Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution

Marco Fiore, Anthony A. Grace, Jakob Korf, Barbara Stampachiacchiere, Luigi Aloe

Research output: Contribution to journalArticlepeer-review

Abstract

Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)1791-1795
Number of pages5
JournalNeuroReport
Volume15
Issue number11
DOIs
Publication statusPublished - Aug 6 2004

Keywords

  • BDNF
  • MAM
  • NGF
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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