Abstract
Background: Little is known about the cortical activation changes during clinical relapses in multiple sclerosis (MS). Objective: To assess cross-sectional and longitudinal differences in functional magnetic resonance imaging (fMRI) cortical patterns between the relapsing and stable phases of MS.Methods: We studied 32 patients with relapsing-remitting MS with mild disability: 19 within 48 h of symptom onset of a new relapse (G1) and 13 in the stable phase, relapse-free for at least 6 months (G2). All patients underwent fMRI twice, upon entry (time 1) and 30-50 days later (time 2), during right-hand movement.Results: No between-group differences were observed in age, disability or T2 lesion load. Between-group analysis showed a significant difference in the ipsilateral precentral gyrus (IPG) activation at time 1. Activity differences in the IPG expressed reduced deactivation in G1 compared with G2. Longitudinal changes in brain activity in the IPG were significantly greater in G1 than G2. G1 patients with a slow clinical recovery (n = 8) showed different activity at baseline and greater activity changes over time in the IPG than patients with a fast recovery (n = 11).Conclusion: This study shows that the relapsing phase is associated with reduced brain deactivation in the IPG, which is more marked in patients with a slow clinical recovery. Increased cortical excitability associated with inflammation may determine functional modifications within the ipsilateral motor area.
| Original language | English |
|---|---|
| Pages (from-to) | 1177-1184 |
| Number of pages | 8 |
| Journal | Multiple Sclerosis Journal |
| Volume | 17 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- deactivation
- fMRI
- ipsilateral precentral gyrus
- motor cortex
- multiple sclerosis
- relapse
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Impaired cortical deactivation during hand movement in the relapsing phase of multiple sclerosis : A cross-sectional and longitudinal fMRI study. / Pantano, Patrizia; Bernardi, Silvia; Tinelli, Emanuele; Pontecorvo, Simona; Lenzi, Delia; Raz, Eytan; Tona, Francesca; Gasperini, Claudio; Pozzilli, Carlo.
In: Multiple Sclerosis Journal, Vol. 17, No. 10, 2011, p. 1177-1184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impaired cortical deactivation during hand movement in the relapsing phase of multiple sclerosis
T2 - A cross-sectional and longitudinal fMRI study
AU - Pantano, Patrizia
AU - Bernardi, Silvia
AU - Tinelli, Emanuele
AU - Pontecorvo, Simona
AU - Lenzi, Delia
AU - Raz, Eytan
AU - Tona, Francesca
AU - Gasperini, Claudio
AU - Pozzilli, Carlo
PY - 2011
Y1 - 2011
N2 - Background: Little is known about the cortical activation changes during clinical relapses in multiple sclerosis (MS). Objective: To assess cross-sectional and longitudinal differences in functional magnetic resonance imaging (fMRI) cortical patterns between the relapsing and stable phases of MS.Methods: We studied 32 patients with relapsing-remitting MS with mild disability: 19 within 48 h of symptom onset of a new relapse (G1) and 13 in the stable phase, relapse-free for at least 6 months (G2). All patients underwent fMRI twice, upon entry (time 1) and 30-50 days later (time 2), during right-hand movement.Results: No between-group differences were observed in age, disability or T2 lesion load. Between-group analysis showed a significant difference in the ipsilateral precentral gyrus (IPG) activation at time 1. Activity differences in the IPG expressed reduced deactivation in G1 compared with G2. Longitudinal changes in brain activity in the IPG were significantly greater in G1 than G2. G1 patients with a slow clinical recovery (n = 8) showed different activity at baseline and greater activity changes over time in the IPG than patients with a fast recovery (n = 11).Conclusion: This study shows that the relapsing phase is associated with reduced brain deactivation in the IPG, which is more marked in patients with a slow clinical recovery. Increased cortical excitability associated with inflammation may determine functional modifications within the ipsilateral motor area.
AB - Background: Little is known about the cortical activation changes during clinical relapses in multiple sclerosis (MS). Objective: To assess cross-sectional and longitudinal differences in functional magnetic resonance imaging (fMRI) cortical patterns between the relapsing and stable phases of MS.Methods: We studied 32 patients with relapsing-remitting MS with mild disability: 19 within 48 h of symptom onset of a new relapse (G1) and 13 in the stable phase, relapse-free for at least 6 months (G2). All patients underwent fMRI twice, upon entry (time 1) and 30-50 days later (time 2), during right-hand movement.Results: No between-group differences were observed in age, disability or T2 lesion load. Between-group analysis showed a significant difference in the ipsilateral precentral gyrus (IPG) activation at time 1. Activity differences in the IPG expressed reduced deactivation in G1 compared with G2. Longitudinal changes in brain activity in the IPG were significantly greater in G1 than G2. G1 patients with a slow clinical recovery (n = 8) showed different activity at baseline and greater activity changes over time in the IPG than patients with a fast recovery (n = 11).Conclusion: This study shows that the relapsing phase is associated with reduced brain deactivation in the IPG, which is more marked in patients with a slow clinical recovery. Increased cortical excitability associated with inflammation may determine functional modifications within the ipsilateral motor area.
KW - deactivation
KW - fMRI
KW - ipsilateral precentral gyrus
KW - motor cortex
KW - multiple sclerosis
KW - relapse
UR - http://www.scopus.com/inward/record.url?scp=80053584609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053584609&partnerID=8YFLogxK
U2 - 10.1177/1352458511411757
DO - 10.1177/1352458511411757
M3 - Article
C2 - 21677022
AN - SCOPUS:80053584609
VL - 17
SP - 1177
EP - 1184
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 10
ER -