Impact of total body irradiation- vs chemotherapy-based myeloablative conditioning on outcomes of haploidentical hematopoietic cell transplantation for acute myelogenous leukemia

B. Dholaria, M. Labopin, E. Angelucci, F. Ciceri, J.L. Diez-Martin, B. Bruno, S. Sica, Y. Koc, Z. Gülbas, C. Schmid, D. Blaise, A.M. Carella, G. Visani, B.N. Savani, A. Nagler, M. Mohty

Research output: Contribution to journalArticlepeer-review

Abstract

The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation (haplo-HCT) is unknown. We studied the outcomes of total body irradiation (TBI) vs chemotherapy (CT) based MAC regimens in acute myeloid leukemia (AML) patients. The study included 1008 patients who underwent first haplo-HCT with post-transplant cyclophosphamide, following TBI (N = 89, 9%) or CT (n = 919, 91%) based MAC. Patients in the TBI cohort were younger (median age, 38 vs 47 years, P
Original languageEnglish
JournalAm. J. Hematol.
DOIs
Publication statusPublished - 2020

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