Impaired circadian modulation of sympathovagal activity in diabetes: A possible explanation for altered temporal onset of cardiovascular disease

L. Bernardi, L. Ricordi, P. Lazzari, P. Solda, A. Calciati, M. R. Ferrari, I. Vandea, G. Finardi, P. Fratino

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. Methods and Results. To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR interval fluctuations in 54 diabetic subjects (age, 44±2 years) with either normal autonomic function or mild to severe autonomic neuropathy and in 54 age-matched control subjects. The power in the low-frequency (LF, 0.03-0.15 Hz) and high-frequency (HF, 0.18-0.40 Hz) bands was considered an index of relative sympathetic and vagal activity, respectively. Diabetic subjects with autonomic abnormalities showed a reduction in LF compared with control subjects (5.95±0.12 ln-msec 2 versus 6.73±0.11, p2 versus 6.52±0.14, p

Original languageEnglish
Pages (from-to)1443-1452
Number of pages10
JournalCirculation
Volume86
Issue number5
Publication statusPublished - 1992

Keywords

  • autonomic neuropathy
  • diabetes mellitus
  • heart rate variability
  • Holter recordings
  • power spectrum analysis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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