Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: A retrospective analysis of the European Society for Blood and Marrow Transplantation-Chronic Malignancies Working Party

Francesco Onida, Ronald Brand, Anja van Biezen, Michel Schaap, Peter A. von dem Borne, Johan Maertens, Dietrich W. Beelen, Enric Carreras, Emilio P. Alessandrino, Liisa Volin, Jürgen H E Kuball, Angela Figuera, Jorge Sierra, Jürgen Finke, Nicolaus Kröger, Theo de Witte

Research output: Contribution to journalArticle

Abstract

Acquired chromosomal abnormalities are important prognostic factors in patients with myelodysplastic syndromes treated with supportive care and with disease-modifying therapeutic interventions, including allogeneic hematopoietic stem cell transplantation. To assess the prognostic impact of cytogenetic characteristics after hematopoietic stem cell transplantation accurately, we investigated a homogeneous group of 523 patients with primary myelodysplastic syndromes who have received stem cells from human leukocyte antigen-identical siblings. Overall survival at five years from transplantation in good, intermediate, and poor cytogenetic risk groups according to the International Prognostic Scoring System was 48%, 45% and 30%, respectively (P

Original languageEnglish
Pages (from-to)1582-1590
Number of pages9
JournalHaematologica
Volume99
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

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