TY - JOUR
T1 - Impaired circadian modulation of sympathovagal activity in diabetes
T2 - A possible explanation for altered temporal onset of cardiovascular disease
AU - Bernardi, L.
AU - Ricordi, L.
AU - Lazzari, P.
AU - Solda, P.
AU - Calciati, A.
AU - Ferrari, M. R.
AU - Vandea, I.
AU - Finardi, G.
AU - Fratino, P.
PY - 1992
Y1 - 1992
N2 - Background. Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. Methods and Results. To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR interval fluctuations in 54 diabetic subjects (age, 44±2 years) with either normal autonomic function or mild to severe autonomic neuropathy and in 54 age-matched control subjects. The power in the low-frequency (LF, 0.03-0.15 Hz) and high-frequency (HF, 0.18-0.40 Hz) bands was considered an index of relative sympathetic and vagal activity, respectively. Diabetic subjects with autonomic abnormalities showed a reduction in LF compared with control subjects (5.95±0.12 ln-msec
2 versus 6.73±0.11, p2 versus 6.52±0.14, p
AB - Background. Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. Methods and Results. To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR interval fluctuations in 54 diabetic subjects (age, 44±2 years) with either normal autonomic function or mild to severe autonomic neuropathy and in 54 age-matched control subjects. The power in the low-frequency (LF, 0.03-0.15 Hz) and high-frequency (HF, 0.18-0.40 Hz) bands was considered an index of relative sympathetic and vagal activity, respectively. Diabetic subjects with autonomic abnormalities showed a reduction in LF compared with control subjects (5.95±0.12 ln-msec
2 versus 6.73±0.11, p2 versus 6.52±0.14, p
KW - autonomic neuropathy
KW - diabetes mellitus
KW - heart rate variability
KW - Holter recordings
KW - power spectrum analysis
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M3 - Article
C2 - 1423958
AN - SCOPUS:0026466158
VL - 86
SP - 1443
EP - 1452
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 5
ER -