Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection

Sabine Kinloch-De Loes, Bruno Hoen, Don E. Smith, Brigitte Autran, Fiona C. Lampe, Andrew N. Phillips, Li Ean Goh, Jan Andersson, Christos Tsoukas, Anders Sonnerborg, Giuseppe Tambussi, Pierre Marie Girard, Mark Bloch, Manuel Battegay, Nick Carter, Raphaelle El Habib, Georgia Theofan, David A. Cooper, Luc Perrin

Research output: Contribution to journalArticle

Abstract

Background. Treatment strategies that would induce durable virological control of human immunodeficiency virus (HIV)-1 in the absence of continued antiretroviral therapy (ART) are highly desirable. Methods. We assessed, in a randomized, double-blind, placebo-controlled trial, whether the addition of therapeutic vaccines (ALVAC-HIV [vCP1452] or ALVAC-HIV and Remune) to ART initiated during acute infection could increase the probability of having a plasma viral load ≤1000 HIV-1 RNA copies/mL 24 weeks after planned discontinuation of ART. Results. All 79 randomized subjects completed the immunization schedule, and 78 discontinued ART with no major safety concerns. After immunization, subjects in the vaccine study arms had significantly increased HIV-1-specific CD4+ and CD8+ T cell responses, by interferon-γ enzyme-linked immunospot assay, compared with those in the placebo study arm. Overall, 17.7% of subjects had ≤1000 HIV-1 RNA copies/mL 24 weeks after discontinuation of ART, with no significant difference between the vaccine study arms and the placebo study arm (15.4% vs. 22.2%; difference, -6.8% [95% confidence interval, -26.8% to 10.0%]; P = .54). Conclusion. Therapeutic immunization and ART, compared with ART alone, generated HIV-1-specific cellular immunity but did not lead to better virological control of HIV-1 24 weeks after discontinuation of ART. Our trial design appears to be feasible and safe for testing future immune-boosting strategies.

Original languageEnglish
Pages (from-to)607-617
Number of pages11
JournalJournal of Infectious Diseases
Volume192
Issue number4
DOIs
Publication statusPublished - Aug 15 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Kinloch-De Loes, S., Hoen, B., Smith, D. E., Autran, B., Lampe, F. C., Phillips, A. N., Goh, L. E., Andersson, J., Tsoukas, C., Sonnerborg, A., Tambussi, G., Girard, P. M., Bloch, M., Battegay, M., Carter, N., El Habib, R., Theofan, G., Cooper, D. A., & Perrin, L. (2005). Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Journal of Infectious Diseases, 192(4), 607-617. https://doi.org/10.1086/432002