lubomir Skladany, Maria Szantova, Dusan Krkoska, Peter Jarcuska, Ivan Schreter, Marian Oltman, Jana Bocakova, Ivan Bunganic, Jozef Holoman, Alain Giguere, Ahmed Mohamed Saleh Abdou

Research output: Contribution to journalArticle

Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Original languageEnglish
Article numbere0151703
JournalPLoS One
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Hepatitis C virus
Ribavirin
Viruses
Hepacivirus
Safety
dosage
Patient treatment
chronic hepatitis C
antiviral agents
Chronic Hepatitis C
Virus Diseases
physicians
Antiviral Agents
RNA
Physicians
infection
Sustained Virologic Response
Therapeutics
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients : Results from the GUARD-C Cohort. / Foster, Graham; Coppola, Carmine; Derbala, Moutaz; Ferenci, P.; Orlandini, Alessandra; Reddy, K. Rajender; Tallarico, Ludovico; Shiffman, Mitchell L.; Ahlers, Silke; Bakalos, Georgios; Hassanein, Tarek; Basho, Jovan; Shabanaj, Gentian; Harxhi, Arjan; Debzi, Nabil; Afredj, Nawel; Guessab, Nawal; Mahindad, Nadir; Mahiou, Hassene; Aissaoui, Magda; Al Qameesh, Jihad; Al Ghandoor, Zuhal; Assene, Collins; Bastens, Boris; Brixko, Christian; Cool, Mike; De Galocsy, Chantal; Delwaide, J.; George, Christophe; Laukens, Pierre; Lefebvre, Veronique; Mulkay, Jean Pierre; Nevens, Frederik; Servais, Benoit; Van Vlierberghe, H.; Horsmans, Y.; Henrion, Jean; Sprengers, Dirk; Michielsen, P.; Bourgeois, Stefan; Lasser, L.; Langlet, P.; Robaeys, Geert; Martinet, Jean Paul; Warzee, Philippe; Hoste, Paul; Reynaert, Hendrik; Juriens, Irène; Decaestecker, Jochen; Van Der Meersch, Filip; Janssens, Filip; Ahmetagic, Sead; Verhaz, Antonija; Bevanda, Milenko; Calkic, Lejla; Ibrahimpasic, Nevzeta; Mesihovic, Rusmir; Mello, Carlos Eduardo; Ruiz, Fernando Jose; Junior, Elson Martins; Ferraz, Maria Lucia; Silva, Giovanni; Mendes, Claudio; Lyra, Andre; Silva, Mariliza Henrique; Gomide, Geisa; Fernandes, Julio Cesar; Pereira, Patricia; Correa, Maria Cassia; Teixeira, Rosangela; Yousry, Ayman; Hanno, Abdelfatah; Gabr, Mamdouh; Omar, Ashraf; Esmat, G.; Karatapanis, Stilianos; Nikolopoulou, Vassiliki; Giannoulis, Grigoris; Manolakopoulos, Spilios; Elefsiniotis, Ioannis; Drakoulis, Christos; Dimitroulopoulos, Dimitrios; Kanatakis, Stilianos; Ketikoglou, Ioannis; Mimidis, Konstantinos; Evgenidis, Nikolaos; Akriviades, Euaggelos; Vafiadi-Zoubouli, Irini; Tsianos, Epameinondas; Mela, M.; Orfanou, Eleni; Mousoulis, Georgios; Karagiannis, Ioannis; Manesis, Emmanuel; Varga, Marta; Nemesánszky, Elemér; Fried, Katalin; Schuller, János; Szalay, Ferenc; Lengyel, Gabriella; Tornai, Istvan; Bányai, Tivadar; Lesch, Miklos; Nagy, Istvan; Gervain, Judit; Tusnadi, Anna; Schneider, Ferenc; Szentgyörgyi, László; Hunyady, Bela; Vincze, Aron; Tolvaj, Gyula; Varkonyi, Istvan; Makkai, Erzsébet; Enyedi, Judit; Racz, Istvan; Hausinger, Péter; Váczi, Zsuzsanna; Patai, Árpád; Ozsvár, Zsófia; Lakner, Lilla; Ribiczey, Pál; Bhalla, Ajay; Somani, Sanjay; Luaia, Rosang; Rao, Padaki; Philip, Mathew; Lawate, Parimal; Nagral, Aabha; Sood, Ajit; Parikh, Samir; Merat, Shahin; Nassiri-Toosi, Mohsen; Alavian, Seyed