Abstract
Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p
Original language | English |
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Pages (from-to) | 301-309 |
Number of pages | 9 |
Journal | Cardiovascular Drugs and Therapy |
Volume | 26 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords
- Dyslipidemia
- Haemostasis
- Lipid-Lowering Drugs
- Type 2 Diabetes
ASJC Scopus subject areas
- Pharmacology (medical)
- Cardiology and Cardiovascular Medicine
- Pharmacology