TY - JOUR
T1 - Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions
T2 - a RAIN-CARDIOGROUP VII sub-study
AU - Franchin, Luca
AU - Piroli, Francesco
AU - D'Ascenzo, Fabrizio
AU - Nuñez-Gil, Ivan
AU - Wojakowski, Wojciech
AU - Imori, Yoichi
AU - Trabattoni, Daniela
AU - Huczek, Zenon
AU - Venuti, Giuseppe
AU - Muscoli, Saverio
AU - Montabone, Andrea
AU - Rognoni, Andrea
AU - Parma, Radoslaw
AU - Figini, Filippo
AU - Mitomo, Satoru
AU - Quadri, Giorgio
AU - Wańha, Wojciech
AU - Cortese, Bernardo
AU - De Filippo, Ovidio
AU - Ryan, Nicola
AU - Varbella, Ferdinando
AU - Sheiban, Imad
AU - Helft, Gerard
AU - De Ferrari, Gaetano M.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/1/1
Y1 - 2021/1/1
N2 - BACKGROUND: The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population. METHODS: All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87.1% of the lesions involved bifurcations. TLF [defined as a composite of myocardial infarction (MI) and target lesion revascularization (TLR)] was the primary endpoint, with MACE (a composite of death, MI and TLR), its components and stent thrombosis the secondary endpoint. RESULTS: After 16 (14-18) months, a lower incidence of TLF (4.3 vs. 9.8%, P = 0.026) and ST (1.0 vs. 3.0%, P = 0.042) was seen in the 74 μm group, whereas MACE occurred in 60 of 506 patients, with no statistical difference between the two groups (9.7 vs. 13.3%, P = 0.070). At multivariate analysis, chronic renal failure increased the risk of TLF while thinner strut was an independent protective factor (hazard ratio 0.51, CI 0.17-0.85, P = 0.005). CONCLUSION: In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST.
AB - BACKGROUND: The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population. METHODS: All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87.1% of the lesions involved bifurcations. TLF [defined as a composite of myocardial infarction (MI) and target lesion revascularization (TLR)] was the primary endpoint, with MACE (a composite of death, MI and TLR), its components and stent thrombosis the secondary endpoint. RESULTS: After 16 (14-18) months, a lower incidence of TLF (4.3 vs. 9.8%, P = 0.026) and ST (1.0 vs. 3.0%, P = 0.042) was seen in the 74 μm group, whereas MACE occurred in 60 of 506 patients, with no statistical difference between the two groups (9.7 vs. 13.3%, P = 0.070). At multivariate analysis, chronic renal failure increased the risk of TLF while thinner strut was an independent protective factor (hazard ratio 0.51, CI 0.17-0.85, P = 0.005). CONCLUSION: In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST.
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U2 - 10.2459/JCM.0000000000001037
DO - 10.2459/JCM.0000000000001037
M3 - Article
C2 - 32740419
AN - SCOPUS:85097571541
VL - 22
SP - 20
EP - 25
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 1
ER -