TY - JOUR
T1 - Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based prognostic scoring system (WPSS)
AU - Malcovati, Luca
AU - Porta, Matteo G Della
AU - Strupp, Corinna
AU - Ambaglio, Ilaria
AU - Kuendgen, Andrea
AU - Nachtkamp, Kathrin
AU - Travaglino, Erica
AU - Invernizzi, Rosangela
AU - Pascutto, Cristiana
AU - Lazzarino, Mario
AU - Germing, Ulrich
AU - Cazzola, Mario
PY - 2011/10
Y1 - 2011/10
N2 - Background Anemia is an established negative prognostic factor in myelodysplastic syndromes but the relationship between its degree and clinical outcome is poorly defined. We, therefore, studied the relationship between severity of anemia and outcome in myelodysplastic syndrome patients. Design and Methods We studied 840 consecutive patients diagnosed with myelodysplastic syndromes at the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, and 504 patients seen at the Heinrich- Heine-University Hospital, Düsseldorf, Germany. Hemoglobin levels were monitored longitudinally and analyzed by means of time-dependent Cox's proportional hazards regression models. Results Hemoglobin levels lower than 9 g/dL in males (HR 5.56, P=0.018) and 8 g/dL in females (HR=5.35, P=0.026) were independently related to reduced overall survival, higher risk of nonleukemic death and cardiac death (P
AB - Background Anemia is an established negative prognostic factor in myelodysplastic syndromes but the relationship between its degree and clinical outcome is poorly defined. We, therefore, studied the relationship between severity of anemia and outcome in myelodysplastic syndrome patients. Design and Methods We studied 840 consecutive patients diagnosed with myelodysplastic syndromes at the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, and 504 patients seen at the Heinrich- Heine-University Hospital, Düsseldorf, Germany. Hemoglobin levels were monitored longitudinally and analyzed by means of time-dependent Cox's proportional hazards regression models. Results Hemoglobin levels lower than 9 g/dL in males (HR 5.56, P=0.018) and 8 g/dL in females (HR=5.35, P=0.026) were independently related to reduced overall survival, higher risk of nonleukemic death and cardiac death (P
KW - Anemia
KW - Myelodysplastic syndromes
KW - Outcome
KW - WPSS
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U2 - 10.3324/haematol.2011.044602
DO - 10.3324/haematol.2011.044602
M3 - Article
C2 - 21659359
AN - SCOPUS:80053186861
VL - 96
SP - 1433
EP - 1440
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 10
ER -