Impaired autonomic blood pressure and blood volume control in chronic renal failure

Guido Grassi, Raffaella Dell'Oro, Fosca Quarti-Trevano, Giuseppe Mancia

Research output: Chapter in Book/Report/Conference proceedingChapter


Renal failure is characterized by impairment in autonomic cardiovascular control, with reduced baroreceptor heart-rate modulation and altered cardiopulmonary reflex control of sympathetic vasoconstrictor tone. The autonomic abnormalities also include chemoreflex activation and muscle metaboreceptor reflex dysfunction. These reflex changes contribute to disease progression by promoting and aggravating the adrenergic overdrive seen in patients with renal failure. The adverse cardiovascular effects of this autonomic impairment make autonomic dysfunction a target for the therapeutic approach to renal failure.

Original languageEnglish
Title of host publicationCardiorenal Syndrome: Mechanisms, Risk and Treatment
PublisherSpringer Milan
Number of pages7
ISBN (Print)9788847014626
Publication statusPublished - 2010


  • Arterial baroreflex
  • Cardiopulmonary reflex
  • Chemoreflex
  • Parasympathetic nervous system activity
  • Reflex cardiovascular control
  • Sympathetic nervous system activity

ASJC Scopus subject areas

  • Medicine(all)


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