TY - JOUR
T1 - Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice
AU - Pittenger, Christopher
AU - Fasano, Stefania
AU - Mazzocchi-Jones, David
AU - Dunnett, Stephen B.
AU - Kandel, Eric R.
AU - Brambilla, Riccardo
PY - 2006/3/8
Y1 - 2006/3/8
N2 - The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood.Weexamined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.
AB - The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood.Weexamined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.
KW - Genetics
KW - Learning and memory
KW - Memory formation
KW - Striatum
KW - Synaptic plasticity
KW - Transgenic
UR - http://www.scopus.com/inward/record.url?scp=33644820980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644820980&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.5406-05.2006
DO - 10.1523/JNEUROSCI.5406-05.2006
M3 - Article
C2 - 16525060
AN - SCOPUS:33644820980
VL - 26
SP - 2808
EP - 2813
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 10
ER -