Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials

Paolo Bossi, Rosalba Miceli, Marco Benasso, Renzo Corvò, Andrea Bacigalupo, Giuseppe Sanguineti, Carlo Fallai, Marlo C. Merlano, Gabriele Infante, Carla Dani, Valerio Di Giannantonio, Lisa Licitra

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Abstract

Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P
Original languageEnglish
Pages (from-to)2648-2656
JournalHead and Neck Surgery
Volume40
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

Cite this

Bossi, P., Miceli, R., Benasso, M., Corvò, R., Bacigalupo, A., Sanguineti, G., Fallai, C., Merlano, M. C., Infante, G., Dani, C., Di Giannantonio, V., & Licitra, L. (2018). Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials. Head and Neck Surgery, 40(12), 2648-2656. https://doi.org/10.1002/hed.25389