Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure

Paola Lanfranchi; Alberto Braghiroli; Roberto Colombo; Giorgio Mazzuero; Pantaleo Giannuzzi

Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure

Paola Lanfranchi, Alberto Braghiroli, Roberto Colombo, Giorgio Mazzuero, Pantaleo Giannuzzi

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Nocturnal Periodic Breathing is a common finding in severe Chronic Heart Failure (CHF). Patients (pts) with left ventricular dysfunction can exhibit impairment of baroreflex sensitivity (BRS) or heart rate variability (HRV). We studied 48 pts aged 57±8 years with CHF in stable phase (EF=23±6%). All pts underwent a sleep study to assess the occurrence of periodic breathing, and a phenylephrine test to evaluate BRS; 36 patients had also a 24 hour ambulatory electrocardiogram recording to measure HRV. Nocturnal Periodic Breathing was recorded in 75% of patients, BRS was markedly depressed in 60% of patients. HRV was reduced in 58% of patients. Significant correlations were found between %PB and left ventricle EF (p=0.016), BRS (p=0.0002), HRV (p=0.0001), and nocturnal oxygen desaturation (p=0.0001). Nocturnal Periodic Breathing is frequently associated with abnormal autonomic control of cardiac function in patients suffering from chronic heart failure.

Original language	English
Title of host publication	Computers in Cardiology
Publisher	IEEE
Pages	309-311
Number of pages	3
Publication status	Published - 1995
Event	Proceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria Duration: Sep 10 1995 → Sep 13 1995

Other

Other	Proceedings of the 1995 Conference on Computers in Cardiology
City	Vienna, Austria
Period	9/10/95 → 9/13/95

ASJC Scopus subject areas

Software
Cardiology and Cardiovascular Medicine

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Lanfranchi, P., Braghiroli, A., Colombo, R., Mazzuero, G., & Giannuzzi, P. (1995). Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure. In Computers in Cardiology (pp. 309-311). IEEE.

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title = "Impaired baroreflex sensitivity and nocturnal periodic breathing in patients with chronic heart failure",

abstract = "Nocturnal Periodic Breathing is a common finding in severe Chronic Heart Failure (CHF). Patients (pts) with left ventricular dysfunction can exhibit impairment of baroreflex sensitivity (BRS) or heart rate variability (HRV). We studied 48 pts aged 57±8 years with CHF in stable phase (EF=23±6%). All pts underwent a sleep study to assess the occurrence of periodic breathing, and a phenylephrine test to evaluate BRS; 36 patients had also a 24 hour ambulatory electrocardiogram recording to measure HRV. Nocturnal Periodic Breathing was recorded in 75% of patients, BRS was markedly depressed in 60% of patients. HRV was reduced in 58% of patients. Significant correlations were found between %PB and left ventricle EF (p=0.016), BRS (p=0.0002), HRV (p=0.0001), and nocturnal oxygen desaturation (p=0.0001). Nocturnal Periodic Breathing is frequently associated with abnormal autonomic control of cardiac function in patients suffering from chronic heart failure.",

author = "Paola Lanfranchi and Alberto Braghiroli and Roberto Colombo and Giorgio Mazzuero and Pantaleo Giannuzzi",

year = "1995",

language = "English",

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AU - Lanfranchi, Paola

AU - Braghiroli, Alberto

AU - Colombo, Roberto

AU - Mazzuero, Giorgio

AU - Giannuzzi, Pantaleo

PY - 1995

Y1 - 1995

N2 - Nocturnal Periodic Breathing is a common finding in severe Chronic Heart Failure (CHF). Patients (pts) with left ventricular dysfunction can exhibit impairment of baroreflex sensitivity (BRS) or heart rate variability (HRV). We studied 48 pts aged 57±8 years with CHF in stable phase (EF=23±6%). All pts underwent a sleep study to assess the occurrence of periodic breathing, and a phenylephrine test to evaluate BRS; 36 patients had also a 24 hour ambulatory electrocardiogram recording to measure HRV. Nocturnal Periodic Breathing was recorded in 75% of patients, BRS was markedly depressed in 60% of patients. HRV was reduced in 58% of patients. Significant correlations were found between %PB and left ventricle EF (p=0.016), BRS (p=0.0002), HRV (p=0.0001), and nocturnal oxygen desaturation (p=0.0001). Nocturnal Periodic Breathing is frequently associated with abnormal autonomic control of cardiac function in patients suffering from chronic heart failure.

AB - Nocturnal Periodic Breathing is a common finding in severe Chronic Heart Failure (CHF). Patients (pts) with left ventricular dysfunction can exhibit impairment of baroreflex sensitivity (BRS) or heart rate variability (HRV). We studied 48 pts aged 57±8 years with CHF in stable phase (EF=23±6%). All pts underwent a sleep study to assess the occurrence of periodic breathing, and a phenylephrine test to evaluate BRS; 36 patients had also a 24 hour ambulatory electrocardiogram recording to measure HRV. Nocturnal Periodic Breathing was recorded in 75% of patients, BRS was markedly depressed in 60% of patients. HRV was reduced in 58% of patients. Significant correlations were found between %PB and left ventricle EF (p=0.016), BRS (p=0.0002), HRV (p=0.0001), and nocturnal oxygen desaturation (p=0.0001). Nocturnal Periodic Breathing is frequently associated with abnormal autonomic control of cardiac function in patients suffering from chronic heart failure.

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