Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials

Paolo Bossi, Rosalba Miceli, Marco Benasso, Renzo Corvò, Andrea Bacigalupo, Giuseppe Sanguineti, Carlo Fallai, Marlo C. Merlano, Gabriele Infante, Carla Dani, Valerio Di Giannantonio, Lisa Licitra

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P <.0001) and in OS (HR 0.70, 0.60-0.81, P <.0001) for centers with a higher number of patients recruited. A similar benefit was observed in PFS (HR 0.63, 0.60-0.66) and OS (HR 0.74, 0.69-0.79) considering the mean number of patients per year. Conclusions: The PFS and OS were longer for patients treated in high-case-volume centers.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Head and Neck Neoplasms
Disease-Free Survival
Survival
Therapeutics
Italy
Radiotherapy

Keywords

  • HNCC
  • referral centers
  • survival
  • treatment expertise

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials. / Bossi, Paolo; Miceli, Rosalba; Benasso, Marco; Corvò, Renzo; Bacigalupo, Andrea; Sanguineti, Giuseppe; Fallai, Carlo; Merlano, Marlo C.; Infante, Gabriele; Dani, Carla; Di Giannantonio, Valerio; Licitra, Lisa.

In: Head and Neck, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Bossi, Paolo

AU - Miceli, Rosalba

AU - Benasso, Marco

AU - Corvò, Renzo

AU - Bacigalupo, Andrea

AU - Sanguineti, Giuseppe

AU - Fallai, Carlo

AU - Merlano, Marlo C.

AU - Infante, Gabriele

AU - Dani, Carla

AU - Di Giannantonio, Valerio

AU - Licitra, Lisa

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N2 - Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P <.0001) and in OS (HR 0.70, 0.60-0.81, P <.0001) for centers with a higher number of patients recruited. A similar benefit was observed in PFS (HR 0.63, 0.60-0.66) and OS (HR 0.74, 0.69-0.79) considering the mean number of patients per year. Conclusions: The PFS and OS were longer for patients treated in high-case-volume centers.

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