Impaired bioavailability of famotidine given concurrently with a potent antacid

N. Barzaghi; G. Gatti; F. Crema; E. Perucca

Impaired bioavailability of famotidine given concurrently with a potent antacid

N. Barzaghi, G. Gatti, F. Crema, E. Perucca

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.

Original language	English
Pages (from-to)	670-672
Number of pages	3
Journal	Journal of Clinical Pharmacology
Volume	29
Issue number	7
Publication status	Published - 1989

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Impaired bioavailability of famotidine given concurrently with a potent antacid",

abstract = "The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.",

author = "N. Barzaghi and G. Gatti and F. Crema and E. Perucca",

year = "1989",

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journal = "Journal of Clinical Pharmacology",

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T1 - Impaired bioavailability of famotidine given concurrently with a potent antacid

AU - Barzaghi, N.

AU - Gatti, G.

AU - Crema, F.

AU - Perucca, E.

PY - 1989

Y1 - 1989

N2 - The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.

AB - The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross-over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P <0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P <0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.

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