Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: An observational study

Matteo Di Nardo, Alessio Ficarella, Zaccaria Ricci, Rosa Luciano, Francesca Stoppa, Sergio Picardo, Stefano Picca, Maurizio Muraca, Paola Cogo

Research output: Contribution to journalArticle


Background/Aims: We hypothesized that sepsis could have an impact on the sensitivity of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) for acute kidney injury (AKI) diagnosis in critically ill children. Methods: Serum NGAL (sNGAL) and urinary NGAL (uNGAL) and CysC were measured daily in the first 48 h from pediatric intensive care unit admission in 11 consecutive critically ill children with severe sepsis; a single measurement was made in a population of 10 healthy controls undergoing minor ambulatory surgery to exclude possible biases in the laboratory methods. Results: uNGAL, serum CysC (sCysC), and urinary CysC (uCysC) levels were significantly increased in patients with septic AKI compared with septic patients without AKI, while sNGAL levels were not significantly different between septic patients with and without AKI. Median serum creatinine levels did not show significant differences between AKI and non-AKI patients. Conclusions: uNGAL, sCysC and uCysC were not altered by sepsis and were good predictors of AKI. In a septic state, sNGAL alone did not discriminate patients with AKI from those without AKI.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalBlood Purification
Issue number1-3
Publication statusPublished - 2013



  • Acute kidney injury
  • Biomarkers
  • Intensive care unit
  • Pediatric critical illness
  • Sepsis

ASJC Scopus subject areas

  • Nephrology
  • Hematology

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