Moayed; Zali, M.; Daryani, Nasser Ebrahimi; Drenaggi, D.; Attili, Adolfo F.; Bandiera, Franco; Bassi, Paolo; Bellati, G.; Bellantani, Stefano; Brunetto, M. R.; Bruno, Savino; Castelli, Francesco; Castellacci, Roberto; Cattelan, A.; Colombo, Massimo; Craxi, Antonio; D'angelo, Salvatore; Colombo, Silvia; Demelia, Luigi; Di Perri, Giovanni; Di Giacomo, Antonio; Ferrari, Carlo; Francisci, D.; Casinelli, Katia; Ganga, Roberto; Costa, Chiara; Mangia, Alessandra; Russo, Francesco Paolo; Matarazzo, Filippo; Mazzella, Giuseppe; Mazzeo, Maurizio; Memoli, Massimo; Montalbano, Marzia; Montalto, G.; Pieri, Alessandro; Passariello, Nicola; Picciotto, A.; Pietrangelo, Antonello; Pirisi, Mario; Quirino, T.; Raimondo, G.; Rapaccini, Gianludovico; Rizzardini, G.; Rizzetto, Mario; Russello, M.; Sabusco, G.; Santantonio, Teresa; Soardo, Giorgio; Amedea, Alessandri; Verucchi, G.; Vinelli, Francesco; Zignego, Anna Linda; Zuin, Massimo; Ascione, Antonio; Vinci, Maria; Pigozzi, Maria Graziella; Tundo, Paolo; Saracco, Giorgio; Amoroso, Pietro; Andreoni, M.; Colletta, C.; Erne, Elke; Megna, Angelo Salomone; Biglino, A.; Chiriacò, P. G.; Foti, Giuseppe; Spinzi, Giancarlo; D'amico, Emilio; Paik, Seung Woon; Ahn, Sang Hoon; Lee, Yun Nah; Kim, Yoonjun; Yang, Jinmo; Han, Sang Young; Varghese, Rosh; Al Gharabally, Abeer; Askar, Haifa; Sharara, Ala; Yaghi, Cesar; Abou Rached, Antoine; Houmani, Zaher; Zaarour, Fouad; Dohaibi, Ahmad; Ivanovski, Ljubomir; Joksimovic, Nenad; Abbas, Zaigham; Memon, Sadik; Mohsin, Aftab; Masood, Siddiq; Hashmi, Zahid; Halota, Waldemar; Deron, Zbigniew; Mazur, Wlodzimierz; Flisiak, R.; Lipczynski, Artur; Musialik, Joanna; Piekarska, Anna; Augustyniak, Krystyna; Baka-Cwierz, Barbara; Simon, Krzysztof; Gietka, Andrzej; Berak, Hanna; Sieklucki, Jerzy; Radowska, Danuta; Szlauer, Bronislawa; Piekos, Tomasz; Olszok, Iwona; Jablkowski, Maciej; Orszulak, Grazyna; Warakomska, Iwona; Aleixo, Maria João; Valente, Cristina; Macedo, Guilherme; Sarmento-Castro, Rui; Roxo, Fausto; Faria, Telo; Mansinho, K.; Velez, Jorge; Ramos, José Presa; Guerreiro, Horácio; Alberto, Sara; Monteverde, Carlos; Serejo, F.; Peixe, Paula; Malhado, José; Curescu, Manuela; Streinu-Cercel, A.; Caruntu, Florin; Livia, Hara; Preotescu, Liliana; Arama, Victoria; Ancuta, Ioan; Gheorghe, Liana; Stanciu, Carol; Trifan, A.; Acalovschi, Monica; Andreica, Vasile; Pascu, Oliviu; Lencu, Monica; Sporea, Ioan; Olteanu, Dan; Ionita-Radu, Florentina; Fierbinteanu-Braticevici, Carmen; Motoc, Adriana; Silaghi, Rodica; Musat, Marioara; Coman, Felicia; Stan, Marioara; Cijevschi, Cristina; Miftode, Egidia; Delic, Dragan; Jesic, Rada; Nozic, Darko; Svorcan, Petar; Fabri, Milotka; Konstantinovic, Ljiljana; Pelemis, Mijomir; Jankovic, Goran; Todorovic, Zoran; Nagorni, Aleksandar; Kupcova, Viera; Skladany, Lubomir; Szantova, Maria; Krkoska, Dusan; Jarcuska, Peter; Schreter, Ivan; Oltman, Marian; Bocakova, Jana; Bunganic, Ivan; Holoman, Jozef; Giguere, Alain; Abdou, Ahmed Mohamed Saleh.

