Abstract
Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.
| Original language | English |
|---|---|
| Pages (from-to) | 8-18 |
| Number of pages | 11 |
| Journal | Urologia Internationalis |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 2019 |
Keywords
- Patient-reported outcome measures
- Prostate cancer
- Quality of life
- Radical prostatectomy
- Sexual function
- Urinary function
ASJC Scopus subject areas
- Urology
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Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy : A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study). / Antonelli, Alessandro; Palumbo, Carlotta; Noale, Marianna; Porreca, Angelo; Maggi, Stefania; Simeone, Claudio; Bassi, Pierfrancesco; Bertoni, Filippo; Bracarda, Sergio; Buglione, Michela; Conti, Giario Natale; Corvò, Renzo; Gacci, Mauro; Mirone, Vincenzo; Montironi, Rodolfo; Triggiani, Luca; Tubaro, Andrea; Artibani, Walter; Bartoncini, Sara; Basso, Umberto; Becherini, Carlotta; Bellavita, Rita; Bergamaschi, Franco; Berlingheri, Stefania; Berruti, Alfredo; Borghesi, Marco; Bortolus, Roberto; Borzillo, Valentina; Bosetti, Davide; Bove, Giuseppe; Bove, Pierluigi; Brausi, Maurizio; Bruni, Alessio; Bruno, Giorgio; Brunocilla, Eugenio; Buffoli, Alberto; Buttigliero, Consuelo; Cacciamani, Giovanni; Caldiroli, Michela; Cardo, Giuseppe; Carmignani, Giorgio; Carrieri, Giuseppe; Castelli, Emanuele; Castrezzati, Elisabetta; Catalano, Gianpiero; Cattarino, Susanna; Catucci, Francesco; Cavallini, Francolini Dario; Ceccarini, Ofelia; Celia, Antonio; Chiancone, Francesco; Chini, Tommaso; Cianci, Claudia; Cisternino, Antonio; Collura, Devis; Corbella, Franco; Corinti, Matteo; Corsi, Paolo; Cortese, Fiorenza; Corti, Luigi; de Cosimo, Nunzio; Cristiano, Olga; D'Angelillo, Rolando; Da Pozzo, Luigi; D'agostino, Daniele; D'Elia, Carolina; Dandrea, Matteo; De Angelis, De Michele; De Angelis, Paolo; De Cobelli, Ottavio; De Concilio, Bernardino; De Lisa, Antonello; De Luca, Stefano; De Stefani, Agostina; Deantoni, Chiara Lucrezia; Degli Esposti, Claudio; Destito, Anna; Detti, Beatrice; Di Muzio, Nadia; Di Stasio, Andrea; Di Stefano, Calogero; Di Trapani, Danilo; Difino, Giuseppe; Falivene, Sara; Farullo, Giuseppe; Fedelini, Paolo; Ferrari, Ilaria; Ferraù, Francesco; Ferro, Matteo; Fodor, Andrei; Fontana, Francesco; Francesca, Francesco; Francolini, Giulio; Frata, Paolo; Frezza, Giovanni; Gabriele, Pietro; Galeandro, Maria; Garibaldi, Elisabetta; Gennari Pietro, Giovanni; Gentilucci, Alessandro; Giacobbe, Alessandro; Giussani, Laura; Giusti, Giuseppe; Gontero, Paolo; Guarneri, Alessia; Guida, Cesare; Gurioli, Alberto; Huqi, Dorijan; Imbimbo, Ciro; Ingrosso, Gianluca; Iotti, Cinzia; Italia, Corrado; La Mattina, Pierdaniele; Lamanna, Enza; Lastrucci, Luciana; Lazzari, Grazia; Liberale, Fabiola; Liguori, Giovanni; Lisi, Roberto; Lohr, Frank; Lombardo, Riccardo; Lovisolo, Jon A.J.; Ludovico Giuseppe, Mario; Macchione, Nicola; Maggio, Francesca; Malizia, Michele; Manasse, Gianluca; Mandoliti, Giovanni; Mantini, Giovanna; Marafioti, Luigi; Marciello, Luisa; Marconi Alberto, Mario; Martilotta, Antonietta; Marzano, Salvino; Masciullo, Stefano; Maso, Gloria; Massenzo, Adele; Mazzeo, Ercole; Mearini, Luigi; Medoro, Serena; Molè, Rosa; Monesi, Giorgio; Montanari, Emanuele; Montefiore, Franco; Montesi, Giampaolo; Morgia, Giuseppe; Moro, Gregorio; Muscas, Giorgio; Musio, Daniela; Muto, Paolo; Muzzonigro, Giovanni; Napodano, Giorgio; Negro, Carlo Luigi Augusto; Nidini, Mattia; Ntreta, Maria; Orsatti, Marco; Palazzolo, Carmela; Palumbo, Isabella; Parisi, Alessandro; Parma, Paolo; Pavan, Nicola; Pericolini, Martina; Pinto, Francesco; Pistone, Antonio; Pizzuti, Valerio; Platania, Angelo; Polli, Caterina; Pomara, Giorgio; Ponti, Elisabetta; Porcaro, Antonio Benito; Porpiglia, Francesco; Pugliese, Dario; Pycha, Armin; Raguso, Giuseppe; Rampini, Andrea; Randone