Impact of Surgical Route in Influencing the Risk of Lymphatic Complications After Ovarian Cancer Staging

Giorgio Bogani, Chiara Borghi, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Cono Scaffa, Stefania Perotto, Umberto Leone Roberti Maggiore, Luca Montanelli, Violante Di Donato, Carmelo Infantino, Domenica Lorusso, Francesco Raspagliesi

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Lymphatic complications are a common occurrence after staging surgery for early-stage ovarian cancer (eEOC). We investigated whether the introduction of minimally invasive surgery influences the risk of developing lymphoceles and lymphorrhea in patients undergoing staging for eEOC. For this purpose, data of consecutive patients affected by eEOC undergoing staging surgery between January 1980 and January 2016 were retrospectively reviewed, and a systematic review and meta-analysis was performed. This systematic review was registered in the International Prospective Register of Systematic Review. Among 341 patients included in the present study, 47 severe postoperative complications occurred (13.7%), including 40 lymphatic complications: 31 symptomatic lymphoceles (9%) and 9 cases of lymphorrhea (2.6%), respectively. Laparoscopic staging correlated with a lower risk of developing any severe lymphatic complications in comparison with open surgery (p =.02). In particular, the laparoscopic approach and para-aortic node involvement were associated with a trend toward lower lymphoceles (odds ratio,.13; 95% confidence interval,.07−2.20; p =.05) and a trend toward higher risk of lymphorrhea developing (odds ratio, 4.02; 95% confidence interval,.93−17.3; p =.06), respectively. In conclusion, the implementation of a minimally invasive approach might result in a slight reduction of lymphatic complications after eEOC staging.

Original languageEnglish
Pages (from-to)739-746
Number of pages8
JournalJournal of Minimally Invasive Gynecology
Volume24
Issue number5
DOIs
Publication statusPublished - Jul 1 2017

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Neoplasm Staging
Lymphocele
Ovarian Neoplasms
Odds Ratio
Confidence Intervals
Minimally Invasive Surgical Procedures
Meta-Analysis

Keywords

  • Laparoscopy
  • Lymphoceles
  • Lymphorrhea
  • Ovarian cancer
  • Staging

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Impact of Surgical Route in Influencing the Risk of Lymphatic Complications After Ovarian Cancer Staging. / Bogani, Giorgio; Borghi, Chiara; Ditto, Antonino; Signorelli, Mauro; Martinelli, Fabio; Chiappa, Valentina; Scaffa, Cono; Perotto, Stefania; Leone Roberti Maggiore, Umberto; Montanelli, Luca; Di Donato, Violante; Infantino, Carmelo; Lorusso, Domenica; Raspagliesi, Francesco.

In: Journal of Minimally Invasive Gynecology, Vol. 24, No. 5, 01.07.2017, p. 739-746.

Research output: Contribution to journalReview article

Bogani, Giorgio ; Borghi, Chiara ; Ditto, Antonino ; Signorelli, Mauro ; Martinelli, Fabio ; Chiappa, Valentina ; Scaffa, Cono ; Perotto, Stefania ; Leone Roberti Maggiore, Umberto ; Montanelli, Luca ; Di Donato, Violante ; Infantino, Carmelo ; Lorusso, Domenica ; Raspagliesi, Francesco. / Impact of Surgical Route in Influencing the Risk of Lymphatic Complications After Ovarian Cancer Staging. In: Journal of Minimally Invasive Gynecology. 2017 ; Vol. 24, No. 5. pp. 739-746.
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