In: PLoS One, Vol. 11, No. 3, e0151703, 01.03.2016.

Research output: Contribution to journalArticle

Foster, G, Coppola, C, Derbala, M, Ferenci, P, Orlandini, A, Reddy, KR, Tallarico, L, Shiffman, ML, Ahlers, S, Bakalos, G, Hassanein, T, Basho, J, Shabanaj, G, Harxhi, A, Debzi, N, Afredj, N, Guessab, N, Mahindad, N, Mahiou, H, Aissaoui, M, Al Qameesh, J, Al Ghandoor, Z, Assene, C, Bastens, B, Brixko, C, Cool, M, De Galocsy, C, Delwaide, J, George, C, Laukens, P, Lefebvre, V, Mulkay, JP, Nevens, F, Servais, B, Van Vlierberghe, H, Horsmans, Y, Henrion, J, Sprengers, D, Michielsen, P, Bourgeois, S, Lasser, L, Langlet, P, Robaeys, G, Martinet, JP, Warzee, P, Hoste, P, Reynaert, H, Juriens, I, Decaestecker, J, Van Der Meersch, F, Janssens, F, Ahmetagic, S, Verhaz, A, Bevanda, M, Calkic, L, Ibrahimpasic, N, Mesihovic, R, Mello, CE, Ruiz, FJ, Junior, EM, Ferraz, ML, Silva, G, Mendes, C, Lyra, A, Silva, MH, Gomide, G, Fernandes, JC, Pereira, P, Correa, MC, Teixeira, R, Yousry, A, Hanno, A, Gabr, M, Omar, A, Esmat, G, Karatapanis, S, Nikolopoulou, V, Giannoulis, G, Manolakopoulos, S, Elefsiniotis, I, Drakoulis, C, Dimitroulopoulos, D, Kanatakis, S, Ketikoglou, I, Mimidis, K, Evgenidis, N, Akriviades, E, Vafiadi-Zoubouli, I, Tsianos, E, Mela, M, Orfanou, E, Mousoulis, G, Karagiannis, I, Manesis, E, Varga, M, Nemesánszky, E, Fried, K, Schuller, J, Szalay, F, Lengyel, G, Tornai, I, Bányai, T, Lesch, M, Nagy, I, Gervain, J, Tusnadi, A, Schneider, F, Szentgyörgyi, L, Hunyady, B, Vincze, A, Tolvaj, G, Varkonyi, I, Makkai, E, Enyedi, J, Racz, I, Hausinger, P, Váczi, Z, Patai, Á, Ozsvár, Z, Lakner, L, Ribiczey, P, Bhalla, A, Somani, S, Luaia, R, Rao, P, Philip, M, Lawate, P, Nagral, A, Sood, A, Parikh, S, Merat, S, Nassiri-Toosi, M, Alavian, SM, Zali, M, Daryani, NE, Drenaggi, D, Attili, AF, Bandiera, F, Bassi, P, Bellati, G, Bellantani, S, Brunetto, MR, Bruno, S, Castelli, F, Castellacci, R, Cattelan, A, Colombo, M, Craxi, A, D'angelo, S, Colombo, S, Demelia, L, Di Perri, G, Di Giacomo, A, Ferrari, C, Francisci, D, Casinelli, K, Ganga, R, Costa, C, Mangia, A, Russo, FP, Matarazzo, F, Mazzella, G, Mazzeo, M, Memoli, M, Montalbano, M, Montalto, G, Pieri, A, Passariello, N, Picciotto, A, Pietrangelo, A, Pirisi, M, Quirino, T, Raimondo, G, Rapaccini, G, Rizzardini, G, Rizzetto, M, Russello, M, Sabusco, G, Santantonio, T, Soardo, G, Amedea, A, Verucchi, G, Vinelli, F, Zignego, AL, Zuin, M, Ascione, A, Vinci, M, Pigozzi, MG, Tundo, P, Saracco, G, Amoroso, P, Andreoni, M, Colletta, C, Erne, E, Megna, AS, Biglino, A, Chiriacò, PG, Foti, G, Spinzi, G, D'amico, E, Paik, SW, Ahn, SH, Lee, YN, Kim, Y, Yang, J, Han, SY, Varghese, R, Al Gharabally, A, Askar, H, Sharara, A, Yaghi, C, Abou Rached, A, Houmani, Z, Zaarour, F, Dohaibi, A, Ivanovski, L, Joksimovic, N, Abbas, Z, Memon, S, Mohsin, A, Masood, S, Hashmi, Z, Halota, W, Deron, Z, Mazur, W, Flisiak, R, Lipczynski, A, Musialik, J, Piekarska, A, Augustyniak, K, Baka-Cwierz, B, Simon, K, Gietka, A, Berak, H, Sieklucki, J, Radowska, D, Szlauer, B, Piekos, T, Olszok, I, Jablkowski, M, Orszulak, G, Warakomska, I, Aleixo, MJ, Valente, C, Macedo, G, Sarmento-Castro, R, Roxo, F, Faria, T, Mansinho, K, Velez, J, Ramos, JP, Guerreiro, H, Alberto, S, Monteverde, C, Serejo, F, Peixe, P, Malhado, J, Curescu, M, Streinu-Cercel, A, Caruntu, F, Livia, H, Preotescu, L, Arama, V, Ancuta, I, Gheorghe, L, Stanciu, C, Trifan, A, Acalovschi, M, Andreica, V, Pascu, O, Lencu, M, Sporea, I, Olteanu, D, Ionita-Radu, F, Fierbinteanu-Braticevici, C, Motoc, A, Silaghi, R, Musat, M, Coman, F, Stan, M, Cijevschi, C, Miftode, E, Delic, D, Jesic, R, Nozic, D, Svorcan, P, Fabri, M, Konstantinovic, L, Pelemis, M, Jankovic, G, Todorovic, Z, Nagorni, A, Kupcova, V, Skladany, L, Szantova, M, Krkoska, D, Jarcuska, P, Schreter, I, Oltman, M, Bocakova, J, Bunganic, I, Holoman, J, Giguere, A & Abdou, AMS 2016, 'Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort', PLoS One, vol. 11, no. 3, e0151703. https://doi.org/10.1371/journal.pone.0151703