Donato, Franco; Roboldi, Valentina; Roscigno, Marco; Ruggieri, Maria Paola; Ruoppo, Giuseppe; Sanseverino, Roberto; Santacaterina, Anna; Santarsieri, Michele; Santoni, Riccardo; Scagliarini, Sarah; Scagliotti Giorgio, Vittorio; Scanzi, Mauro; Scarcia, Marcello; Schiavina, Riccardo; Sciarra, Alessandro; Sciorio, Carmine; Scolaro, Tindaro; Scuzzarella, Salvatore; Selvaggio, Oscar; Serao, Armando; Serni, Sergio; Signor, Marco Andrea; Silvani, Mauro; Silvano, Giovanni; Silvestris, Franco; Simone, Valeria; Spagnoletti, Girolamo; Spinelli Matteo, Giulio; Squillace, Luigi; Tombolini, Vincenzo; Toninelli, Mariastella; Trinchieri, Alberto; Trodella, Luca Eolo; Trodella, Lucio; Trombetta, Carlo; Tronnolone, Lidia; Tucci, Marcello; Urzì, Daniele; Valdagni, Riccardo; Valeriani, Maurizio; Vanoli, Maurizio; Vitali, Elisabetta; Volpe, Alessandro; Zaramella, Stefano; Zeccolini, Guglielmo; Zini, Giampaolo.
In: Urologia Internationalis, Vol. 103, No. 1, 01.07.2019, p. 8-18.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy
T2 - A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)
AU - Antonelli, Alessandro
AU - Palumbo, Carlotta
AU - Noale, Marianna
AU - Porreca, Angelo
AU - Maggi, Stefania
AU - Simeone, Claudio
AU - Bassi, Pierfrancesco
AU - Bertoni, Filippo
AU - Bracarda, Sergio
AU - Buglione, Michela
AU - Conti, Giario Natale
AU - Corvò, Renzo
AU - Gacci, Mauro
AU - Mirone, Vincenzo
AU - Montironi, Rodolfo
AU - Triggiani, Luca
AU - Tubaro, Andrea
AU - Artibani, Walter
AU - Bartoncini, Sara
AU - Basso, Umberto
AU - Becherini, Carlotta
AU - Bellavita, Rita
AU - Bergamaschi, Franco
AU - Berlingheri, Stefania
AU - Berruti, Alfredo
AU - Borghesi, Marco
AU - Bortolus, Roberto
AU - Borzillo, Valentina
AU - Bosetti, Davide
AU - Bove, Giuseppe
AU - Bove, Pierluigi
AU - Brausi, Maurizio
AU - Bruni, Alessio
AU - Bruno, Giorgio
AU - Brunocilla, Eugenio
AU - Buffoli, Alberto
AU - Buttigliero, Consuelo
AU - Cacciamani, Giovanni
AU - Caldiroli, Michela
AU - Cardo, Giuseppe
AU - Carmignani, Giorgio
AU - Carrieri, Giuseppe
AU - Castelli, Emanuele
AU - Castrezzati, Elisabetta
AU - Catalano, Gianpiero
AU - Cattarino, Susanna
AU - Catucci, Francesco
AU - Cavallini, Francolini Dario
AU - Ceccarini, Ofelia
AU - Celia, Antonio
AU - Chiancone, Francesco
AU - Chini, Tommaso
AU - Cianci, Claudia
AU - Cisternino, Antonio
AU - Collura, Devis
AU - Corbella, Franco
AU - Corinti, Matteo
AU - Corsi, Paolo
AU - Cortese, Fiorenza
AU - Corti, Luigi
AU - de Cosimo, Nunzio
AU - Cristiano, Olga
AU - D'Angelillo, Rolando
AU - Da Pozzo, Luigi
AU - D'agostino, Daniele
AU - D'Elia, Carolina
AU - Dandrea, Matteo
AU - De Angelis, De Michele
AU - De Angelis, Paolo
AU - De Cobelli, Ottavio
AU - De Concilio, Bernardino
AU - De Lisa, Antonello
AU - De Luca, Stefano
AU - De Stefani, Agostina
AU - Deantoni, Chiara Lucrezia
AU - Degli Esposti, Claudio
AU - Destito, Anna
AU - Detti, Beatrice
AU - Di Muzio, Nadia
AU - Di Stasio, Andrea
AU - Di Stefano, Calogero
AU - Di Trapani, Danilo
AU - Difino, Giuseppe
AU - Falivene, Sara
AU - Farullo, Giuseppe
AU - Fedelini, Paolo
AU - Ferrari, Ilaria
AU - Ferraù, Francesco
AU - Ferro, Matteo
AU - Fodor, Andrei
AU - Fontana, Francesco
AU - Francesca, Francesco
AU - Francolini, Giulio
AU - Frata, Paolo
AU - Frezza, Giovanni
AU - Gabriele, Pietro
AU - Galeandro, Maria
AU - Garibaldi, Elisabetta
AU - Gennari Pietro, Giovanni
AU - Gentilucci, Alessandro
AU - Giacobbe, Alessandro
AU - Giussani, Laura
AU - Giusti, Giuseppe
AU - Gontero, Paolo
AU - Guarneri, Alessia
AU - Guida, Cesare
AU - Gurioli, Alberto
AU - Huqi, Dorijan
AU - Imbimbo, Ciro
AU - Ingrosso, Gianluca
AU - Iotti, Cinzia
AU - Italia, Corrado
AU - La Mattina, Pierdaniele
AU - Lamanna, Enza
AU - Lastrucci, Luciana
AU - Lazzari, Grazia
AU - Liberale, Fabiola
AU - Liguori, Giovanni
AU - Lisi, Roberto
AU - Lohr, Frank
AU - Lombardo, Riccardo
AU - Lovisolo, Jon A.J.
