Impaired bioavailability of famotidine given concurrently with a potent antacid

N. Barzaghi, G. Gatti, F. Crema, E. Perucca

Research output: Contribution to journalArticlepeer-review


The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.

Original languageEnglish
Pages (from-to)670-672
Number of pages3
JournalJournal of Clinical Pharmacology
Issue number7
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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