Impact of Statin Therapy on Plasma Uric Acid Concentrations: A Systematic Review and Meta-Analysis

Giuseppe Derosa, Pamela Maffioli, Željko Reiner, Luis E. Simental-Mendía, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review


Purpose: The aim of this study was to ascertain the effect size of statins in modulating plasma uric acid concentrations. Data Sources: A search was undertaken of the MEDLINE, SCOPUS, Web of Science and Google Scholar electronic databases. Study Selection: Studies meeting the following criteria were included: (i) randomized controlled trials with either a parallel or crossover design; (ii) investigated the impact of statin therapy on plasma uric acid concentrations; and (iii) presentation of sufficient information on uric acid values at baseline and at the end of follow-up in each group, or presenting the net change. Data Synthesis: The present meta-analysis suggested a significant reduction in plasma uric acid levels following statin therapy; however, this does not seem to be a class effect as subgroup analysis revealed a significant reduction with atorvastatin and simvastatin only, and not with pravastatin and rosuvastatin. Conclusions: Atorvastatin and simvastatin, but not the other statins, can reduce serum uric acid levels.

Original languageEnglish
Pages (from-to)947-956
Number of pages10
Issue number9
Publication statusPublished - Jun 1 2016

ASJC Scopus subject areas

  • Pharmacology (medical)


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