Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

P. Ferroni; D. Della-Morte; A. Pileggi; M. G. Valente; F. Martini; F. La Farina; R. Palmirotta; L. F. Meneghini; T. Rundek; C. Ricordi; F. Guadagni

doi:10.1007/s10557-012-6388-y

Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

P. Ferroni, D. Della-Morte, A. Pileggi, M. G. Valente, F. Martini, F. La Farina, R. Palmirotta, L. F. Meneghini, T. Rundek, C. Ricordi, F. Guadagni

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p

Original language	English
Pages (from-to)	301-309
Number of pages	9
Journal	Cardiovascular Drugs and Therapy
Volume	26
Issue number	4
DOIs	https://doi.org/10.1007/s10557-012-6388-y
Publication status	Published - Aug 2012

Keywords

Dyslipidemia
Haemostasis
Lipid-Lowering Drugs
Type 2 Diabetes

ASJC Scopus subject areas

Pharmacology (medical)
Cardiology and Cardiovascular Medicine
Pharmacology

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Ferroni, P., Della-Morte, D., Pileggi, A., Valente, M. G., Martini, F., La Farina, F., Palmirotta, R., Meneghini, L. F., Rundek, T., Ricordi, C., & Guadagni, F. (2012). Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay. Cardiovascular Drugs and Therapy, 26(4), 301-309. https://doi.org/10.1007/s10557-012-6388-y

Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay. / Ferroni, P.; Della-Morte, D.; Pileggi, A.; Valente, M. G.; Martini, F.; La Farina, F.; Palmirotta, R.; Meneghini, L. F.; Rundek, T.; Ricordi, C.; Guadagni, F.

In: Cardiovascular Drugs and Therapy, Vol. 26, No. 4, 08.2012, p. 301-309.

Research output: Contribution to journal › Article › peer-review

Ferroni, P, Della-Morte, D, Pileggi, A, Valente, MG, Martini, F, La Farina, F, Palmirotta, R, Meneghini, LF, Rundek, T, Ricordi, C & Guadagni, F 2012, 'Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay', Cardiovascular Drugs and Therapy, vol. 26, no. 4, pp. 301-309. https://doi.org/10.1007/s10557-012-6388-y

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AU - Valente, M. G.

AU - Martini, F.

AU - La Farina, F.

AU - Palmirotta, R.

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AU - Ricordi, C.

AU - Guadagni, F.

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AB - Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p

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