Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection

Silvia Guglietta, Anna Rosa Garbuglia, Leonidas Salichos, Lionello Ruggeri, Antonella Folgori, Maria Paola Perrone, Cristina Camperio, Vincenzo Mellace, Giuseppe Maio, Patrizia Maio, Maria Rosaria Capobianchi, Enea Spada, Nicola Gargano, Cristiano Scottà, Enza Piccolella, Paola Del Porto

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of HCV to mutate in response to cytotoxic T lymphocyte (CTL) pressure is increasingly recognized, but the influence of such a mechanism in viral persistence and final disease outcome has not been ascertained. In this study, we performed a detailed longitudinal analysis of cell mediated immunity and HCV evolution in two self limiting and two chronically evolving HCV acutely infected patients, one of whom transiently controlled viremia. Aminoacid mutations in immunodominant regions of viruses were observed in all patients, although they conferred viral escape from CTL responses only in chronically infected individuals. Resurgence of viremia coincided with the replacement of the original virus quasispecies with mutant viruses that had escaped recognition by primary CD8+ T cell responses and infection persisted in the presence of variant viruses which were less efficiently recognized by preexisting and de novo induced T cell responses.

Original languageEnglish
Pages (from-to)398-406
Number of pages9
JournalVirology
Volume386
Issue number2
DOIs
Publication statusPublished - Apr 10 2009

Keywords

  • Acute infection
  • CD8 T lymphocytes
  • HCV
  • Viral escape

ASJC Scopus subject areas

  • Virology

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