Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study

Luca Franchin, Francesco Piroli, Fabrizio D'Ascenzo, Ivan Nuñez-Gil, Wojciech Wojakowski, Yoichi Imori, Daniela Trabattoni, Zenon Huczek, Giuseppe Venuti, Saverio Muscoli, Andrea Montabone, Andrea Rognoni, Radoslaw Parma, Filippo Figini, Satoru Mitomo, Giorgio Quadri, Wojciech Wańha, Bernardo Cortese, Ovidio De Filippo, Nicola RyanFerdinando Varbella, Imad Sheiban, Gerard Helft, Gaetano M. De Ferrari

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population. METHODS: All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87.1% of the lesions involved bifurcations. TLF [defined as a composite of myocardial infarction (MI) and target lesion revascularization (TLR)] was the primary endpoint, with MACE (a composite of death, MI and TLR), its components and stent thrombosis the secondary endpoint. RESULTS: After 16 (14-18) months, a lower incidence of TLF (4.3 vs. 9.8%, P = 0.026) and ST (1.0 vs. 3.0%, P = 0.042) was seen in the 74 μm group, whereas MACE occurred in 60 of 506 patients, with no statistical difference between the two groups (9.7 vs. 13.3%, P = 0.070). At multivariate analysis, chronic renal failure increased the risk of TLF while thinner strut was an independent protective factor (hazard ratio 0.51, CI 0.17-0.85, P = 0.005). CONCLUSION: In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalJournal of cardiovascular medicine (Hagerstown, Md.)
Issue number1
Publication statusPublished - Jan 1 2021

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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