Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice

Christopher Pittenger, Stefania Fasano, David Mazzocchi-Jones, Stephen B. Dunnett, Eric R. Kandel, Riccardo Brambilla

Research output: Contribution to journalArticle

Abstract

The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood.Weexamined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.

Original languageEnglish
Pages (from-to)2808-2813
Number of pages6
JournalJournal of Neuroscience
Volume26
Issue number10
DOIs
Publication statusPublished - Mar 8 2006

Keywords

  • Genetics
  • Learning and memory
  • Memory formation
  • Striatum
  • Synaptic plasticity
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)

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