Abstract
The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.
Original language | English |
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Pages (from-to) | 670-672 |
Number of pages | 3 |
Journal | Journal of Clinical Pharmacology |
Volume | 29 |
Issue number | 7 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)