Impaired control of vasopressin release in hypertensive subjects with cardiac hypertrophy

B. Trimarco, N. De Luca, A. De Simone, M. Volpe, B. Ricciardelli, G. Lembo, M. Condorelli

Research output: Contribution to journalArticle

Abstract

The effects of graded lower body negative pressure (-10 and -40 mm Hg) on vascular resistance and plasma vasopressin, norepinephrine, and renin activity were assessed in seven hypertensive subjects with left ventricular hypertrophy and seven sex-matched and age-matched normotensive subjects. In both groups increasing levels of lower body negative pressure induced a progressive decrease in right atrial pressure and an increase in vascular resistance. In normal subjects plasma vasopressin, norepinephrine, and renin activity were progressively raised, whereas only the higher level of stimulation increased plasma renin activity, norepinephrine, and vasopressin in hypertensive subjects. Propranolol induced a significant increase in plasma vasopressin in normal subjects (from 1.3 ± 0.1 to 2.0 ± 0.1 pg/ml; p

Original languageEnglish
Pages (from-to)595-602
Number of pages8
JournalHypertension
Volume10
Issue number6
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Internal Medicine

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    Trimarco, B., De Luca, N., De Simone, A., Volpe, M., Ricciardelli, B., Lembo, G., & Condorelli, M. (1987). Impaired control of vasopressin release in hypertensive subjects with cardiac hypertrophy. Hypertension, 10(6), 595-602.