Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure

Paola Lanfranchi, Alberto Braghiroli, Roberto Colombo, Giorgio Mazzuero, Pantaleo Giannuzzi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nocturnal Periodic Breathing is a common finding in severe Chronic Heart Failure (CHF). Patients (pts) with left ventricular dysfunction can exhibit impairment of baroreflex sensitivity (BRS) or heart rate variability (HRV). We studied 48 pts aged 57±8 years with CHF in stable phase (EF=23±6%). All pts underwent a sleep study to assess the occurrence of periodic breathing, and a phenylephrine test to evaluate BRS; 36 patients had also a 24 hour ambulatory electrocardiogram recording to measure HRV. Nocturnal Periodic Breathing was recorded in 75% of patients, BRS was markedly depressed in 60% of patients. HRV was reduced in 58% of patients. Significant correlations were found between %PB and left ventricle EF (p=0.016), BRS (p=0.0002), HRV (p=0.0001), and nocturnal oxygen desaturation (p=0.0001). Nocturnal Periodic Breathing is frequently associated with abnormal autonomic control of cardiac function in patients suffering from chronic heart failure.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherIEEE
Pages309-311
Number of pages3
Publication statusPublished - 1995
EventProceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria
Duration: Sep 10 1995Sep 13 1995

Other

OtherProceedings of the 1995 Conference on Computers in Cardiology
CityVienna, Austria
Period9/10/959/13/95

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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    Lanfranchi, P., Braghiroli, A., Colombo, R., Mazzuero, G., & Giannuzzi, P. (1995). Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure. In Computers in Cardiology (pp. 309-311). IEEE.