Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials

Paolo Bossi, Rosalba Miceli, Marco Benasso, Renzo Corvò, Andrea Bacigalupo, Giuseppe Sanguineti, Carlo Fallai, Marlo C. Merlano, Gabriele Infante, Carla Dani, Valerio Di Giannantonio, Lisa Licitra

Research output: Contribution to journalArticle

Abstract

Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P
Original languageEnglish
Pages (from-to)2648-2656
JournalHead and Neck Surgery
Volume40
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

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Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials. / Bossi, Paolo; Miceli, Rosalba; Benasso, Marco; Corvò, Renzo; Bacigalupo, Andrea; Sanguineti, Giuseppe; Fallai, Carlo; Merlano, Marlo C.; Infante, Gabriele; Dani, Carla; Di Giannantonio, Valerio; Licitra, Lisa.

In: Head and Neck Surgery, Vol. 40, No. 12, 01.01.2018, p. 2648-2656.

Research output: Contribution to journalArticle

Bossi, P, Miceli, R, Benasso, M, Corvò, R, Bacigalupo, A, Sanguineti, G, Fallai, C, Merlano, MC, Infante, G, Dani, C, Di Giannantonio, V & Licitra, L 2018, 'Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials', Head and Neck Surgery, vol. 40, no. 12, pp. 2648-2656. https://doi.org/10.1002/hed.25389
Bossi, Paolo ; Miceli, Rosalba ; Benasso, Marco ; Corvò, Renzo ; Bacigalupo, Andrea ; Sanguineti, Giuseppe ; Fallai, Carlo ; Merlano, Marlo C. ; Infante, Gabriele ; Dani, Carla ; Di Giannantonio, Valerio ; Licitra, Lisa. / Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials. In: Head and Neck Surgery. 2018 ; Vol. 40, No. 12. pp. 2648-2656.
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AU - Bossi, Paolo

AU - Miceli, Rosalba

AU - Benasso, Marco

AU - Corvò, Renzo

AU - Bacigalupo, Andrea

AU - Sanguineti, Giuseppe

AU - Fallai, Carlo

AU - Merlano, Marlo C.

AU - Infante, Gabriele

AU - Dani, Carla

AU - Di Giannantonio, Valerio

AU - Licitra, Lisa

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N2 - Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P

AB - Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P

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