Renal failure is characterized by impairment in autonomic cardiovascular control, with reduced baroreceptor heart-rate modulation and altered cardiopulmonary reflex control of sympathetic vasoconstrictor tone. The autonomic abnormalities also include chemoreflex activation and muscle metaboreceptor reflex dysfunction. These reflex changes contribute to disease progression by promoting and aggravating the adrenergic overdrive seen in patients with renal failure. The adverse cardiovascular effects of this autonomic impairment make autonomic dysfunction a target for the therapeutic approach to renal failure.
- Arterial baroreflex
- Cardiopulmonary reflex
- Parasympathetic nervous system activity
- Reflex cardiovascular control
- Sympathetic nervous system activity
ASJC Scopus subject areas