Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases

Cinzia Ferraris, Monica Guglielmetti, Ludovica Pasca, Valentina De Giorgis, Ottavia Eleonora Ferraro, Ilaria Brambilla, Alessandro Leone, Ramona De Amicis, Simona Bertoli, Pierangelo Veggiotti, Anna Tagliabue

Research output: Contribution to journalArticle

Abstract

Data on the impact of the ketogenic diet (KD) on children’s growth remain controversial. Here, we retrospectively investigated the occurrence of linear growth retardation in 34 children (47% males; age range: 2−17 years) diagnosed with drug-resistant epilepsy (DRE; n = 14) or glucose transporter type 1 deficiency syndrome (GLUT1-DS; n = 20) who had been treated with the KD for 12 months. The general characteristics of children with and without growth retardation were also compared. All participants received a full-calorie, traditional KD supplemented with vitamins, minerals, and citrate. Most children (80%; 11/14 in the DRE subgroup and 16/20 in the GLUT1-DS subgroup) treated with the KD did not show growth retardation at 12 months. Although participants with and without delay of growth did not differ in terms of baseline clinical characteristics, dietary prescriptions, or supplementation patterns, marked ketosis at 12 months tended to occur more frequently in the latter group. Altogether, our results indicate that growth retardation may occur in a minority of children treated with the KD. However, further research is required to identify children at risk and to clarify how increased ketones levels may affect endocrine pathways regulating growth during KD administration.
Original languageUndefined/Unknown
JournalNutrients
Volume11
Issue number7
DOIs
Publication statusPublished - 2019

Cite this

Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases. / Ferraris, Cinzia; Guglielmetti, Monica; Pasca, Ludovica; De Giorgis, Valentina; Ferraro, Ottavia Eleonora; Brambilla, Ilaria; Leone, Alessandro; De Amicis, Ramona; Bertoli, Simona; Veggiotti, Pierangelo; Tagliabue, Anna.

In: Nutrients, Vol. 11, No. 7, 2019.

Research output: Contribution to journalArticle

Ferraris, C, Guglielmetti, M, Pasca, L, De Giorgis, V, Ferraro, OE, Brambilla, I, Leone, A, De Amicis, R, Bertoli, S, Veggiotti, P & Tagliabue, A 2019, 'Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases', Nutrients, vol. 11, no. 7. https://doi.org/10.3390/nu11071442
Ferraris, Cinzia ; Guglielmetti, Monica ; Pasca, Ludovica ; De Giorgis, Valentina ; Ferraro, Ottavia Eleonora ; Brambilla, Ilaria ; Leone, Alessandro ; De Amicis, Ramona ; Bertoli, Simona ; Veggiotti, Pierangelo ; Tagliabue, Anna. / Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases. In: Nutrients. 2019 ; Vol. 11, No. 7.
@article{6a46aca9b95c446da23fdcbcf2f1240e,
title = "Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases",
abstract = "Data on the impact of the ketogenic diet (KD) on children’s growth remain controversial. Here, we retrospectively investigated the occurrence of linear growth retardation in 34 children (47{\%} males; age range: 2−17 years) diagnosed with drug-resistant epilepsy (DRE; n = 14) or glucose transporter type 1 deficiency syndrome (GLUT1-DS; n = 20) who had been treated with the KD for 12 months. The general characteristics of children with and without growth retardation were also compared. All participants received a full-calorie, traditional KD supplemented with vitamins, minerals, and citrate. Most children (80{\%}; 11/14 in the DRE subgroup and 16/20 in the GLUT1-DS subgroup) treated with the KD did not show growth retardation at 12 months. Although participants with and without delay of growth did not differ in terms of baseline clinical characteristics, dietary prescriptions, or supplementation patterns, marked ketosis at 12 months tended to occur more frequently in the latter group. Altogether, our results indicate that growth retardation may occur in a minority of children treated with the KD. However, further research is required to identify children at risk and to clarify how increased ketones levels may affect endocrine pathways regulating growth during KD administration.",
author = "Cinzia Ferraris and Monica Guglielmetti and Ludovica Pasca and {De Giorgis}, Valentina and Ferraro, {Ottavia Eleonora} and Ilaria Brambilla and Alessandro Leone and {De Amicis}, Ramona and Simona Bertoli and Pierangelo Veggiotti and Anna Tagliabue",
year = "2019",
doi = "10.3390/nu11071442",
language = "Non definita",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "NLM (Medline)",
number = "7",

}

TY - JOUR

T1 - Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases

AU - Ferraris, Cinzia

AU - Guglielmetti, Monica

AU - Pasca, Ludovica

AU - De Giorgis, Valentina

AU - Ferraro, Ottavia Eleonora

AU - Brambilla, Ilaria

AU - Leone, Alessandro

AU - De Amicis, Ramona

AU - Bertoli, Simona

AU - Veggiotti, Pierangelo

AU - Tagliabue, Anna

PY - 2019

Y1 - 2019

N2 - Data on the impact of the ketogenic diet (KD) on children’s growth remain controversial. Here, we retrospectively investigated the occurrence of linear growth retardation in 34 children (47% males; age range: 2−17 years) diagnosed with drug-resistant epilepsy (DRE; n = 14) or glucose transporter type 1 deficiency syndrome (GLUT1-DS; n = 20) who had been treated with the KD for 12 months. The general characteristics of children with and without growth retardation were also compared. All participants received a full-calorie, traditional KD supplemented with vitamins, minerals, and citrate. Most children (80%; 11/14 in the DRE subgroup and 16/20 in the GLUT1-DS subgroup) treated with the KD did not show growth retardation at 12 months. Although participants with and without delay of growth did not differ in terms of baseline clinical characteristics, dietary prescriptions, or supplementation patterns, marked ketosis at 12 months tended to occur more frequently in the latter group. Altogether, our results indicate that growth retardation may occur in a minority of children treated with the KD. However, further research is required to identify children at risk and to clarify how increased ketones levels may affect endocrine pathways regulating growth during KD administration.

AB - Data on the impact of the ketogenic diet (KD) on children’s growth remain controversial. Here, we retrospectively investigated the occurrence of linear growth retardation in 34 children (47% males; age range: 2−17 years) diagnosed with drug-resistant epilepsy (DRE; n = 14) or glucose transporter type 1 deficiency syndrome (GLUT1-DS; n = 20) who had been treated with the KD for 12 months. The general characteristics of children with and without growth retardation were also compared. All participants received a full-calorie, traditional KD supplemented with vitamins, minerals, and citrate. Most children (80%; 11/14 in the DRE subgroup and 16/20 in the GLUT1-DS subgroup) treated with the KD did not show growth retardation at 12 months. Although participants with and without delay of growth did not differ in terms of baseline clinical characteristics, dietary prescriptions, or supplementation patterns, marked ketosis at 12 months tended to occur more frequently in the latter group. Altogether, our results indicate that growth retardation may occur in a minority of children treated with the KD. However, further research is required to identify children at risk and to clarify how increased ketones levels may affect endocrine pathways regulating growth during KD administration.

U2 - 10.3390/nu11071442

DO - 10.3390/nu11071442

M3 - Articolo

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 7

ER -