Foster, Graham ; Coppola, Carmine ; Derbala, Moutaz ; Ferenci, P. ; Orlandini, Alessandra ; Reddy, K. Rajender ; Tallarico, Ludovico ; Shiffman, Mitchell L. ; Ahlers, Silke ; Bakalos, Georgios ; Hassanein, Tarek ; Basho, Jovan ; Shabanaj, Gentian ; Harxhi, Arjan ; Debzi, Nabil ; Afredj, Nawel ; Guessab, Nawal ; Mahindad, Nadir ; Mahiou, Hassene ; Aissaoui, Magda ; Al Qameesh, Jihad ; Al Ghandoor, Zuhal ; Assene, Collins ; Bastens, Boris ; Brixko, Christian ; Cool, Mike ; De Galocsy, Chantal ; Delwaide, J. ; George, Christophe ; Laukens, Pierre ; Lefebvre, Veronique ; Mulkay, Jean Pierre ; Nevens, Frederik ; Servais, Benoit ; Van Vlierberghe, H. ; Horsmans, Y. ; Henrion, Jean ; Sprengers, Dirk ; Michielsen, P. ; Bourgeois, Stefan ; Lasser, L. ; Langlet, P. ; Robaeys, Geert ; Martinet, Jean Paul ; Warzee, Philippe ; Hoste, Paul ; Reynaert, Hendrik ; Juriens, Irène ; Decaestecker, Jochen ; Van Der Meersch, Filip ; Janssens, Filip ; Ahmetagic, Sead ; Verhaz, Antonija ; Bevanda, Milenko ; Calkic, Lejla ; Ibrahimpasic, Nevzeta ; Mesihovic, Rusmir ; Mello, Carlos Eduardo ; Ruiz, Fernando Jose ; Junior, Elson Martins ; Ferraz, Maria Lucia ; Silva, Giovanni ; Mendes, Claudio ; Lyra, Andre ; Silva, Mariliza Henrique ; Gomide, Geisa ; Fernandes, Julio Cesar ; Pereira, Patricia ; Correa, Maria Cassia ; Teixeira, Rosangela ; Yousry, Ayman ; Hanno, Abdelfatah ; Gabr, Mamdouh ; Omar, Ashraf ; Esmat, G. ; Karatapanis, Stilianos ; Nikolopoulou, Vassiliki ; Giannoulis, Grigoris ; Manolakopoulos, Spilios ; Elefsiniotis, Ioannis ; Drakoulis, Christos ; Dimitroulopoulos, Dimitrios ; Kanatakis, Stilianos ; Ketikoglou, Ioannis ; Mimidis, Konstantinos ; Evgenidis, Nikolaos ; Akriviades, Euaggelos ; Vafiadi-Zoubouli, Irini ; Tsianos, Epameinondas ; Mela, M. ; Orfanou, Eleni ; Mousoulis, Georgios ; Karagiannis, Ioannis ; Manesis, Emmanuel ; Varga, Marta ; Nemesánszky, Elemér ; Fried, Katalin ; Schuller, János ; Szalay, Ferenc ; Lengyel, Gabriella ; Tornai, Istvan ; Bányai, Tivadar ; Lesch, Miklos ; Nagy, Istvan ; Gervain, Judit ; Tusnadi, Anna ; Schneider, Ferenc ; Szentgyörgyi, László ; Hunyady, Bela ; Vincze, Aron ; Tolvaj, Gyula ; Varkonyi, Istvan ; Makkai, Erzsébet ; Enyedi, Judit ; Racz, Istvan ; Hausinger, Péter ; Váczi, Zsuzsanna ; Patai, Árpád ; Ozsvár, Zsófia ; Lakner, Lilla ; Ribiczey, Pál ; Bhalla, Ajay ; Somani, Sanjay ; Luaia, Rosang ; Rao, Padaki ; Philip, Mathew ; Lawate, Parimal ; Nagral, Aabha ; Sood, Ajit ; Parikh, Samir ; Merat, Shahin ; Nassiri-Toosi, Mohsen ; Alavian, Seyed Moayed ; Zali, M. ; Daryani, Nasser Ebrahimi ; Drenaggi, D. ; Attili, Adolfo F. ; Bandiera, Franco ; Bassi, Paolo ; Bellati, G. ; Bellantani, Stefano ; Brunetto, M. R. ; Bruno, Savino ; Castelli, Francesco ; Castellacci, Roberto ; Cattelan, A. ; Colombo, Massimo ; Craxi, Antonio ; D'angelo, Salvatore ; Colombo, Silvia ; Demelia, Luigi ; Di Perri, Giovanni ; Di Giacomo, Antonio ; Ferrari, Carlo ; Francisci, D. ; Casinelli, Katia ; Ganga, Roberto ; Costa, Chiara ; Mangia, Alessandra ; Russo, Francesco Paolo ; Matarazzo, Filippo ; Mazzella, Giuseppe ; Mazzeo, Maurizio ; Memoli, Massimo ; Montalbano, Marzia ; Montalto, G. ; Pieri, Alessandro ; Passariello, Nicola ; Picciotto, A. ; Pietrangelo, Antonello ; Pirisi, Mario ; Quirino, T. ; Raimondo, G. ; Rapaccini, Gianludovico ; Rizzardini, G. ; Rizzetto, Mario ; Russello, M. ; Sabusco, G. ; Santantonio, Teresa ; Soardo, Giorgio ; Amedea, Alessandri ; Verucchi, G. ; Vinelli, Francesco ; Zignego, Anna Linda ; Zuin, Massimo ; Ascione, Antonio ; Vinci, Maria ; Pigozzi, Maria Graziella ; Tundo, Paolo ; Saracco, Giorgio ; Amoroso, Pietro ; Andreoni, M. ; Colletta, C. ; Erne, Elke ; Megna, Angelo Salomone ; Biglino, A. ; Chiriacò, P. G. ; Foti, Giuseppe ; Spinzi, Giancarlo ; D'amico, Emilio ; Paik, Seung Woon ; Ahn, Sang Hoon ; Lee, Yun Nah ; Kim, Yoonjun ; Yang, Jinmo ; Han, Sang Young ; Varghese, Rosh ; Al Gharabally, Abeer ; Askar, Haifa ; Sharara, Ala ; Yaghi, Cesar ; Abou Rached, Antoine ; Houmani, Zaher ; Zaarour, Fouad ; Dohaibi, Ahmad ; Ivanovski, Ljubomir ; Joksimovic, Nenad ; Abbas, Zaigham ; Memon, Sadik ; Mohsin, Aftab ; Masood, Siddiq ; Hashmi, Zahid ; Halota, Waldemar ; Deron, Zbigniew ; Mazur, Wlodzimierz ; Flisiak, R. ; Lipczynski, Artur ; Musialik, Joanna ; Piekarska, Anna ; Augustyniak, Krystyna ; Baka-Cwierz, Barbara ; Simon, Krzysztof ; Gietka, Andrzej ; Berak, Hanna ; Sieklucki, Jerzy ; Radowska, Danuta ; Szlauer, Bronislawa ; Piekos, Tomasz ; Olszok, Iwona ; Jablkowski, Maciej ; Orszulak, Grazyna ; Warakomska, Iwona ; Aleixo, Maria João ; Valente, Cristina ; Macedo, Guilherme ; Sarmento-Castro, Rui ; Roxo, Fausto ; Faria, Telo ; Mansinho, K. ; Velez, Jorge ; Ramos, José Presa ; Guerreiro, Horácio ; Alberto, Sara ; Monteverde, Carlos ; Serejo, F. ; Peixe, Paula ; Malhado, José ; Curescu, Manuela ; Streinu-Cercel, A. ; Caruntu, Florin ; Livia, Hara ; Preotescu, Liliana ; Arama, Victoria ; Ancuta, Ioan ; Gheorghe, Liana ; Stanciu, Carol ; Trifan, A. ; Acalovschi, Monica ; Andreica, Vasile ; Pascu, Oliviu ; Lencu, Monica ; Sporea, Ioan ; Olteanu, Dan ; Ionita-Radu, Florentina ; Fierbinteanu-Braticevici, Carmen ; Motoc, Adriana ; Silaghi, Rodica ; Musat, Marioara ; Coman, Felicia ; Stan, Marioara ; Cijevschi, Cristina ; Miftode, Egidia ; Delic, Dragan ; Jesic, Rada ; Nozic, Darko ; Svorcan, Petar ; Fabri, Milotka ; Konstantinovic, Ljiljana ; Pelemis, Mijomir ; Jankovic, Goran ; Todorovic, Zoran ; Nagorni, Aleksandar ; Kupcova, Viera ; Skladany, Lubomir ; Szantova, Maria ; Krkoska, Dusan ; Jarcuska, Peter ; Schreter, Ivan ; Oltman, Marian ; Bocakova, Jana ; Bunganic, Ivan ; Holoman, Jozef ; Giguere, Alain ; Abdou, Ahmed Mohamed Saleh. / Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients : Results from the GUARD-C Cohort. In: PLoS One. 2016 ; Vol. 11, No. 3.
@article{2cc8749a0c51444592424327b1a51b4e,
title = "Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort",
abstract = "Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA",
author = "Graham Foster and Carmine Coppola and Moutaz Derbala and P. Ferenci and Alessandra Orlandini and Reddy, {K. Rajender} and Ludovico Tallarico and Shiffman, {Mitchell L.} and Silke Ahlers and Georgios Bakalos and Tarek Hassanein and Jovan Basho and Gentian Shabanaj and Arjan Harxhi and Nabil Debzi and Nawel Afredj and Nawal Guessab and Nadir Mahindad and Hassene Mahiou and Magda Aissaoui and {Al Qameesh}, Jihad and {Al Ghandoor}, Zuhal and Collins Assene and Boris Bastens and Christian Brixko and Mike Cool and {De Galocsy}, Chantal and J. Delwaide and Christophe George and Pierre Laukens and Veronique Lefebvre and Mulkay, {Jean Pierre} and Frederik Nevens and Benoit Servais and {Van Vlierberghe}, H. and Y. Horsmans and Jean Henrion and Dirk Sprengers and P. Michielsen and Stefan Bourgeois and L. Lasser and P. Langlet and Geert Robaeys and Martinet, {Jean Paul} and Philippe Warzee and Paul Hoste and Hendrik Reynaert and Ir{\`e}ne Juriens and Jochen Decaestecker and {Van Der Meersch}, Filip and Filip Janssens and Sead Ahmetagic and Antonija Verhaz and Milenko Bevanda and Lejla Calkic and Nevzeta Ibrahimpasic and Rusmir Mesihovic and Mello, {Carlos Eduardo} and Ruiz, {Fernando Jose} and Junior, {Elson Martins} and Ferraz, {Maria Lucia} and Giovanni Silva and Claudio Mendes and Andre Lyra and Silva, {Mariliza Henrique} and Geisa Gomide and Fernandes, {Julio Cesar} and Patricia Pereira and Correa, {Maria Cassia} and Rosangela Teixeira and Ayman Yousry and Abdelfatah Hanno and Mamdouh Gabr and Ashraf Omar and G. Esmat and Stilianos Karatapanis and Vassiliki Nikolopoulou and Grigoris Giannoulis and Spilios Manolakopoulos and Ioannis Elefsiniotis and Christos Drakoulis and Dimitrios Dimitroulopoulos and Stilianos Kanatakis and Ioannis Ketikoglou and Konstantinos Mimidis and Nikolaos Evgenidis and Euaggelos Akriviades and Irini Vafiadi-Zoubouli and Epameinondas Tsianos and M. Mela and Eleni Orfanou and Georgios Mousoulis and Ioannis Karagiannis and Emmanuel Manesis and Marta Varga and Elem{\'e}r Nemes{\'a}nszky and Katalin Fried and J{\'a}nos Schuller and Ferenc Szalay and Gabriella Lengyel and Istvan Tornai and Tivadar B{\'a}nyai and Miklos Lesch and Istvan Nagy and Judit Gervain and Anna