AU - Ludovico Giuseppe, Mario
AU - Macchione, Nicola
AU - Maggio, Francesca
AU - Malizia, Michele
AU - Manasse, Gianluca
AU - Mandoliti, Giovanni
AU - Mantini, Giovanna
AU - Marafioti, Luigi
AU - Marciello, Luisa
AU - Marconi Alberto, Mario
AU - Martilotta, Antonietta
AU - Marzano, Salvino
AU - Masciullo, Stefano
AU - Maso, Gloria
AU - Massenzo, Adele
AU - Mazzeo, Ercole
AU - Mearini, Luigi
AU - Medoro, Serena
AU - Molè, Rosa
AU - Monesi, Giorgio
AU - Montanari, Emanuele
AU - Montefiore, Franco
AU - Montesi, Giampaolo
AU - Morgia, Giuseppe
AU - Moro, Gregorio
AU - Muscas, Giorgio
AU - Musio, Daniela
AU - Muto, Paolo
AU - Muzzonigro, Giovanni
AU - Napodano, Giorgio
AU - Negro, Carlo Luigi Augusto
AU - Nidini, Mattia
AU - Ntreta, Maria
AU - Orsatti, Marco
AU - Palazzolo, Carmela
AU - Palumbo, Isabella
AU - Parisi, Alessandro
AU - Parma, Paolo
AU - Pavan, Nicola
AU - Pericolini, Martina
AU - Pinto, Francesco
AU - Pistone, Antonio
AU - Pizzuti, Valerio
AU - Platania, Angelo
AU - Polli, Caterina
AU - Pomara, Giorgio
AU - Ponti, Elisabetta
AU - Porcaro, Antonio Benito
AU - Porpiglia, Francesco
AU - Pugliese, Dario
AU - Pycha, Armin
AU - Raguso, Giuseppe
AU - Rampini, Andrea
AU - Randone Donato, Franco
AU - Roboldi, Valentina
AU - Roscigno, Marco
AU - Ruggieri, Maria Paola
AU - Ruoppo, Giuseppe
AU - Sanseverino, Roberto
AU - Santacaterina, Anna
AU - Santarsieri, Michele
AU - Santoni, Riccardo
AU - Scagliarini, Sarah
AU - Scagliotti Giorgio, Vittorio
AU - Scanzi, Mauro
AU - Scarcia, Marcello
AU - Schiavina, Riccardo
AU - Sciarra, Alessandro
AU - Sciorio, Carmine
AU - Scolaro, Tindaro
AU - Scuzzarella, Salvatore
AU - Selvaggio, Oscar
AU - Serao, Armando
AU - Serni, Sergio
AU - Signor, Marco Andrea
AU - Silvani, Mauro
AU - Silvano, Giovanni
AU - Silvestris, Franco
AU - Simone, Valeria
AU - Spagnoletti, Girolamo
AU - Spinelli Matteo, Giulio
AU - Squillace, Luigi
AU - Tombolini, Vincenzo
AU - Toninelli, Mariastella
AU - Trinchieri, Alberto
AU - Trodella, Luca Eolo
AU - Trodella, Lucio
AU - Trombetta, Carlo
AU - Tronnolone, Lidia
AU - Tucci, Marcello
AU - Urzì, Daniele
AU - Valdagni, Riccardo
AU - Valeriani, Maurizio
AU - Vanoli, Maurizio
AU - Vitali, Elisabetta
AU - Volpe, Alessandro
AU - Zaramella, Stefano
AU - Zeccolini, Guglielmo
AU - Zini, Giampaolo
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.
AB - Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.
KW - Patient-reported outcome measures
KW - Prostate cancer
KW - Quality of life
KW - Radical prostatectomy
KW - Sexual function
KW - Urinary function
UR - http://www.scopus.com/inward/record.url?scp=85061307706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061307706&partnerID=8YFLogxK
U2 - 10.1159/000496980
DO - 10.1159/000496980
M3 - Article
C2 - 30731456
AN - SCOPUS:85061307706
VL - 103
SP - 8
EP - 18
JO - Urologia Internationalis
JF - Urologia Internationalis
SN - 0042-1138
IS - 1
ER -