TY - JOUR
T1 - Impact of T-cell depletion strategies on outcomes following hematopoietic stem cell transplantation for idiopathic aplastic anemia
T2 - A study on behalf of the European blood and marrow transplant severe aplastic anemia working party
AU - Severe Aplastic Anaemia Working Party of the EBMT
AU - Samarasinghe, Sujith
AU - Clesham, Katherine
AU - Iacobelli, Simona
AU - Sbianchi, Giulia
AU - Knol, Cora
AU - Hamladji, Rose Marie
AU - Socié, Gerard
AU - Aljurf, Mahmoud
AU - Koh, Mickey
AU - Sengeloev, Henrik
AU - Dalle, Jean Hugues
AU - Robinson, Stephen
AU - Van Lint, Maria Teresa
AU - Halkes, Constantijn J.M.
AU - Beelen, Dietrich
AU - Mufti, Ghulam J.
AU - Snowden, John
AU - Blaise, Didier
AU - de Latour, Regis Peffault
AU - Marsh, Judith
AU - Dufour, Carlo
AU - Risitano, Antonio M.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We retrospectively analyzed the outcomes of 1837 adults and children with severe aplastic anemia (SAA) who underwent matched sibling donor (MSD) and matched unrelated donor (MUD) hemopoietic stem cell transplantation (HSCT) between 2000 and 2013. Patients were grouped by transplant conditioning containing either anti-thymocyte globulin (ATG) (n = 1283), alemtuzumab (n = 261), or no serotherapy (NS) (n = 293). The risks of chronic GvHD were significantly reduced when ATG or alemtuzumab were compared with NS (P =.021 and.003, respectively). Acute GVHD was significantly reduced in favor of alemtuzumab compared with ATG (P =.012) and NS (P <.001). By multivariate analysis, when compared with ATG, alemtuzumab was associated with a lower risk of developing acute (OR 0.262; 95% CI 0.14-0.47; P <.001) and chronic GVHD (HR 0.58; 95% CI 0.35-0.94; P =.027). OS was significantly better in ATG and alemtuzumab patients compared with NS (P =.010 and.025). Our data shows inclusion of serotherapy in MSD and MUD HSCT for patients with SAA reduces chronic GVHD and provides a survival advantage over patients not receiving serotherapy. Notably, alemtuzumab reduced the risk of acute and chronic GvHD compared with ATG and indicates that alemtuzumab might be the serotherapy of choice for MSD and MUD transplants for SAA.
AB - We retrospectively analyzed the outcomes of 1837 adults and children with severe aplastic anemia (SAA) who underwent matched sibling donor (MSD) and matched unrelated donor (MUD) hemopoietic stem cell transplantation (HSCT) between 2000 and 2013. Patients were grouped by transplant conditioning containing either anti-thymocyte globulin (ATG) (n = 1283), alemtuzumab (n = 261), or no serotherapy (NS) (n = 293). The risks of chronic GvHD were significantly reduced when ATG or alemtuzumab were compared with NS (P =.021 and.003, respectively). Acute GVHD was significantly reduced in favor of alemtuzumab compared with ATG (P =.012) and NS (P <.001). By multivariate analysis, when compared with ATG, alemtuzumab was associated with a lower risk of developing acute (OR 0.262; 95% CI 0.14-0.47; P <.001) and chronic GVHD (HR 0.58; 95% CI 0.35-0.94; P =.027). OS was significantly better in ATG and alemtuzumab patients compared with NS (P =.010 and.025). Our data shows inclusion of serotherapy in MSD and MUD HSCT for patients with SAA reduces chronic GVHD and provides a survival advantage over patients not receiving serotherapy. Notably, alemtuzumab reduced the risk of acute and chronic GvHD compared with ATG and indicates that alemtuzumab might be the serotherapy of choice for MSD and MUD transplants for SAA.
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U2 - 10.1002/ajh.25314
DO - 10.1002/ajh.25314
M3 - Article
AN - SCOPUS:85057251331
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
ER -