Impaired brachial artery endothelial flow-mediated dilation and orthostatic stress in hemodialysis patients

Maurizio Gallieni, A. Butti, M. Guazzi, A. Galassi, M. Cozzolino, D. Brancaccio

Research output: Contribution to journalArticle

Abstract

Purpose: Chronic kidney disease (CKD) is associated with an impaired endothelial function, which may contribute to cardiovascular events. Whether impairment in endothelial function is involved in the circulatory response to orthostatic stress is unknown. We assessed endothelial function via brachial artery flow-mediated dilation (BAFMD), an index of endothelial-dependent vasodilation. Methods: We measured changes in brachial artery diameter (BAD) and blood flow by Doppler ultrasound in 35 CKD patients on hemodialysis, 37 young healthy controls (HC) and 50 non-uremic matched controls (MC), in the supine position and after 60° head-up tilting (HUT). Results: In the supine position, endothelial flow-mediated BAD was significantly increased in HC (p

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalInternational Journal of Artificial Organs
Volume31
Issue number1
Publication statusPublished - Jan 2008

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Brachial Artery
Renal Dialysis
Dilatation
Supine Position
Chronic Renal Insufficiency
Doppler Ultrasonography
Vasodilation
Blood
Ultrasonics
Head

Keywords

  • Chronic kidney disease
  • Endothelial dysfunction
  • Hypertension
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Biophysics

Cite this

Impaired brachial artery endothelial flow-mediated dilation and orthostatic stress in hemodialysis patients. / Gallieni, Maurizio; Butti, A.; Guazzi, M.; Galassi, A.; Cozzolino, M.; Brancaccio, D.

In: International Journal of Artificial Organs, Vol. 31, No. 1, 01.2008, p. 34-42.

Research output: Contribution to journalArticle

Gallieni, Maurizio ; Butti, A. ; Guazzi, M. ; Galassi, A. ; Cozzolino, M. ; Brancaccio, D. / Impaired brachial artery endothelial flow-mediated dilation and orthostatic stress in hemodialysis patients. In: International Journal of Artificial Organs. 2008 ; Vol. 31, No. 1. pp. 34-42.
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