Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients

Lidia Santarpia, Maria Carmen Pagano, Iolanda Cioffi, Lucia Alfonsi, Rosario Cuomo, Giuseppe Labruna, Lucia Sacchetti, Franco Contaldo, Fabrizio Pasanisi

Research output: Contribution to journalArticle

Abstract

Background: Total gastrectomy (TG) is responsible for symptoms or disturbance of alimentary status (changes in body weight, food intake per meal and frequency of meal per day) which, in turn are responsible for weight loss and malnutrition. The study evaluates the gut hormone responses in totally gastrectomized (TG) patients after a liquid meal test. Methods: Twenty total gastrectomized cancer-free patients (12 M, 8 F, 56.4 ± 10.2 years, BMI 21.4 ± 2.2 kg/m2) and 10 healthy volunteers (4 M, 6 F, 48.0 ± 12.7 years, BMI 26.7 ± 3.0 kg/m2) drank a liquid meal (1.25 kcal/mL) at the rate of 50 mL/5′ min for a maximum of 30 min. Satiety score was assessed and blood sample was taken at different time points. Results: The time response course, particularly for insulin, glucose-like pepetide-1, and cholecystokinin, significantly differed between TG patients and controls. Conclusions: Our results may help to better understand hormone responses triggered by the faster arrival of nutrients in the small bowel and to explain some post-TG symptoms.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume71
Issue number3-4
DOIs
Publication statusPublished - Nov 14 2017

Fingerprint

Meals
Gastrectomy
Hormones
Body Weight Changes
Cholecystokinin
Malnutrition
Weight Loss
Healthy Volunteers
Eating
Insulin
Glucose
Food
Neoplasms

Keywords

  • Entero-hormones
  • Liquid meal test
  • Total gastrectomy
  • Weight change

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Santarpia, L., Pagano, M. C., Cioffi, I., Alfonsi, L., Cuomo, R., Labruna, G., ... Pasanisi, F. (2017). Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients. Annals of Nutrition and Metabolism, 71(3-4), 211-216. https://doi.org/10.1159/000481919

Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients. / Santarpia, Lidia; Pagano, Maria Carmen; Cioffi, Iolanda; Alfonsi, Lucia; Cuomo, Rosario; Labruna, Giuseppe; Sacchetti, Lucia; Contaldo, Franco; Pasanisi, Fabrizio.

In: Annals of Nutrition and Metabolism, Vol. 71, No. 3-4, 14.11.2017, p. 211-216.

Research output: Contribution to journalArticle

Santarpia, L, Pagano, MC, Cioffi, I, Alfonsi, L, Cuomo, R, Labruna, G, Sacchetti, L, Contaldo, F & Pasanisi, F 2017, 'Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients', Annals of Nutrition and Metabolism, vol. 71, no. 3-4, pp. 211-216. https://doi.org/10.1159/000481919
Santarpia, Lidia ; Pagano, Maria Carmen ; Cioffi, Iolanda ; Alfonsi, Lucia ; Cuomo, Rosario ; Labruna, Giuseppe ; Sacchetti, Lucia ; Contaldo, Franco ; Pasanisi, Fabrizio. / Impaired Enterohormone Response Following a Liquid Test Meal in Gastrectomized Patients. In: Annals of Nutrition and Metabolism. 2017 ; Vol. 71, No. 3-4. pp. 211-216.
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