Tusnadi and Ferenc Schneider and L{\'a}szl{\'o} Szentgy{\"o}rgyi and Bela Hunyady and Aron Vincze and Gyula Tolvaj and Istvan Varkonyi and Erzs{\'e}bet Makkai and Judit Enyedi and Istvan Racz and P{\'e}ter Hausinger and Zsuzsanna V{\'a}czi and {\'A}rp{\'a}d Patai and Zs{\'o}fia Ozsv{\'a}r and Lilla Lakner and P{\'a}l Ribiczey and Ajay Bhalla and Sanjay Somani and Rosang Luaia and Padaki Rao and Mathew Philip and Parimal Lawate and Aabha Nagral and Ajit Sood and Samir Parikh and Shahin Merat and Mohsen Nassiri-Toosi and Alavian, {Seyed Moayed} and M. Zali and Daryani, {Nasser Ebrahimi} and D. Drenaggi and Attili, {Adolfo F.} and Franco Bandiera and Paolo Bassi and G. Bellati and Stefano Bellantani and Brunetto, {M. R.} and Savino Bruno and Francesco Castelli and Roberto Castellacci and A. Cattelan and Massimo Colombo and Antonio Craxi and Salvatore D'angelo and Silvia Colombo and Luigi Demelia and {Di Perri}, Giovanni and {Di Giacomo}, Antonio and Carlo Ferrari and D. Francisci and Katia Casinelli and Roberto Ganga and Chiara Costa and Alessandra Mangia and Russo, {Francesco Paolo} and Filippo Matarazzo and Giuseppe Mazzella and Maurizio Mazzeo and Massimo Memoli and Marzia Montalbano and G. Montalto and Alessandro Pieri and Nicola Passariello and A. Picciotto and Antonello Pietrangelo and Mario Pirisi and T. Quirino and G. Raimondo and Gianludovico Rapaccini and G. Rizzardini and Mario Rizzetto and M. Russello and G. Sabusco and Teresa Santantonio and Giorgio Soardo and Alessandri Amedea and G. Verucchi and Francesco Vinelli and Zignego, {Anna Linda} and Massimo Zuin and Antonio Ascione and Maria Vinci and Pigozzi, {Maria Graziella} and Paolo Tundo and Giorgio Saracco and Pietro Amoroso and M. Andreoni and C. Colletta and Elke Erne and Megna, {Angelo Salomone} and A. Biglino and Chiriac{\`o}, {P. G.} and Giuseppe Foti and Giancarlo Spinzi and Emilio D'amico and Paik, {Seung Woon} and Ahn, {Sang Hoon} and Lee, {Yun Nah} and Yoonjun Kim and Jinmo Yang and Han, {Sang Young} and Rosh Varghese and {Al Gharabally}, Abeer and Haifa Askar and Ala Sharara and Cesar Yaghi and {Abou Rached}, Antoine and Zaher Houmani and Fouad Zaarour and Ahmad Dohaibi and Ljubomir Ivanovski and Nenad Joksimovic and Zaigham Abbas and Sadik Memon and Aftab Mohsin and Siddiq Masood and Zahid Hashmi and Waldemar Halota and Zbigniew Deron and Wlodzimierz Mazur and R. Flisiak and Artur Lipczynski and Joanna Musialik and Anna Piekarska and Krystyna Augustyniak and Barbara Baka-Cwierz and Krzysztof Simon and Andrzej Gietka and Hanna Berak and Jerzy Sieklucki and Danuta Radowska and Bronislawa Szlauer and Tomasz Piekos and Iwona Olszok and Maciej Jablkowski and Grazyna Orszulak and Iwona Warakomska and Aleixo, {Maria Jo{\~a}o} and Cristina Valente and Guilherme Macedo and Rui Sarmento-Castro and Fausto Roxo and Telo Faria and K. Mansinho and Jorge Velez and Ramos, {Jos{\'e} Presa} and Hor{\'a}cio Guerreiro and Sara Alberto and Carlos Monteverde and F. Serejo and Paula Peixe and Jos{\'e} Malhado and Manuela Curescu and A. Streinu-Cercel and Florin Caruntu and Hara Livia and Liliana Preotescu and Victoria Arama and Ioan Ancuta and Liana Gheorghe and Carol Stanciu and A. Trifan and Monica Acalovschi and Vasile Andreica and Oliviu Pascu and Monica Lencu and Ioan Sporea and Dan Olteanu and Florentina Ionita-Radu and Carmen Fierbinteanu-Braticevici and Adriana Motoc and Rodica Silaghi and Marioara Musat and Felicia Coman and Marioara Stan and Cristina Cijevschi and Egidia Miftode and Dragan Delic and Rada Jesic and Darko Nozic and Petar Svorcan and Milotka Fabri and Ljiljana Konstantinovic and Mijomir Pelemis and Goran Jankovic and Zoran Todorovic and Aleksandar Nagorni and Viera Kupcova and Lubomir Skladany and Maria Szantova and Dusan Krkoska and Peter Jarcuska and Ivan Schreter and Marian Oltman and Jana Bocakova and Ivan Bunganic and Jozef Holoman and Alain Giguere and Abdou, {Ahmed Mohamed Saleh}",
year = "2016",
month = "3",
day = "1",
doi = "10.1371/journal.pone.0151703",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients

T2 - Results from the GUARD-C Cohort

AU - Foster, Graham

AU - Coppola, Carmine

AU - Derbala, Moutaz

AU - Ferenci, P.

AU - Orlandini, Alessandra

AU - Reddy, K. Rajender

AU - Tallarico, Ludovico

AU - Shiffman, Mitchell L.

AU - Ahlers, Silke

AU - Bakalos, Georgios

AU - Hassanein, Tarek

AU - Basho, Jovan

AU - Shabanaj, Gentian

AU - Harxhi, Arjan

AU - Debzi, Nabil

AU - Afredj, Nawel

AU - Guessab, Nawal

AU - Mahindad, Nadir

AU - Mahiou, Hassene

AU - Aissaoui, Magda

AU - Al Qameesh, Jihad

AU - Al Ghandoor, Zuhal

AU - Assene, Collins

AU - Bastens, Boris

AU - Brixko, Christian

AU - Cool, Mike

AU - De Galocsy, Chantal

AU - Delwaide, J.

AU - George, Christophe

AU - Laukens, Pierre

AU - Lefebvre, Veronique

AU - Mulkay, Jean Pierre

AU - Nevens, Frederik

AU - Servais, Benoit

AU - Van Vlierberghe, H.

AU - Horsmans, Y.

AU - Henrion, Jean

AU - Sprengers, Dirk

AU - Michielsen, P.

AU - Bourgeois, Stefan

AU - Lasser, L.

AU - Langlet, P.

AU - Robaeys, Geert

AU - Martinet, Jean Paul

AU - Warzee, Philippe

AU - Hoste, Paul

AU - Reynaert, Hendrik

AU - Juriens, Irène

AU - Decaestecker, Jochen

AU - Van Der Meersch, Filip

AU - Janssens, Filip

AU - Ahmetagic, Sead

AU - Verhaz, Antonija

AU - Bevanda, Milenko

AU - Calkic, Lejla

AU - Ibrahimpasic, Nevzeta

AU - Mesihovic, Rusmir

AU - Mello, Carlos Eduardo

AU - Ruiz, Fernando Jose

AU - Junior, Elson Martins

AU - Ferraz, Maria Lucia

AU - Silva, Giovanni

AU - Mendes, Claudio

AU - Lyra, Andre

AU - Silva, Mariliza Henrique

AU - Gomide, Geisa

AU - Fernandes, Julio Cesar

AU - Pereira, Patricia

AU - Correa, Maria Cassia

AU - Teixeira, Rosangela

AU - Yousry, Ayman

AU - Hanno, Abdelfatah

AU - Gabr, Mamdouh

AU - Omar, Ashraf

AU - Esmat, G.

AU - Karatapanis, Stilianos

AU - Nikolopoulou, Vassiliki

AU - Giannoulis, Grigoris

AU - Manolakopoulos, Spilios

AU - Elefsiniotis, Ioannis

AU - Drakoulis, Christos

AU - Dimitroulopoulos, Dimitrios

AU - Kanatakis, Stilianos

AU - Ketikoglou, Ioannis

AU - Mimidis, Konstantinos

AU - Evgenidis, Nikolaos

AU - Akriviades, Euaggelos

AU - Vafiadi-Zoubouli, Irini

AU - Tsianos, Epameinondas

AU - Mela, M.

AU - Orfanou, Eleni

AU - Mousoulis, Georgios

AU - Karagiannis, Ioannis

AU - Manesis, Emmanuel

AU - Varga, Marta

AU - Nemesánszky, Elemér

AU - Fried, Katalin

AU - Schuller, János

AU - Szalay, Ferenc

AU - Lengyel, Gabriella

AU - Tornai, Istvan

AU - Bányai, Tivadar

AU - Lesch, Miklos

AU - Nagy, Istvan

AU - Gervain, Judit

AU - Tusnadi, Anna

AU - Schneider, Ferenc

AU - Szentgyörgyi, László

AU - Hunyady, Bela

AU - Vincze, Aron

AU - Tolvaj, Gyula

AU - Varkonyi, Istvan

AU - Makkai, Erzsébet

AU - Enyedi, Judit

AU - Racz, Istvan

AU - Hausinger, Péter

AU - Váczi, Zsuzsanna

AU - Patai, Árpád

AU - Ozsvár, Zsófia

AU - Lakner, Lilla

AU - Ribiczey, Pál

AU - Bhalla, Ajay

AU - Somani, Sanjay

AU - Luaia, Rosang

AU - Rao, Padaki

AU - Philip, Mathew

AU - Lawate, Parimal

AU - Nagral, Aabha

AU - Sood, Ajit

AU - Parikh, Samir

AU - Merat, Shahin

AU - Nassiri-Toosi, Mohsen

AU - Alavian, Seyed Moayed

AU - Zali, M.

AU - Daryani, Nasser Ebrahimi

AU - Drenaggi, D.

AU - Attili, Adolfo F.

AU - Bandiera, Franco

AU - Bassi, Paolo

AU - Bellati, G.

AU - Bellantani, Stefano

AU - Brunetto, M. R.

AU - Bruno, Savino

AU - Castelli, Francesco

AU - Castellacci, Roberto

AU - Cattelan, A.

