Impact of thymopentin on the incidence and severity of postoperative infection: A randomized controlled trial

M. Braga, E. Costantini, A. Di Francesco, L. Gianotti, P. Baccari, V. Di Carlo

Research output: Contribution to journalArticlepeer-review

Abstract

The effectiveness of perioperative administration of thymopentin in preventing postoperative infection was evaluated in 206 patients with cancer (54 gastric, 152 colorectal) who underwent elective major surgery. Comparable subsets of patients were obtained with respect to age (proportion over 65 years) and nutritional status (patients with serum albumin level less than 30 g/l or weight loss of 10 per cent or more of usual body-weight were considered to be malnourished). Patients were then randomly assigned to a control group or to a group receiving thymopentin. All patients received perioperative short-term antibiotic prophylaxis and postoperative parenteral nutrition. Levels of CD3-, CD4- and CD8-positive T cell subsets were evaluated before and after surgery in 20 (ten elderly) patients from each group. The severity of postoperative infection was evaluated using a sepsis score. In elderly patients thymopentin prevented the postoperative drop in CD3- and CD4-positive T cell subpopulations that was observed in controls (P

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalBritish Journal of Surgery
Volume81
Issue number2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Surgery

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