Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution

Marco Fiore, Anthony A. Grace, Jakob Korf, Barbara Stampachiacchiere, Luigi Aloe

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)1791-1795
Number of pages5
JournalNeuroReport
Volume15
Issue number11
DOIs
Publication statusPublished - Aug 6 2004

Fingerprint

Methylazoxymethanol Acetate
Nerve Growth Factors
Brain-Derived Neurotrophic Factor
Neurotoxins
Nerve Growth Factor
Brain
Entorhinal Cortex
Parietal Lobe
Psychopathology
Young Adult
Hippocampus
Schizophrenia
Acetates

Keywords

  • BDNF
  • MAM
  • NGF
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution. / Fiore, Marco; Grace, Anthony A.; Korf, Jakob; Stampachiacchiere, Barbara; Aloe, Luigi.

In: NeuroReport, Vol. 15, No. 11, 06.08.2004, p. 1791-1795.

Research output: Contribution to journalArticle

Fiore, Marco ; Grace, Anthony A. ; Korf, Jakob ; Stampachiacchiere, Barbara ; Aloe, Luigi. / Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution. In: NeuroReport. 2004 ; Vol. 15, No. 11. pp. 1791-1795.
@article{95ba7797a2184cc690812aad75e7112b,
title = "Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution",
abstract = "Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.",
keywords = "BDNF, MAM, NGF, Schizophrenia",
author = "Marco Fiore and Grace, {Anthony A.} and Jakob Korf and Barbara Stampachiacchiere and Luigi Aloe",
year = "2004",
month = "8",
day = "6",
doi = "10.1097/01.wnr.0000135934.03635.6a",
language = "English",
volume = "15",
pages = "1791--1795",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution

AU - Fiore, Marco

AU - Grace, Anthony A.

AU - Korf, Jakob

AU - Stampachiacchiere, Barbara

AU - Aloe, Luigi

PY - 2004/8/6

Y1 - 2004/8/6

N2 - Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.

AB - Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.

KW - BDNF

KW - MAM

KW - NGF

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=4043070802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043070802&partnerID=8YFLogxK

U2 - 10.1097/01.wnr.0000135934.03635.6a

DO - 10.1097/01.wnr.0000135934.03635.6a

M3 - Article

C2 - 15257149

AN - SCOPUS:4043070802

VL - 15

SP - 1791

EP - 1795

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 11

ER -