Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

P. Di Bonito, Lucia Pacifico, C. Chiesa, G. Valerio, E. Miraglia Del Giudice, C. Maffeis, A. Morandi, C. Invitti, M. R. Licenziati, Sandro Loche, G. Tornese, F. Franco, M. Manco, Marco Giorgio Baroni, "CARdiometabolic risk factors in overweight, obese children in ITALY" (CARITALY) Study Group

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.
Original languageUndefined/Unknown
Pages (from-to)409-416
Number of pages8
JournalJournal of Endocrinological Investigation
Volume40
Issue number4
DOIs
Publication statusPublished - Nov 16 2016

Keywords

  • Cardiometabolic risk factors
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • Pediatric obesity
  • Prediabetes

Cite this

Di Bonito, P., Pacifico, L., Chiesa, C., Valerio, G., Giudice, E. M. D., Maffeis, C., ... Group, O. C. I. ITALY. CARITALY. S. (2016). Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. Journal of Endocrinological Investigation, 40(4), 409-416. https://doi.org/10.1007/s40618-016-0576-8 [doi]

Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. / Di Bonito, P.; Pacifico, Lucia; Chiesa, C.; Valerio, G.; Giudice, E. Miraglia Del; Maffeis, C.; Morandi, A.; Invitti, C.; Licenziati, M. R.; Loche, Sandro; Tornese, G.; Franco, F.; Manco, M.; Baroni, Marco Giorgio; overweight, "CARdiometabolic risk factors in; Group, obese children in ITALY" (CARITALY) Study.

In: Journal of Endocrinological Investigation, Vol. 40, No. 4, 16.11.2016, p. 409-416.

Research output: Contribution to journalArticle

Di Bonito, P, Pacifico, L, Chiesa, C, Valerio, G, Giudice, EMD, Maffeis, C, Morandi, A, Invitti, C, Licenziati, MR, Loche, S, Tornese, G, Franco, F, Manco, M, Baroni, MG, overweight, CARRFI & Group, OCIITALYCARITALYS 2016, 'Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity', Journal of Endocrinological Investigation, vol. 40, no. 4, pp. 409-416. https://doi.org/10.1007/s40618-016-0576-8 [doi]
Di Bonito, P. ; Pacifico, Lucia ; Chiesa, C. ; Valerio, G. ; Giudice, E. Miraglia Del ; Maffeis, C. ; Morandi, A. ; Invitti, C. ; Licenziati, M. R. ; Loche, Sandro ; Tornese, G. ; Franco, F. ; Manco, M. ; Baroni, Marco Giorgio ; overweight, "CARdiometabolic risk factors in ; Group, obese children in ITALY" (CARITALY) Study. / Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. In: Journal of Endocrinological Investigation. 2016 ; Vol. 40, No. 4. pp. 409-416.
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abstract = "OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3{\%}) and IGT (4.6 vs. 5.0{\%}) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.",
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TY - JOUR

T1 - Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

AU - Di Bonito, P.

AU - Pacifico, Lucia

AU - Chiesa, C.

AU - Valerio, G.

AU - Giudice, E. Miraglia Del

AU - Maffeis, C.

AU - Morandi, A.

AU - Invitti, C.

AU - Licenziati, M. R.

AU - Loche, Sandro

AU - Tornese, G.

AU - Franco, F.

AU - Manco, M.

AU - Baroni, Marco Giorgio

AU - overweight, "CARdiometabolic risk factors in

AU - Group, obese children in ITALY" (CARITALY) Study

N1 - LR: 20170322; JID: 7806594; OTO: NOTNLM; 2016/10/05 [received]; 2016/11/03 [accepted]; ppublish

PY - 2016/11/16

Y1 - 2016/11/16

N2 - OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.

AB - OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.

KW - Cardiometabolic risk factors

KW - Impaired fasting glucose

KW - Impaired glucose tolerance

KW - Pediatric obesity

KW - Prediabetes

U2 - 10.1007/s40618-016-0576-8 [doi]

DO - 10.1007/s40618-016-0576-8 [doi]

M3 - Articolo

VL - 40

SP - 409

EP - 416

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

IS - 4

ER -