AU - Colombo, Massimo

AU - Craxi, Antonio

AU - D'angelo, Salvatore

AU - Colombo, Silvia

AU - Demelia, Luigi

AU - Di Perri, Giovanni

AU - Di Giacomo, Antonio

AU - Ferrari, Carlo

AU - Francisci, D.

AU - Casinelli, Katia

AU - Ganga, Roberto

AU - Costa, Chiara

AU - Mangia, Alessandra

AU - Russo, Francesco Paolo

AU - Matarazzo, Filippo

AU - Mazzella, Giuseppe

AU - Mazzeo, Maurizio

AU - Memoli, Massimo

AU - Montalbano, Marzia

AU - Montalto, G.

AU - Pieri, Alessandro

AU - Passariello, Nicola

AU - Picciotto, A.

AU - Pietrangelo, Antonello

AU - Pirisi, Mario

AU - Quirino, T.

AU - Raimondo, G.

AU - Rapaccini, Gianludovico

AU - Rizzardini, G.

AU - Rizzetto, Mario

AU - Russello, M.

AU - Sabusco, G.

AU - Santantonio, Teresa

AU - Soardo, Giorgio

AU - Amedea, Alessandri

AU - Verucchi, G.

AU - Vinelli, Francesco

AU - Zignego, Anna Linda

AU - Zuin, Massimo

AU - Ascione, Antonio

AU - Vinci, Maria

AU - Pigozzi, Maria Graziella

AU - Tundo, Paolo

AU - Saracco, Giorgio

AU - Amoroso, Pietro

AU - Andreoni, M.

AU - Colletta, C.

AU - Erne, Elke

AU - Megna, Angelo Salomone

AU - Biglino, A.

AU - Chiriacò, P. G.

AU - Foti, Giuseppe

AU - Spinzi, Giancarlo

AU - D'amico, Emilio

AU - Paik, Seung Woon

AU - Ahn, Sang Hoon

AU - Lee, Yun Nah

AU - Kim, Yoonjun

AU - Yang, Jinmo

AU - Han, Sang Young

AU - Varghese, Rosh

AU - Al Gharabally, Abeer

AU - Askar, Haifa

AU - Sharara, Ala

AU - Yaghi, Cesar

AU - Abou Rached, Antoine

AU - Houmani, Zaher

AU - Zaarour, Fouad

AU - Dohaibi, Ahmad

AU - Ivanovski, Ljubomir

AU - Joksimovic, Nenad

AU - Abbas, Zaigham

AU - Memon, Sadik

AU - Mohsin, Aftab

AU - Masood, Siddiq

AU - Hashmi, Zahid

AU - Halota, Waldemar

AU - Deron, Zbigniew

AU - Mazur, Wlodzimierz

AU - Flisiak, R.

AU - Lipczynski, Artur

AU - Musialik, Joanna

AU - Piekarska, Anna

AU - Augustyniak, Krystyna

AU - Baka-Cwierz, Barbara

AU - Simon, Krzysztof

AU - Gietka, Andrzej

AU - Berak, Hanna

AU - Sieklucki, Jerzy

AU - Radowska, Danuta

AU - Szlauer, Bronislawa

AU - Piekos, Tomasz

AU - Olszok, Iwona

AU - Jablkowski, Maciej

AU - Orszulak, Grazyna

AU - Warakomska, Iwona

AU - Aleixo, Maria João

AU - Valente, Cristina

AU - Macedo, Guilherme

AU - Sarmento-Castro, Rui

AU - Roxo, Fausto

AU - Faria, Telo

AU - Mansinho, K.

AU - Velez, Jorge

AU - Ramos, José Presa

AU - Guerreiro, Horácio

AU - Alberto, Sara

AU - Monteverde, Carlos

AU - Serejo, F.

AU - Peixe, Paula

AU - Malhado, José

AU - Curescu, Manuela

AU - Streinu-Cercel, A.

AU - Caruntu, Florin

AU - Livia, Hara

AU - Preotescu, Liliana

AU - Arama, Victoria

AU - Ancuta, Ioan

AU - Gheorghe, Liana

AU - Stanciu, Carol

AU - Trifan, A.

AU - Acalovschi, Monica

AU - Andreica, Vasile

AU - Pascu, Oliviu

AU - Lencu, Monica

AU - Sporea, Ioan

AU - Olteanu, Dan

AU - Ionita-Radu, Florentina

AU - Fierbinteanu-Braticevici, Carmen

AU - Motoc, Adriana

AU - Silaghi, Rodica

AU - Musat, Marioara

AU - Coman, Felicia

AU - Stan, Marioara

AU - Cijevschi, Cristina

AU - Miftode, Egidia

AU - Delic, Dragan

AU - Jesic, Rada

AU - Nozic, Darko

AU - Svorcan, Petar

AU - Fabri, Milotka

AU - Konstantinovic, Ljiljana

AU - Pelemis, Mijomir

AU - Jankovic, Goran

AU - Todorovic, Zoran

AU - Nagorni, Aleksandar

AU - Kupcova, Viera

AU - Skladany, Lubomir

AU - Szantova, Maria

AU - Krkoska, Dusan

AU - Jarcuska, Peter

AU - Schreter, Ivan

AU - Oltman, Marian

AU - Bocakova, Jana

AU - Bunganic, Ivan

AU - Holoman, Jozef

AU - Giguere, Alain

AU - Abdou, Ahmed Mohamed Saleh

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

AB - Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

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U2 - 10.1371/journal.pone.0151703

DO - 10.1371/journal.pone.0151703

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e0151703

ER -